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Enantiomer fractions instead of enantiomer ratios [PDF]
Chemosphere, 2000 The use of enantiomer ratios (ERs) to indicate the relative amounts of a pair of enantiomers in a sample has some disadvantages. Enantiomer fractions (EFs) are proposed as all alternative expression to eliminate the difficulties.
Boer, J. de +3 more
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Enantioselective analysis of metoprolol in plasma of hypertensive patients undergoing long-term therapy: Insights for personalized medicine [PDF]
BioImpactsIntroduction: Metoprolol is therapeutically formulated as a racemate with stereoselective pharmacokinetics influenced by CYP2D6 polymorphism. Understanding enantioselective disposition is critical for optimizing therapy in hypertensive patients ...
Behrouz Seyfinejad +4 more
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Chiral drugs - a standard or a challenge for modern pharmacy? Considerations on selected derivatives of 2-arylpropionic acid. [PDF]
Farmacja Polska, 2022 : The US Food and Drug Administration (FDA) stated in 1992, which drew attention to the importance of chiral drugs. Enantiomers, which are optical isomers of a molecule with a stereogenic center, most often have different pharmacological and ...
Natalia Kocot +4 more
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Pharmaceuticals, 2021 Chiral total syntheses of both enantiomers of the anti-MRSA active plymuthipyranone B and all of the both enantiomers of three unnatural and synthetic analogues were performed.
Mizuki Moriyama +4 more
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Pharmaceuticals, 2021 8-Aminoquinolines (8-AQs) are an important class of anti-infective therapeutics. The monoamine oxidases (MAOs) play a key role in metabolism of 8-AQs. A major role for MAO-A in metabolism of primaquine (PQ), the prototypical 8-AQ antimalarial, has been ...
Narayan D. Chaurasiya +5 more
doaj +1 more source
Molecules, 2021 Enzymes, receptors, and other binding molecules in biological processes can recognize enantiomers as different molecular entities, due to their different dissociation constants, leading to diverse responses in biological processes. Enantioselectivity can
Maria Miguel Coelho +3 more
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Chiral Flavonoids as Antitumor Agents
Pharmaceuticals, 2021 Flavonoids are a group of natural products with a great structural diversity, widely distributed in plant kingdom. They play an important role in plant growth, development and defense against aggressors.
Cláudia Pinto +3 more
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Natural Enantiomers: Occurrence, Biogenesis and Biological Properties
Molecules, 2022 The knowledge that natural products (NPs) are potent and selective modulators of important biomacromolecules (e.g., DNA and proteins) has inspired some of the world’s most successful pharmaceuticals and agrochemicals.
Jin-Hai Yu +3 more
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Marine Drugs, 2020 Four new indolyl diketopiperazines, aspamides A–E (1–4) and two new diketopiperazines, aspamides F–G (5–6), along with 11 known diketopiperazines and intermediates were isolated from the solid culture of Aspergillus versicolor, which is an endophyte with
Yi Ding +5 more
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Medical Sciences Forum, 2022 Liver damage is a common issue associated with synthetic cathinones abuse. Indeed, human stem cell-derived hepatocyte-like cells (HLCs) have been used as alternative in vitro models for hepatotoxicity studies, due to their ability to maintain a stable ...
Barbara Silva +6 more
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