Results 191 to 200 of about 19,236 (236)

Endocannabinoids

Česká gynekologie, 2021
Objective: Overview of current knowledge in the field of the endocannabinoid system with emphasis on the relationships between endocannabinoids and exocannabinoids. The endocannabinoid system consists of cannabinoid receptors 1 and 2, ligands of these receptors, especially two "classical" endocannabinoids N-arachidonoylethanolamine (anandamide) and 2 ...
Josef, Suchopár   +4 more
openaire   +2 more sources

Endocannabinoids

European Journal of Pharmacology, 1998
The background knowledge leading to the isolation and identification of anandamide and 2-arachidonoyl glycerol, the principal endocannabinoids is described. The structure-activity relationships of these lipid derivatives are summarized. Selected biochemical and pharmacological topics in this field are discussed, the main ones being levels of ...
R, Mechoulam, E, Fride, V, Di Marzo
openaire   +2 more sources

The endocannabinoid system

Essays in Biochemistry, 2020
Abstract Thirty years ago, the discovery of a cannabinoid (CB) receptor that interacts with the psychoactive compound in Cannabis led to the identification of anandamide, an endogenous receptor ligand or endocannabinoid. Research on endocannabinoids has since exploded, and additional receptors along with their lipid mediators and ...
Aruna Kilaru, Kent D. Chapman
openaire   +3 more sources

From endocannabinoid profiling to ‘endocannabinoid therapeutics’

Current Opinion in Chemical Biology, 2009
The discovery of the endocannabinoid signalling system, that is, of cannabinoid receptors, their endogenous ligands, known as endocannabinoids, and of endocannabinoid anabolic and catabolic enzymes, raised several questions regarding the physiopathological role of these mediators. Several of these questions were answered by investigating alterations in
Ligresti A, Petrosino S, Di Marzo V
openaire   +4 more sources

Endocannabinoids and Neuroprotection

Science's STKE, 2002
Traumatic brain injury (TBI) releases harmful mediators that lead to secondary damage. On the other hand, neuroprotective mediators are also released, and the balance between these classes of mediators determines the final outcome after injury. Recently, it was shown that the endogenous brain cannabinoids anandamide and 2-Arachidonoyl glycerol (2-AG ...
R, Mechoulam, M, Spatz, E, Shohami
openaire   +2 more sources

Endocannabinoids and sleep

Neuroscience & Biobehavioral Reviews, 2016
Sleep is regulated by several brain structures, neurotransmitters and neuromodulators. Endocannabinoids (eCBs) are a group of lipids with modulatory activity in the brain and bind mainly to cannabinoid receptors CB1R and CB2R, thereby modulating several brain functions, (memory, mood, food intake, pain perception).
Oscar, Prospéro-García   +4 more
openaire   +2 more sources

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