Results 81 to 90 of about 22,872 (261)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Productive Employee Training and Its Impact on Retention

open access: yesNepal Journal of Multidisciplinary Research
Background: The present research examines the financial aspects of efficacious employee training and its influence on employee retention in corporate environments.
Ajaya Kumar Khadka , Srijana Khadka
doaj   +1 more source

Employee Retention and Change Management During Times of Uncertainty. [PDF]

open access: yesFront Psychol, 2022
Ekhsan M   +3 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

A Work–Life Balance, Career Development, Leadership, and Engagement as Predictors of Employee Retention: The Moderating Role of Perceived Organizational Support and Organizational Commitment.

open access: yesMarket Forces
The need to retain employees has become a strategic priority for companies due to high turnover and labor market competition. Grounded in the Social Exchange Theory, this study is one of the few empirical studies that examined the connections among work ...
Khurram Adeel Shaikh, Muhammad Khalique
doaj   +1 more source

A Threat of Customer Incivility and Job Stress to Hotel Employee Retention: Do Supervisor and Co-Worker Supports Reduce Turnover Rates? [PDF]

open access: yesInt J Environ Res Public Health, 2021
Chung H   +6 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Employee Retention Factor at IT Startup Company: Job Satisfaction as Mediating Variable

open access: yesMedia Ekonomi dan Manajemen
This study analyzes factors that have implications for employee retention in IT-Startup companies. This study aims to explain factors that contribute to employee retention with job satisfaction as a mediating variable.
Ahmad Azmy, Antoni Ludfi Arifin
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

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