Results 111 to 120 of about 1,048,262 (316)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
The Recognition and Reward of Employee Performance [PDF]
, 1989 [Excerpt] This paper examines when and to what extent an individual\u27s relative wage depends on his/her productivity relative to others doing the same job.
Bishop, John H.
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
International Journal of Business Science and Applied Management, 2023 The purpose of this study is to explore a moderated mediation model of ambidextrous leadership and employee ambidexterity in the relationship between a high-performance work system and employee work performance.
Ijigu, A.W., Alemu, A.E., & Kuhil, A.M.
doaj
Digital Leadership's Influence on Individual Creativity and Employee Performance: A View through the Generational Lens. [PDF]
Behav Sci (Basel), 2023 Öngel V +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Impact of Toxic Leadership on Employee Performance. [PDF]
Health Psychol Res, 2022 Wolor CW +4 more
europepmc +1 more source
PENGARUH MOTIVASI KERJA TERHADAP KINERJA KARYAWAN [PDF]
The labor conditions in Indonesia are confronted with issues of unemployment, low productivity, and a significant number of workers employed in the informal sector. Low productivity impacts the level of employee performance. Performance becomes a crucial
Hasanah, Ambar Dyna
core
Pengaruh Total Quality Management(TQM) Terhadap Kinerja Karyawan Akuntansi Dengan Reward Sebagai Variabel Moderasi [PDF]
, 2013 This study aims to Determine Whether a variable reward may moderate the relationship between total quality management with employee performance accounting in commercial banking companies in the city of Palembang. The sample in this study is accounting
., Fredy
core