Results 71 to 80 of about 75,325 (204)

Thiamine Diphosphate‐Dependent Biocatalysis in the 21st Century

Chemistry – A European Journal, EarlyView.
This account summarizes the major discoveries and recent advances, highlighting the biocatalytic abilities, mechanistic studies, and feature‐based classification that are shaping emerging perspectives on thiamine diphosphate (ThDP)‐dependent catalysis.
Lucrezia Lanza, Daniela Bjarnesen, Michael Müller   +2 more
wiley   +1 more source

Molecular modeling of MOF membranes for gas separations

, 2017
Metal organic frameworks (MOFs) have received significant attention as membrane materials in the last decade. MOFs typically have high porosities, tunable pore sizes, large surface areas, reasonable thermal and mechanical stabilities.
Keskin, S., Fındıkçı, İlknur Eruçar   +1 more
core   +1 more source

The Effect of Dicloxacillin Administration on Pharmacokinetics of Narrow Therapeutic Window Drugs: Phenytoin and Warfarin

Clinical Pharmacology &Therapeutics, EarlyView.
Dicloxacillin is a penicillinase‐resistant beta‐lactam antibiotic and potent activator of the Pregnane X receptor (PXR), known to induce CYP2C9, CYP2C19, and CYP3A4 activity. Clinical data suggest it reduces anticoagulation in warfarin‐treated patients and increases the risk of thromboembolic events.
Chanan Shaul, Waseem Mujahed, Ibrahim Idries, Maor Wanounou, Meir Bialer, Yoseph Caraco   +5 more
wiley   +1 more source

Enantiomer separation using membrane systems [PDF]

, 2002
Many compounds applied in the agrochemical, food and pharmaceutical industry contain one or more chiral centers. The enantiomers of these compounds often have different effects on their targets.
van der Ent, E., Ent, E.M., van der, Ent, E., van der   +2 more
core  

An Investigation Into the Yields of 3,4‐Methylenedioxyphenyl‐2‐propanone (MDP2P) From Glycidate Pre‐Precursors

Drug Testing and Analysis, EarlyView.
Hydrolysis of the glycidate pre‐precursors MMDMG and EMDMG was evaluated for MDP2P production. Acid hydrolysis of MMDMG (HCl, 100°C, 18 h) yielded the highest MDP2P recovery (79%), whereas base hydrolysis produced only slightly lower yields (73%), demonstrating both pathways are effective routes to this key MDMA precursor.
Alexandra L. Mercieca, Ella S. Schuett, Andrew M. McDonagh, Shanlin Fu, Morgan Alonzo   +4 more
wiley   +1 more source

Synthetic Strategies for the Construction of Cyclobutane‐Fused Heterocycles

European Journal of Organic Chemistry, EarlyView.
Cyclobutane‐fused heterocycles are important motifs commonly present in bioactive compounds, recognized for their rigid 3D structures that confer unique properties. However, synthesizing these compounds remains challenging. This review discusses current methods for their synthesis, such as photochemical, metal‐catalyzed, and Lewis acid‐mediated [2 + 2]
Michela Vargiu, Mauro Uras, Angelo Frongia   +2 more
wiley   +1 more source

Conversion of Alcohols to Alkyl Chlorides Using the Bichloride Ionic Liquid [NEt3Me][Cl(HCl)n]

European Journal of Organic Chemistry, EarlyView.
The ionic liquid [NEt3Me][Cl(HCl)1.61] is presented as a controllable source of HCl for the effective transformation of a broad range of alcohols into alkyl chlorides. The process eliminates the need for continuous handling of HCl gas and enables a recyclable IL‐based catalyst system. The solvent‐free chlorination of alcohols using the bichloride‐based
Justus H. Peter, Piet de Jong, Merlin Kleoff, Gesa H. Dreyhsig, Jan‐H. Dickoff, Mohsen Adeli, Sebastian Riedel, C. Christoph Tzschucke, Rainer Haag   +8 more
wiley   +1 more source

Competing Charge Transport Pathways: A Spirobifluorene‐Based Molecular Loop

European Journal of Organic Chemistry, EarlyView.
A rigid molecular loop integrating a spirobifluorene (SBF) core with a cycloparaphenylene (CPP) moiety provides two distinct transport channels. Through‐space spiroconjugation and radial π‐conjugation along a CPP backbone coexist within a single molecule.
Brian Ogi, Riccardo Conte, Salome L. Heim, Herre S. J. van der Zant, Marcel Mayor   +4 more
wiley   +1 more source

Resolution Approaches Toward Enantiopure Planar Chiral 7‐bromo‐4‐hydroxy [2.2]paracyclophane

European Journal of Organic Chemistry, EarlyView.
This work describes access to both enantiomers of planar chiral 7‐bromo‐4‐hydroxy [2.2]paracyclophane through direct resolution of the racemate using an L‐isoleucine‐derived chiral auxiliary or through resolution of 4‐hydroxy [2.2]paracyclophane, followed by regioselective bromination.
Arthur Le Coz, Thomas Desclais, Fabien Le Cavelier, Jean‐François Lohier, Cyprien Lemouchi, Stéphane Perrio   +5 more
wiley   +1 more source

Coated and Immobilized Polysaccharides‐Based Stationary Phases for Planar Metallocenes Enantioseparation in Liquid Chromatography

ELECTROPHORESIS, EarlyView.
This study examined 21 new ferrocene and ruthenocene derivatives, including those with planar and central chirality. Their stereochemical behavior was examined using UV‐detected normal‐phase liquid chromatography. Under fixed conditions, eight polysaccharide‐based chiral stationary phases were tested using n‐heptane combined with either 2‐propanol or ...
Florine Wartelle, Rose Leblond, Lisa Bonin, Alina Ghinet, Emmanuelle Lipka   +4 more
wiley   +1 more source