Results 91 to 100 of about 1,588,043 (289)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Does the Self-employment Policy Reduce Unemployment and Increase Employment? Empirical Evidence from the Czech Regions

Central European Journal of Public Policy, 2017
Empirical evidence related to the effectivity and outcomes of the self-employment programmes in the Central and Eastern Europe is still very rare, despite the important role of entrepreneurship in the economic development of post-communist economies. The
Dvouletý Ondřej
doaj   +1 more source

Employment and breast cancer: A meta-ethnography [PDF]

, 2011
This article is available open access through the publisher’s website at the link below. Copyright @ 2011 Blackwell Publishing Ltd.The purpose of this synthesis is to examine the qualitative evidence on the lived experience of breast cancer survivors in ...
Banning, M
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Supported employment coaches’ difficulties and facilitators with clients diagnosed with personality versus other disorders: A qualitative study

Heliyon
Aim: People with severe mental illnesses (SMI) face different occupational challenges than those diagnosed with personality disorders (PD). Supported employment (SE) has been validated for SMI patients but its effectiveness for individuals with PD ...
Noëllie Dunand, Marine Seydoux, Melissa Teixeira Magalhaes, Charles Bonsack, Philippe Golay, Danièle Spagnoli, Valentino Pomini   +6 more
doaj   +1 more source

Using Instructional Design, Analyze, Design, Develop, Implement, and Evaluate, to Develop e-Learning Modules to Disseminate Supported Employment for Community Behavioral Health Treatment Programs in New York State

Frontiers in Public Health, 2018
BackgroundImplementation science lacks a systematic approach to the development of learning strategies for online training in evidence-based practices (EBPs) that takes the context of real-world practice into account.
Sapana R. Patel, Sapana R. Patel, Paul J. Margolies, Paul J. Margolies, Nancy H. Covell, Nancy H. Covell, Cristine Lipscomb, Lisa B. Dixon, Lisa B. Dixon   +8 more
doaj   +1 more source

Public employment and the double role of bureaucrats [PDF]

Bureaucrats in the government sector have a double role since they are both suppliers and demanders of public employment; they are publicly employed (supply labor) and they have an important say in deciding the size of the municipal employment (demand ...
Dahlberg, Matz, Mörk, Eva
core  

Disability Employment Policy [PDF]

, 2004
This paper is the first in a series aimed at analyzing disability employment policy and developing recommendations for policy reform in middle income countries. As the first paper in this series, this study provides a general overview of the relationship
Mont, Daniel
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The Swedish Youth Labor Market in Boom and Depression [PDF]

This paper is concerned with the labor market experience of Swedish youths during the 1980s and the 1990s. The first objective is to portray early economic attainment among young Swedes. The second objective of the paper is to examine the impact of labor
Edin, Per-Anders, Forslund, Anders, Holmlund, Bertil   +2 more
core