Results 91 to 100 of about 75,325 (204)
Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future
Medicinal Research Reviews, EarlyView.ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu +15 more
wiley +1 more source
The continuing significance of chiral agrochemicals
Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley +1 more source
, 2014 Robert Hermann,1 Julius Mungo,2 Peter Jürgen Cnota,2 Dan Ziegler3 1Clinical Research Appliance (cr appliance), Gelnhausen, Germany; 2MEDA Pharma GmbH & Co KG, Bad Homburg, Germany; 3Institute for Clinical Diabetology, German Diabetes Center ...
Ziegler D, Hermann R, Cnota PJ, Mungo J
core
Phytotherapy Research, EarlyView.Graphical representation of ethnomedical uses, major bioactive compounds, pharmacological potential and toxicological risks of Ruta graveolens L. ABSTRACT Ruta graveolens L. is widely used in traditional European, Asian, African, and South American medicine for digestive, nervous, cardiovascular, respiratory, and reproductive disorders.
Tetiana Serhiienko +3 more
wiley +1 more source
Application of Natural and Modified Biomacromolecules in Miniaturised Separative Analytical Techniques [PDF]
In pharmaceutical R & D, drug stereochemistry, and consequently the rotation of enantiomers, is very important. Because they act as chiral selectors in vivo, biomacromolecules have been extensively used as chiral selectors for the liquid chromatographic (
Salmon, Andrew B
core +1 more source
Rapid Chiral Analysis of Drugs with Multiple Stereocenters via High-Resolution Ion Mobility. [PDF]
Anal ChemBlakley BK +4 more
europepmc +1 more source
Small, EarlyView.Homochiral bifacial indacenodithiophene (IDT)‐based hole‐transport materials form amorphous spin‐coated films showing pronounced chirality‐induced spin selectivity (CISS) with spin polarization ≈ 60%, and reveal a robust chirality–spin‐polarity correspondence.
Shuang Li +3 more
wiley +1 more source
Macrocycle Conformational Flexibility as a Key to Enantioselective Recognition. [PDF]
JACS AuCabral TLG, Stein M, Tormena CF.
europepmc +1 more source
Small, EarlyView.Supramolecular helicity meets ferroelectricity: P3HT‐b‐PMMA helical nanowires enable handedness‐specific modulation of remanent polarization in P(VDF‐TrFE) hybrids. This platform demonstrates the first CPL‐addressable ferroelectric PUF, translating molecular chirality into secure digital authentication.
Jung‐Min Ji +7 more
wiley +1 more source