Results 61 to 70 of about 32,089 (279)

1‐Azabicyclo[1.1.0]butanes (ABBs) on the Map: Mechanistic Pathways for Catalytic Ring Opening and Functionalizations

Angewandte Chemie, EarlyView.
Catalytic strain‐release ring opening and functionalizations of 1‐azabicyclo[1.1.0]butanes (ABBs) represent a promising strategy for accessing diverse azetidine products. These transformations proceed via polar pathways, radical pathways, and hybrid mechanisms that combine both.
James Shao‐Jiun Yang, Hsuan‐Hung Liao   +1 more
wiley   +2 more sources

Chiral sulfide and achiral sulfonic acid cocatalyzed enantioselective electrophilic tandem selenylation semipinacol rearrangement of allenols

Nature Communications
A highly enantioselective electrophilic selenylation/semipinacol rearrangement of allenols has been developed, which is enabled by the cooperative catalysis of a chiral sulfide and an achiral sulfonic acid.
Ren-Fei Cao, Ruirui Su, Zheng-Wei Wei, Ze-Long Li, Deng Zhu, Yu-Xuan Huo, Xiao-Song Xue, Zhi-Min Chen   +7 more
doaj   +1 more source

Enantioselective Extraction of Ofloxacin Enantiomers Using Ester Alcohol L-Tartarate as Chiral Selector [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2009
The distribution behavior of ofloxacin enantiomers was examined in the aqueous and organic solvent of a two-phase system containing chiral selector L-tartarate.
Xiaoqing Chen Feipeng Jiao, Xinyu Jiang
doaj  

Oligomerization of optically active N-(4-hydroxyphenyl)mandelamide in the presence of β-cyclodextrin and the minor role of chirality

Beilstein Journal of Organic Chemistry, 2014
The oxidative oligomerization of a chiral mandelamide derivative (N-(4-hydroxyphenyl)mandelamide, 1) was performed in the presence of horseradish peroxidase, laccase and N,N'-bis(salicylidene)ethylenediamine-iron(II) to obtain chiral oligophenols 2.
Helmut Ritter, Antonia Stöhr, Philippe Favresse   +2 more
doaj   +1 more source

Effect of Binding on Enantioselectivity of Epoxide Hydrolase

, 2018
Molecular dynamics simulations and free energy calculations have been used to investigate the effect of ligand binding on the enantioselectivity of an epoxide hydrolase (EH) from Aspergillus niger.
Mikael Bodén (2079712), Alan E. Mark (535969), Alpeshkumar K. Malde, Julian Zaugg (4867477), Yosephine Gumulya, Zaugg, Julian, Julian Zaugg, Yosephine Gumulya (2287078), Mikael Bodén, Boden, Mikael, Mark, Alan E, Alan E. Mark, Malde, Alpeshkumar K, Gumulya, Yosephine, Alpeshkumar K. Malde (721736)   +14 more
core   +1 more source

Enantioselective Access to Trifluoromethylated Spirocyclopropyl Heterocycles

Advanced Science, EarlyView.
We report a rhodium‐catalyzed asymmetric [2+1] spirocyclopropanation of methylene azacycles with trifluoromethyl carbenes in situ derived from fluoroalkyl triftosylhydrazones. ABSTRACT Chiral spirocyclopropyl heterocycles have emerged as privileged three‐dimensional structural motifs in medicinal chemistry.
Yuanhao Zhu, Youzhi Xu, Weitao Zhang, Yongyue Ning, Yaojia Jiang, Yongquan Ning, Genping Huang, Jiawei Cheng, Paramasivam Sivaguru, Xihe Bi   +9 more
wiley   +1 more source

Active Metal Template Synthesis of Rotaxanes From BINOL‐Phosphate Macrocycles

Angewandte Chemie, EarlyView.
The use of macrocyclic BINOL‐phosphates allows for the active metal template synthesis of [2]rotaxanes via Cu(I)‐mediated alkyne‐azide cycloaddition. DFT calculations, control experiments, and kinetic experiments support a dinuclear phosphate‐Cu2 intermediate.
Nikolai Brodt, Sophia Stadtfeld, Somayyeh Kheirjou, Tibor Schumski, Adrian M. Bialowons, Dennis Jansen, Felix Niemeyer, Torsten Schaller, Gebhard Haberhauer, Jan Riebe, Jochen Niemeyer   +10 more
wiley   +2 more sources

Molecular Characterization of a Novel Cold-Active Hormone-Sensitive Lipase (HaHSL) from Halocynthiibacter Arcticus

Biomolecules, 2019
Bacterial hormone-sensitive lipases (bHSLs), which are homologous to the catalytic domains of human HSLs, have received great interest due to their uses in the preparation of highly valuable biochemicals, such as drug intermediates or chiral building ...
Ly Thi Huong Luu Le, Wanki Yoo, Changwoo Lee, Ying Wang, Sangeun Jeon, Kyeong Kyu Kim, Jun Hyuck Lee, T. Doohun Kim   +7 more
doaj   +1 more source

Comparative Analysis of the Conversion of Mandelonitrile and 2-Phenylpropionitrile by a Large Set of Variants Generated from a Nitrilase Originating from Pseudomonas fluorescens EBC191

Molecules, 2019
The arylacetonitrilase from the bacterium Pseudomonas fluorescens EBC191 has been intensively studied as a model to understand the molecular basis for the substrate-, reaction-, and enantioselectivity of nitrilases.
Andreas Stolz, Erik Eppinger, Olga Sosedov, Christoph Kiziak   +3 more
doaj   +1 more source

Titration and assignment of residues that regulate the enantioselectivity of phenylacetone monooxygenase [PDF]

, 2007
Phenylacetone monooxygense (PAMO) from Thermobifida fusca was employed for the asymmetric oxidation of thioanisole (sulfooxidation) and of racemic 2-phenylpropionaldehyde (Baeyer–Villiger oxidation).
Ottolina, Gianluca, Gianluca Ottolina, Zambianchi, Francesca, Cristina Rodríguez, Gonzalo de Gonzalo, Giacomo Carrea, de Gonzalo, Gonzalo, Carrea, Giacomo, Vicente Gotor, Marco W. Fraaije, Fraaije, Marco W., Rodriguez, Cristina, Gotor, Vicente, Francesca Zambianchi, Gotor Santamaría, Vicente Miguel, Gonzalo Calvo, Gonzalo de, de Gonzalo G, Rodriguez C, Rodríguez González, Cristina, Zambianchi F, Ottolina G, Gotor V, Carrea G, Fraaije MW   +23 more
core   +1 more source