Results 51 to 60 of about 39,878 (240)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Impact of Organizational Culture on Employee Engagement and Employee Performance: A Stimuli-Organism-Response Approach

Wacana: Jurnal Sosial dan Humaniora, 2021
This study examines the impact of organizational culture on employee engagement and employee performance. Within the organization, organizational culture plays an important role in building employee engagement, and ultimately in Employee Performance. The
Halid Hasan, Endang Siti Astuti, Tri Wulida Afrianty, Mohammad Iqbal   +3 more
doaj  

Relationships and Mediating Effects of Employee Engagement: An Empirical Study of Managerial Employees of Sri Lankan Listed Companies

SAGE Open, 2020
This study is a systematic and scientific attempt to fill five identified research gaps in the existing literature with regard to employee engagement through the use of empirical evidence from Sri Lankan listed companies.
Yasangi Anuradha Iddagoda, Henarath H. D. N. P. Opatha   +1 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

KEPRIBADIAN KARYAWAN DAN BUDAYA ORGANISASI: FAKTOR DETERMINAN KETERIKATAN KARYAWAN (EMPLOYEE ENGAGEMENT)

Jurnal Manajemen, 2017
Penelitian dilatarbelakangi oleh hasil penjualan yang menurun dan tidak memenuhi target, denda keterlambatan penyelesaian proyek yang tinggi, dan kerugian yang dialami oleh PT X, salah satu perusahaan yang bergerak pada industri telekomunikasi di Jawa ...
Rian Nurjanah, Rofi Rofaida, Suryana Suryana   +2 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

The influence of transformational and transactional leadership on employee retention: mediating role of employee engagement [PDF]

Management Matters
Purpose – The study aims to investigate the relationship between transformational, transactional leadership and employee retention with the mediating effect of employee engagement.
Mohammad Ali, Xiongying Niu, Mohammad Rabiul Basher Rubel   +2 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Improving Aon Hewitt Indonesia Employee Engagement Survey Product Using Engagement-Job Burnout Model

Jurnal Manajemen Indonesia, 2019
Aon Hewitt Indonesia (AHI) as global HR consulting firm serves in Indonesia providing employee engagement survey for their clients. The survey is to assess the company’s employee engagement condition and with key deliverables solutions to improve the
Adyansyah Patonangi, Aurik Gustomo
doaj   +1 more source