Results 81 to 90 of about 34,637 (221)
Journal of Fish Biology, EarlyView.Abstract The branchial epithelium of Potamotrygon—a member of the only strictly freshwater elasmobranch family Potamotrygonidae—was observed via immunohistochemistry, and two distinct forms of ionocytes were identified. The acid (A‐type) and base (B‐type) secreting cells with respective basolateral–apical localizations of Na+/K+‐ATPase–Na+/H+ exchanger
M. W. Rossi +3 more
wiley +1 more source
Acetylation Modulates ENaC Degradation
The FASEB Journal, 2013 The epithelial Na + channel (ENaC) forms a pathway for Na + absorption across epithelia in the renal collecting duct. Dysregulation of ENaC results in defective blood pressure regulation (e.g. Liddle's syndrome and pseudohypoaldosteronism type I).
Phillip L Butler, Peter M Snyder
openaire +1 more source
Versatility of NaCl transport mechanisms in the cortical collecting duct [PDF]
, 2017 Versatility of NaCl transport mechanisms in the cortical collecting duct. Am J Physiol Renal Physiol 313: F1254 –F1263, 2017. First published September 6, 2017; doi:10.1152/ajprenal.00369.2017.—The cortical collecting duct (CCD) forms part of the ...
Crambert, Gilles, Edwards, Aurelie
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Veterinary Clinical Pathology, EarlyView.Abstract Urinary extracellular vesicles (UEVs) are membranous particles that carry renal tubular transporter proteins. Here, we evaluate whether selected renal tubular transporter proteins can be detected in UEVs isolated from small volume (1–5 mL) canine urine samples of healthy dogs and canine patients with elevated circulating parathyroid hormone ...
L. J. McGravey +2 more
wiley +1 more source
Dissecting the genetic components of a quantitative trait locus for blood pressure and renal pathology on rat chromosome 3 [PDF]
, 2017 Background: We have previously confirmed the importance of rat chromosome 3 (RNO3) genetic loci on blood pressure elevation, pulse pressure (PP) variability and renal pathology during salt challenge in the stroke-prone spontaneously hypertensive (SHRSP ...
Beattie, Wendy +8 more
core +2 more sources
Experimental Physiology, EarlyView.Abstract The antihypertensive mechanism of sodium–glucose cotransporter 2 (SGLT2) inhibitors has been traditionally attributed to osmotic diuresis. However, emerging evidence reveals multifaceted mechanisms beyond diuresis, including regulation of the renin–angiotensin–aldosterone system, sympathetic nervous system suppression, ion homeostasis ...
Chunxiang Xu +5 more
wiley +1 more source
Clinical Medicine Insights: Cardiology, 2010 The epithelial sodium channel (ENaC) is critical in maintaining sodium balance across aldosterone-responsive epithelia. ENaC is a combined channel formed of three subunits (αβγ) with α ENaC subunit being the most critical for channel functionality.
Marlene F. Shehata
doaj
Epithelial Na+ Channel: Reciprocal Control by COMMD10 and Nedd4-2
Frontiers in Physiology, 2018 Optimal function of the epithelial sodium channel (ENaC) in the distal nephron is key to the kidney’s long-term control of salt homeostasis and blood pressure.
Adam W. Ware +4 more
doaj +1 more source
SPX-101 is stable in and retains function after exposure to cystic fibrosis sputum [PDF]
, 2019 Background: In healthy lungs, epithelial sodium channel (ENaC) is regulated by short, palate, lung, and nasal clone 1 (SPLUNC1). In cystic fibrosis (CF), ENaC is hyperactivated in part due to a loss of SPLUNC1 function.
Scott, David W. +3 more
core +1 more source
Ouabain‐induced hypertension in rats: Mechanisms, variability and translational implications
Experimental Physiology, EarlyView.Abstract Ouabain‐induced hypertension is a multifactorial and condition‐dependent phenomenon involving coordinated actions across vascular, renal and central nervous system pathways. At the vascular level, ouabain inhibits Na⁺/K⁺‐ATPase, particularly the α2‐isoform, leading to elevated intracellular Ca2⁺, enhanced vasoconstriction and structural ...
Priscilla Rodrigues O. Feijó +1 more
wiley +1 more source