Results 71 to 80 of about 167,070 (236)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

The Decision Support System Design Of Employee Performance Appraisal Using Analytical Hierarchi Process (AHP) Method

open access: yes, 2012
A performance appraisal is important for every employee and it is also useful for companies to assign the next policy action. In RS Roemani, the performance appraisal process is used for the promotion, the performance evaluation, the hajj subsidy, the ...
Rochmat , Taufiq
core  

Pengaruh Penilaian Kerja, Kompensasi Terhadap Kinerja Karyawan Melalui Motivasi Pada PT Bank Negara Indonesia (Persero) Tbk Cabang Undip Semarang [PDF]

open access: yes, 2015
Email: christinegultom23@gmail.comAbstract: Human resources has a very important role in the company, because humanresources is an important key in empowering other resources. The success of a company inachieving its objectives can\u27t be separated from
Gultom, C. N. (Christine)   +2 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Competitive Strategy, Performance Appraisal and Firm Results

open access: yes, 2016
In this study, we address the relationship between performance appraisal and competitive strategy, as well as the impact of this relationship on firm performance.
Bayo-Moriones, Alberto   +2 more
core  

Performance Criteria And Utilization Of Performance Appraisal In The Royal Malaysian Police Force [PDF]

open access: yes, 1994
Performance appraisal has become increasingly important tool for organization to use in managing and improving employee' s performance.However,little empirical result has been conducted to determine( a ) the extent to which performance criteria were ...
Lee, Yen Thing
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Employee Performance Appraisal in Business [PDF]

open access: yesProceedings of the The First International Conference On Islamic Development Studies 2019, ICIDS 2019, 10 September 2019, Bandar Lampung, Indonesia, 2019
Mohammad Ghozali   +3 more
openaire   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

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