Results 61 to 70 of about 33,430 (260)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Employee Voice Expression Mechanisms and Organizational Recognition: Strategies to Improve Organizational Citizenship Behavior and Increase Retention

, 2023
The importance and impact of employee voice expression has been studied extensively in the literature within multiple contexts. Many organizations believe creating a culture and building in processes where employees feel safe to express their voice lead ...
Hilliard, Robyn.
core   +1 more source

Employee Perceptions of Their Company’s Employee Retention Strategy: A Case Study of a Manufacturing Company

Administrative Sciences
The global and national skills shortages, shifting employee work attitudes post-COVID pandemic, and the presence of a multigenerational workforce with diverse needs and preferences have sparked interest in employee retention.
Zikhona Prudence Ndlela, Cebile Tebele, Samuel Siwela   +2 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Recruitment and retention issues in rural labour markets [PDF]

, 2011
This paper aims to provide insights into the recruitment and retention issues faced by employers in rural areas. To this end, information gathered through interviews with employers and labour market intermediaries in the predominantly rural county of ...
De Hoyos, Maria, Green, Anne E., Maria de Hoyos, Anne Green   +3 more
core   +1 more source

The Impact of Internal Employer Branding on Employee Engagement and Retention

Organizacijų Vadyba: Sisteminiai Tyrimai
The goal of this research is to identify the impact of IEB on employee engagement and retention in IT companies. The quantitative research involved 203 IT professionals.
Alonderienė Raimonda, Urbelė Julija
doaj   +1 more source

The Impact of Human Resource Management Practices on Employee Satisfaction: Hospitaly Contex

Jurnal Aplikasi Bisnis dan Manajemen
Background: Human resource management (HRM) practices are essential tools employed by hotel management to achieve organizational objectives. Purpose: The aim of this study was to investigate how HRM practices impact job satisfaction and employee ...
Paniran Paniran, Juliansyah Noor, Soleh Soleh, Mukhtar Wahyudi   +3 more
doaj   +1 more source

Retention HR Practices and Employee Retention in the Banking Sector of Pakistan

Journal of Accounting and Finance in Emerging Economies, 2020
Purpose: Human Resource is one of the most valuable resources in any organization and its contribution is massive everywhere in the world.  Human Resources (HR) practices can be helpful to retain valued employees.
Muhammad Aleem, Zulfiqar Ahmad Bowra
doaj   +1 more source