Results 41 to 50 of about 34,637 (221)
Scientific Reports, 2021 Activity of the Epithelial Na+ Channel (ENaC) in the distal nephron fine-tunes renal sodium excretion. Appropriate sodium excretion is a key factor in the regulation of blood pressure.
Tarek Mohamed Abd El-Aziz +7 more
doaj +1 more source
Comparing policy gradient and value function based reinforcement learning methods in simulated electrical power trade [PDF]
, 2012 In electrical power engineering, reinforcement learning algorithms can be used to model the strategies of electricity market participants. However, traditional value function based reinforcement learning algorithms suffer from convergence issues when ...
Burt, Graeme +3 more
core +1 more source
Cellular Physiology and Biochemistry, 2018 Background/Aims: The epithelial sodium channel (ENaC) in cortical collecting duct (CCD) principal cells plays a critical role in regulating systemic blood pressure.
Yu-Jia Zhai +11 more
doaj +1 more source
The relationship between P2X4 and P2X7: a physiologically important interaction? [PDF]
, 2013 Purinergic signaling within the kidney is becoming an important focus in the study of renal health and disease. The effectors of ATP signaling, the P2Y and P2X receptors, are expressed to varying extents in and along the nephron.
Birch, Rebecca E +3 more
core +3 more sources
Toxins, 2023 Cancer progression is characterized by microenvironmental acidification. Tumor cells adapt to low environmental pH by activating acid-sensing trimeric ion channels of the DEG/ENaC family.
Ekaterina N. Lyukmanova +8 more
doaj +1 more source
Cav3.2 calcium channel interactions with the epithelial sodium channel ENaC
Molecular Brain, 2019 This study describes the functional interaction between Cav3.2 calcium channels and the Epithelial Sodium Channel (ENaC). β-ENaC subunits showed overlapping expression with endogenous Cav3.2 calcium channels in the thalamus and hypothalamus as detected ...
Agustin Garcia-Caballero +7 more
doaj +1 more source
Interaction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation. [PDF]
PLoS ONE, 2010 The epithelial sodium channel (ENaC) is an integral component of the pathway for Na(+) absorption in epithelial cells. The ubiquitin ligases Nedd4 and Nedd4-2 bind to ENaC and decrease its activity.
Dominik Wiemuth +6 more
doaj +1 more source
Syntaxin 1A Regulates ENaC Channel Activity [PDF]
Journal of Biological Chemistry, 2004 Na(+) entry across the apical membranes of many absorptive epithelia is determined by the number (N) and open probability (P(o)) of epithelial sodium channels (ENaC). Previous results showed that the H3 domain of syntaxin-1A (S1A) binds to ENaC to reduce N, supporting a role for S1A in the regulation of ENaC trafficking.
Steven B, Condliffe +2 more
openaire +2 more sources
Clinical Medicine Insights: Cardiology, 2010 The epithelial sodium channel (ENaC) is critical in maintaining sodium balance across aldosterone-responsive epithelia. ENaC is a combined channel formed of three subunits (αβγ) with α ENaC subunit being the most critical for channel functionality.
Marlene F. Shehata
doaj +1 more source
PIP2 Interacts Electrostatically with MARCKS-like Protein-1 and ENaC in Renal Epithelial Cells
Biology, 2022 We examined the interaction of a membrane-associated protein, MARCKS-like Protein-1 (MLP-1), and an ion channel, Epithelial Sodium Channel (ENaC), with the anionic lipid, phosphatidylinositol 4, 5-bisphosphate (PIP2).
Qiang Yue +6 more
doaj +1 more source