Results 101 to 110 of about 9,658 (260)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

AI-POWERED EMPLOYEE EXPERIENCE AS A STRATEGIC ENABLER OF SUSTAINABLE HUMAN CAPITAL MANAGEMENT

Соціально-економічні відносини в цифровому суспільстві
The growing integration of artificial intelligence (AI) into human resource management has significantly transformed the ways organizations manage employee experience and develop human capital capabilities.
Yuliia Lazarenko
doaj   +1 more source

Development of Employee Integration: Share Ownership Perspective

In recent decades the world has experienced changes in business paradigm – from manufacturing oriented to human oriented. Nevertheless many companies still operate the old way.
Šumilo, Ērika, Baumane-Ozoliņa, Ilona, Dovladbekova, Inna, Berķe-Berga, Anželika   +3 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Beyond Aesthetics. The Strategic Role of Art and Design in Renewing Italian Corporate Spaces [PDF]

Pad
This article explores the emerging role of art and design in Italian workplaces, highlighting how their integration redefines professional spaces, enhances employee well-being, and boosts company performance.
Marzia Tomasin
doaj  

Will Employee–AI Collaboration Enhance Employees’ Proactive Behavior? A Study Based on the Conservation of Resources Theory

Behavioral Sciences
This study explores how employee–AI collaboration can promote employees’ proactive behavior by reducing their workload, and examines the mediating role of workload and the moderating effect of AI literacy.
Chenxi Sun, Xinan Zhao, Baorong Guo, Ningning Chen   +3 more
doaj   +1 more source

Social Integration and Employees with a Disability: Their View

Disability Studies Quarterly, 2004
Varied research has addressed social integration at the workplace of persons with disabilities. Goffman (1963) and others propose that disability interferes with ordinary social interactions, creating a class of stigmatized interactions. Whether perceived or experienced, stigmatization leads to negative outcomes for the recipient of stigma.
openaire   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Employee Performance Analysis with Digital Business Transformation and Organizational Culture as Leveraging Factors

Almana: Jurnal Manajemen dan Bisnis
Digital business transformation, driven by technologies such as big data analytics, machine learning, and artificial intelligence, plays a crucial role in enhancing organizational competitiveness.
Sheila Pratiwi Nasution, Stefanus M.S. Sadana   +1 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source