Results 51 to 60 of about 19,452 (300)

The effect of psychological capital level of employees on workplace stress and employee turnover intention.

, 2018
There have been ongoing debates on ways to manage occupational stress. One of the most important debates is on how to increase employees’ resistance level against stress.
M. Çelik
semanticscholar   +1 more source

Burnout, work–life balance, and turnover intention: The mediating role of engagement

Review of Management, Accounting, and Business Studies
In an era of rapid business change and intensifying global competition, effective human resource management is critical for sustaining organizational performance.
Nazli Fajriawan, Ni Putu Ayu Muspita Dewi   +1 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Factors of Work Satisfaction and Their Influence on Employee Turnover in Bangkok, Thailand

International Journal of Technology, 2018
A high rate of employee turnover is an issue that organizations face on a regular basis. This issue has affected organizations by impacting on job performance and lowering productivity, profitability, and customer satisfaction.
Suprasith Jarupathirun, Michela De Gennaro   +1 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

A paradox: employee development and intention to turnover [PDF]

Journal of Economics, Business, & Accountancy Ventura, 2019
Employee development program aims to strenghten talents and as a optimal retention program. Development program which is not followed by interesting career development opportunities can be occured turn over intentions. Employability Paradoxs is an employee development program which brings   increasing turn over intentions risk.
Praptini Yulianti, Cecilia Margaretha
openaire   +3 more sources

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

ANALYSIS OF THE EFFECT OF PERSONALITY ON TURNOVER INTENTION BASED ON EMOTIONAL DATA: A CASE STUDY OF JOB BURNOUT AND EMPLOYEE ENGAGEMENT AT PT. SEJAHTERA KURIR EXPRESS CIREBON

Indonesian Interdisciplinary Journal of Sharia Economics
This study aims to analyze the effect of personality on turnover intention, with job burnout and employee engagement serving as mediating variables at PT Sejahtera Kurir Express Cirebon.
Suci Fitaloka Putri, Kartono Kartono
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source