Results 71 to 80 of about 33,430 (260)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Employee perceptions of workforce retention strategies in a health system

, 2011
Retaining a skilled workforce and decreasing unwanted employee turnover is an economic and service delivery necessity for organisations. Key to operational and service delivery excellence is high employee retention. Many studies have investigated the job
Belbin, Cheryl
core  

Sustainable Workforce: The Role of Employee Engagement on Perceived Organizational Support to Employee Retention

Philanthropy: Journal of Psychology
. Retaining talented employees in the competitive pharmaceutical industry becomes crucial for company success. This study explores employee engagement's role as a mediator in the influence of perceived organizational support on pharmaceutical employees ...
Zetiara Nurul Sabila, Gumgum Gumelar, Zarina Akbar   +2 more
doaj   +1 more source

Factors affecting employee retention: An empirical study in Nepalese commercial banks [PDF]

Banks and Bank Systems
This paper aims to identify the factors affecting employee retention in Nepalese financial institutions, especially commercial banks. Through a questionnaire, the primary data were collected from 400 respondents. The study is based on a dichotomous and 5-
Rabin Subedi, Amiya Bhaumik, Surendra Neupane   +2 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Career development programs and employee retention: Insights from the Ministry of Works in Tanzania

This study examined the relationship between career development initiatives and employee retention at the Ministry of Works in Tanzania. The study was guided by equity theory, which was founded on the assumption that employees tend to remain with their ...
Chacha Magasi, Hindu Augossy, Richard Msacky   +2 more
core   +1 more source

The Influence of Compensation and Career Development on Employee Retention with Job Satisfaction as Mediation at CV Znepa Karya Mandiri Bekasi

Indonesian Interdisciplinary Journal of Sharia Economics
Retaining competent employees is crucial for a company's success, defined as efforts to prevent the departure of talented and potential employees. Employee retention serves as a vital indicator of organizational effectiveness, alongside key factors such
Dea Nursifa, Fitri Rezeki, Anna Wulandari   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Employee retention and the moderating role of psychological ownership in retail

, 2022
Retailing is one of the critical stages in supply chain operations, in which human resources and employee retention play a decisive role as in any organization.
Nguyen, Thi Ngoc Diep, Nguyen, Chi Doan Hanh, Homolka, Lubor, Hoang, Duc Sinh   +3 more
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source