Results 121 to 130 of about 314,024 (302)
A qualitative study of the IPS employment specialist role in the context of Nav employment in Norway
BMC PsychiatryBackground Employment is recognised as a fundamental human right. Still, many people experiencing severe mental illness are outside the workforce. Appropriate employment has several benefits for mental health and is central to recovery and citizenship ...
Cathrine Moe +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Supported Employement: Recommendations for successful implementation in South Africa
South African Journal of Occupational Therapy, 2011 Introduction: This article reports on the findings of a descriptive qualitative study in which supported employment (SE), as a potential strategy to facilitate the employment of persons with disability in the open labour market in South Africa, was ...
Lana van Niekerk +6 more
doaj
, 2015 Title from PDF caption (viewed on April 17, 2019)."Xiao ji tuan zhi chi jiu ye ji hui zhi ji tuan(shao yu 8 ren)zuo wei xing dong xiao zu huo gong zuo zu kai zhan de fu wu he huo dong."This archived document is maintained by the State Library of Oregon ...
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Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Would you train me with my mental illness? Evidence from a discrete choice experiment [PDF]
The low employment among people with disabilities in general, and mental disorders in particular, generates high costs to the society. This raises the need to develop effective vocational rehabilitation methods.
Deuchert, Eva +2 more
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