Results 31 to 40 of about 86,276 (266)
Alternative Kullback-Leibler information entropy for enantiomers [PDF]
, 2010 In our series of studies on quantifying chirality, a new chirality measure is proposed in this work based on the Kullback-Leibler information entropy.
Borgoo, Alex +4 more
core +2 more sources
Stereochemistry‐Controlled Supramolecular Architectures of New Tetrahydroxy‐Functionalised Amphiphilic Carbocyanine Dyes [PDF]
, 2020 The syntheses of novel amphiphilic 5,5′,6,6‐tetrachlorobenzimidacarbocyanine (TBC) dye derivatives with aminopropanediol head groups, which only differ in stereochemistry (chiral enantiomers, meso form and conformer), are reported.
Berlepsch, Hans von +6 more
core +1 more source
Molecules, 2021 This review draws attention to the use of chiral monolithic silica HPLC columns for the enantiomeric separation and determination of chiral compounds.
Mufarreh Asmari +7 more
doaj +1 more source
Total Chiral Symmetry Breaking during Crystallization: Who needs a "Mother Crystal"? [PDF]
, 2005 Processes that can produce states of broken chiral symmetry are of particular interest to physics, chemistry and biology. Chiral symmetry breaking during crystallization of sodium chlorate occurs via the production of secondary crystals of the same ...
Cristobal Viedma +7 more
core +3 more sources
A Novel Chiral Phase of Achiral Hard Triangles and an Entropy-Driven Demixing of Enantiomers [PDF]
, 2015 We investigate the phase behavior of a system of hard equilateral and right-angled triangles in two dimensions using Monte Carlo simulations. Hard equilateral triangles undergo a continuous isotropic-triatic liquid crystal phase transition at packing ...
Dijkstra, Marjolein +2 more
core +5 more sources
Acta Pharmaceutica, 2019 The relative contribution of CYP2C9 allelic variants to the pharmacokinetics (PK) of ibuprofen (IBP) enantiomers has been studied extensively, but the potential clinical benefit of pharmacogenetically guided IBP treatment is not evident yet.
Kapedanovska Nestorovska Aleksandra +7 more
doaj +1 more source
Molecules, 2017 Amlodipine (AML) is available as a racemate, i.e., a mixture of R- and S-enantiomers. Its inhibitory potency towards nine cytochromes P450 (CYP) was studied to evaluate the drug–drug interactions between the enantiomers.
Kristyna Krasulova +2 more
doaj +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 The copper-catalysed azide-alkyne cycloaddition was applied to prepare three enantiomeric pairs of heterodimers containing a tacrine residue and a 1,4-dideoxy-1,4-imino-D-arabinitol (DAB) or 1,4-dideoxy-1,4-imino-L-arabinitol (LAB) moiety held together ...
I. Caroline Vaaland +7 more
doaj +1 more source
Focus on chirality of HIV-1 non-nucleoside reverse transcriptase inhibitors [PDF]
, 2016 Chiral HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) are of great interest since one enantiomer is often more potent than the corresponding counterpart against the HIV-1 wild type (WT) and the HIV-1 drug resistant mutant strains.
Famiglini, Valeria, Silvestri, Romano
core +2 more sources
Pharmaceuticals, 2022 Pentedrone and methylone can express stereoselectivity in toxicokinetic and toxicodynamic processes. Similarly, their chiral discrimination in metabolism, which was not yet evaluated, can result in different metabolic profiles and subsequent hepatotoxic ...
Bárbara Silva +7 more
doaj +1 more source