Results 81 to 90 of about 2,712,905 (331)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Effects of executive-level leader's transformational leadership on talent retention in post merger and acquisition in China [PDF]

, 2014
Talent retention, which can be defined as organizational practices aiming at maintaining the continued employment of high potential and high-performing incumbents to fill the key positions that have the potential to have an impact on the competitive ...
Zhang, J
core  

Retention Strategies for Technical Talents in the Technological Sector

Journal of Human Resource Management
Purpose – Despite the growing recognition of human capital as a key driver of organizational success, many technological companies in Lagos State face persistent challenges in retaining skilled employees.
Abdulmaleek Olawale ABDULAZEEZ, Uthman Opeyemi ADIGUN, Lateef Damilare OLUSESI   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Employee Retention: Effect of Compensation, Work Stress, and Job Satisfaction. A Case Study in an Edible Birds Nest Company [PDF]

This study was conducted to measure compensation factors and job stress on job satisfaction that may affect employee retention rates. A case study was conducted on a swiftlet company by conducting a questionnaire-based survey to collect data and ...
Agustin, Karina, Sutapa, I Nyoman, WONGSO, BILLY INDRAWAN   +2 more
core   +1 more source

ANALYSIS ON EQUITY SHARE BEING OFFERED TO ELIGIBLE EMPLOYEES FOR EMPLOYEE RETENTION IN LARGE CAP STOCKS

ICTACT Journal on Management Studies
Equity shares are increasingly utilized by companies to retain talent and align employee interests with organizational goals. Large-cap stocks, due to their stability and growth potential, offer a unique context for evaluating this retention strategy ...
Anil Kumar Yadav
doaj   +1 more source

Strategies for Reducing Employee Turnover in Small- and Medium-Sized Enterprises

Westcliff International Journal of Applied Research, 2020
Employee turnover leads to increased operational costs and workloads and affects sales performance. Reducing employee turnover is essential for managers of small and medium sized enterprises to minimize costs and increase sales performance.
Kate S Andrews, Tijani Mohammed
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source