Results 201 to 210 of about 56,768 (286)

Dynamical refinement against 3D‐ED data in Olex2–AutoChem using the N‐Beam approach

Journal of Applied Crystallography, EarlyView.
Dynamical diffraction effects in electron diffraction can now be modelled directly within Olex2–AutoChem using data processed with CrysAlisPro, enabled by a new N‐Beam refinement method based on the Bloch‐wave formalism. This workflow allows dynamical refinement of integrated rotation electron diffraction intensities, improving structural models and ...
Oleg Dolomanov, Grzegorz Próchniak, Przemysław Steć, Mathias Meyer, Horst Puschmann   +4 more
wiley   +1 more source

Inducing Enantioselectivity in Radiative Charge-Transfer Rates through Chiral Quantum Electrodynamic Fluctuations. [PDF]

J Phys Chem Lett
Wei YC, Hsu LY.
europepmc   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Enantioselectivity of Isomerization of <i>n</i>-Humulone to <i>trans</i>- and <i>cis</i>-<i>n</i>-Isohumulones. [PDF]

Molecules
Hamper BC, Giovine G, Jagan R, Smith T.
europepmc   +1 more source

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

Macrocycle Conformational Flexibility as a Key to Enantioselective Recognition. [PDF]

JACS Au
Cabral TLG, Stein M, Tormena CF.
europepmc   +1 more source

Selective excitatory effects of γ‐glutamyl‐glycine, a glutathione metabolite, on GluN1 NMDA and mGlu5 receptors impacting synaptic plasticity

British Journal of Pharmacology, EarlyView.
Background and Purpose Gamma‐glutamyl dipeptides are essentially produced after glutathione (GSH) degradation. While several γ‐glutamyl dipeptides have been detected in different organs and body fluids, their biological activity remains elusive. This is the case for γ‐Glutamyl‐Glycine (γ‐Glu‐Gly) which has been found in different brain areas.
Sandro Andreu, Victoria Gizzi, Ugo Pasco, Fatiha Sebih, Yattou Zitouni, Pablo Jimenez, Valérie Rolland, Alain Chavanieu, Sébastien Estaran, Matthieu Rousset, Thierry Cens, Guillaume Cazals, Pierre Charnet, Janique Guiramand, Catherine Cohen‐Solal, Claudine Ménard, Marie‐Céleste de Jésus Ferreira, Nathalie Chevallier, Sonia Cantel, Michel Vignes, Julien Roussel   +20 more
wiley   +1 more source

Concise Total Synthesis and Pharmacological Evaluation of Procerones A and B. [PDF]

ACS Pharmacol Transl Sci
Janneschütz J, Gartlgruber PB, Weissenstein P, Aczel C, Herkner VM, Shtepani C, Haller C, Bacowsky Y, Aslam F, Gashi L, Eraña H, Fuentes-Monteverde JC, Abel S, Simić S, Wackerlig-Damle J, Grünweller A, Griesinger C, Castilla J, Khom S, Schützenmeister N.   +19 more
europepmc   +1 more source

The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1

The FEBS Journal, EarlyView.
ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu, Maximilian J. L. J. Fürst, Oscar P. Kuipers   +2 more
wiley   +1 more source

Capillary Electrophoretic Enantioseparation of Profens: Advances in Chiral Selectors, Separation Strategies, and Analytical Applications. [PDF]

Molecules
Hancu G, Matean M, Cârje AG.
europepmc   +1 more source