Results 51 to 60 of about 39,672 (240)

Impact of Organizational Culture on Employee Engagement and Employee Performance: A Stimuli-Organism-Response Approach

Wacana: Jurnal Sosial dan Humaniora, 2021
This study examines the impact of organizational culture on employee engagement and employee performance. Within the organization, organizational culture plays an important role in building employee engagement, and ultimately in Employee Performance. The
Halid Hasan, Endang Siti Astuti, Tri Wulida Afrianty, Mohammad Iqbal   +3 more
doaj  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

KEPRIBADIAN KARYAWAN DAN BUDAYA ORGANISASI: FAKTOR DETERMINAN KETERIKATAN KARYAWAN (EMPLOYEE ENGAGEMENT)

Jurnal Manajemen, 2017
Penelitian dilatarbelakangi oleh hasil penjualan yang menurun dan tidak memenuhi target, denda keterlambatan penyelesaian proyek yang tinggi, dan kerugian yang dialami oleh PT X, salah satu perusahaan yang bergerak pada industri telekomunikasi di Jawa ...
Rian Nurjanah, Rofi Rofaida, Suryana Suryana   +2 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The influence of transformational and transactional leadership on employee retention: mediating role of employee engagement [PDF]

Management Matters
Purpose – The study aims to investigate the relationship between transformational, transactional leadership and employee retention with the mediating effect of employee engagement.
Mohammad Ali, Xiongying Niu, Mohammad Rabiul Basher Rubel   +2 more
doaj   +1 more source

Relationships and Mediating Effects of Employee Engagement: An Empirical Study of Managerial Employees of Sri Lankan Listed Companies

SAGE Open, 2020
This study is a systematic and scientific attempt to fill five identified research gaps in the existing literature with regard to employee engagement through the use of empirical evidence from Sri Lankan listed companies.
Yasangi Anuradha Iddagoda, Henarath H. D. N. P. Opatha   +1 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Improving Aon Hewitt Indonesia Employee Engagement Survey Product Using Engagement-Job Burnout Model

Jurnal Manajemen Indonesia, 2019
Aon Hewitt Indonesia (AHI) as global HR consulting firm serves in Indonesia providing employee engagement survey for their clients. The survey is to assess the company’s employee engagement condition and with key deliverables solutions to improve the
Adyansyah Patonangi, Aurik Gustomo
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source