Results 101 to 110 of about 292,860 (358)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

State-owned enterprises: Developing and validating a model of employee retention

open access: yesSA Journal of Industrial Psychology
Orientation: The high turnover rate of essential core skills in South African state-owned enterprises (SOEs) is a significant issue, raising serious concerns about employee retention.
Christinah H. Maphanga   +1 more
doaj   +1 more source

Investing in Entry-Level Talent [PDF]

open access: yes, 2017
Even in today's competitive economic environment, there is much that companies can do to reduce entry-level turnover costs, increase employee engagement and retention, and create a talent pipeline for the future. Many companies pursue basic strategies to
Fay Hanleybrown, Kimbery Gilsdorf
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Molecular cancer prevention: Intercepting disease

open access: yesMolecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco   +2 more
wiley   +1 more source

A Work–Life Balance, Career Development, Leadership, and Engagement as Predictors of Employee Retention: The Moderating Role of Perceived Organizational Support and Organizational Commitment.

open access: yesMarket Forces
The need to retain employees has become a strategic priority for companies due to high turnover and labor market competition. Grounded in the Social Exchange Theory, this study is one of the few empirical studies that examined the connections among work ...
Khurram Adeel Shaikh, Muhammad Khalique
doaj   +1 more source

“You’re Nobody ‘til Somebody Loves You”: The Use of Job Search for Bargaining Leverage [PDF]

open access: yes, 2002
The purpose of this research is to investigate a previously overlooked yet important objective for an employee engaging in job search – seeking alternative employment to obtain leverage against the current employer. We focus specifically on how employees
Boswell, Wendy R.   +2 more
core   +2 more sources

The Effect of Supportive Work Environment on Employee Retention at Malaysia Information, Communication, and Technology (ICT) Industry [PDF]

open access: diamond, 2019
Nurul Ezaili Alias   +4 more
openalex   +1 more source

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