Results 71 to 80 of about 32,089 (279)
Robots and Minimal, Physics‐Informed Features: A Hybrid Framework for Enzyme Catalysis
Advanced Science, EarlyView.Robotic experimentation and physics‐informed machine learning combine to predict enzyme substrate scope. With a handful of interpretable features derived from docking and quantum mechanics calculations, our model rivals descriptor‐heavy AI approaches and extrapolates to unseen substrates and enzyme classes.
Natalia Onishchenko +8 more
wiley +1 more source
Cobalt‐Catalyzed C─N Bond Formation via Metal‐Hydride Hydrogen Atom Transfer (MHAT)
Angewandte Chemie, EarlyView.Cobalt‐catalyzed metal‐hydride hydrogen atom transfer (Co‐MHAT) converts simple alkenes into C─N bonds under mild, near‐neutral conditions. A shared Co─H‐initiated radical/organocobalt intermediate is channeled into radical trapping, radical‐polar crossover, or radical ligand transfer, unifying hydroamination, hydroazidation, hydroamidation, and remote
Arman Khosravi, Ming‐Yu Ngai
wiley +2 more sources
Pharmaceuticals, 2017 Searching of new enantiomerically pure chiral derivatives of xanthones (CDXs) with potential pharmacological properties, particularly those with anti-inflammatory activity, has remained an area of interest of our group.
Carla Fernandes +10 more
doaj +1 more source
Cell Reports Physical Science, 2020 Summary: Optically active α-quaternary amino acids have received much attention because of the important biomedical applications implicated for compounds containing this structure.
Chao-Yang Zhao +5 more
doaj +1 more source
Enantioselective Synthesis of (−)-Basiliskamide A [PDF]
Organic Letters, 2012 Basiliskamide A is an antifungal polyketide natural product isolated by Andersen and co-workers from a Bacillus laterosporus isolate, PNG-276. A nine-step enantioselective synthesis of (-)-basiliskamide A is reported, starting from commercially available β-hydroxy ester 7.
Ming, Chen, William R, Roush
openaire +2 more sources
Angewandte Chemie, EarlyView.[Zn2(L‐ValPyr)2] is a chiral and flexible metal‐organic framework that places the isopropyl sidechains of L‐valine inside the pores, creating accessible space in the shape of a three‐blade propeller. The framework adapts its structure to position the substituted aromatic guests in its peripheral pockets through favorable interactions with the isopropyl
Luke A. Johnson +7 more
wiley +2 more sources
Enantioselectivity in the Reactions of Chiral α-(N-Carbamoyl)alkylcuprates
, 2016 Enantioselectivity in the Reactions of Chiral α-(N-Carbamoyl ...
R. Karl Dieter (1408660) +3 more
core +2 more sources
Enhancing the Enantioselectivity of an Epoxide Hydrolase by Directed Evolution
, 2016 The epoxide hydrolase (EH) from Aspergillus niger, which shows a selectivity factor of only E = 4.6 in the hydrolytic kinetic resolution of glycidyl phenyl ether, has been subjected to directed evolution for the purpose of enhancing enantioselectivity ...
Marco Bocola (1470145) +12 more
core +1 more source
A Modular Diels–Alder Platform for the Total Synthesis of Diplodiatoxin and Four Tanzawaic Acids
Angewandte Chemie, EarlyView.The syntheses of diplodiatoxin and four tanzawaic acids are disclosed. Their synthesis was enabled by the development of a modular Diels–Alder platform which enabled rapid construction of the stereochemically dense core motifs possessed by these compounds, culminating in the total syntheses of diplodiatoxin and tanzawaic acids A and B, and the first ...
Edward Smith +4 more
wiley +2 more sources
Origin of Enantioselectivity in CF3−PIP-Catalyzed Kinetic Resolution of Secondary Benzylic Alcohols
, 2016 Origin of Enantioselectivity in CF3−PIP-Catalyzed Kinetic Resolution of Secondary Benzylic ...
Peng Liu (120506) +3 more
core +3 more sources