Results 201 to 210 of about 19,236 (236)
Some of the next articles are maybe not open access.
Endocannabinoids and Nutrition
Journal of Neuroendocrinology, 2008The endocannabinoids anandamide (AEA) and 2‐arachidonoylglycerol (2‐AG) are bioactive lipids derived from the n‐6 family of polyunsaturated fatty acids that are essential fatty acids. Symptoms of essential fatty acid deficiency in rats – growth retardation, scaly skin, and increased transepidermal water loss – can mainly be attributed to lack of ...
Hansen, Harald S., Artmann, Andreas
openaire +3 more sources
Endocannabinoids and pregnancy
Clinica Chimica Acta, 2010Acylethanolamides such as anandamide (AEA), and monoacylglycerols like 2-arachidonoylglycerol are endocannabinoids that bind to cannabinoid, vanilloid and peroxisome proliferator-activated receptors. These compounds, their various receptors, the purported membrane transporter(s), and related enzymes that synthesize and degrade them are collectively ...
Taylor, AH +7 more
openaire +4 more sources
Prostaglandins & Other Lipid Mediators, 2002
Endocannabinoids (endogenous ligands of cannabinoid receptors) such as anandamide (N-arachidonoylethanolamine) and 2-arachidonoylglycerol (2-AG) are inactivated upon enzymatic hydrolysis. Recent progress in the enzymological and molecular biological studies on the 'endocannabinoid hydrolases' is reviewed in this article.
openaire +2 more sources
Endocannabinoids (endogenous ligands of cannabinoid receptors) such as anandamide (N-arachidonoylethanolamine) and 2-arachidonoylglycerol (2-AG) are inactivated upon enzymatic hydrolysis. Recent progress in the enzymological and molecular biological studies on the 'endocannabinoid hydrolases' is reviewed in this article.
openaire +2 more sources
Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2002
In the digestive tract, there is evidence for the presence of high amounts of endocannabinoids (anandamide and 2-arachidonylglycerol) and of mechanisms for endocannabinoid metabolism and possibly endocannabinoid uptake. Pharmacological studies have shown that anandamide inhibits excitatory transmission and peristalsis in the isolated guinea-pig ileum ...
PINTO L +3 more
openaire +3 more sources
In the digestive tract, there is evidence for the presence of high amounts of endocannabinoids (anandamide and 2-arachidonylglycerol) and of mechanisms for endocannabinoid metabolism and possibly endocannabinoid uptake. Pharmacological studies have shown that anandamide inhibits excitatory transmission and peristalsis in the isolated guinea-pig ileum ...
PINTO L +3 more
openaire +3 more sources
Endocannabinoids and their actions
2002Endocannabinoids are a new class of lipid mediators, which includes amides and esters of long-chain polyunsaturated fatty acids. Anandamide (I) and 2-arachidonoylglycerol (II) are the main endogenous agonists of cannabinoid receptors, able to mimic several pharmacological effects of delta 9-tetrahydrocannabinol (III), the active principle of Cannabis ...
Maccarrone M, Finazzi-Agro A
openaire +3 more sources
Phytocannabinoids and Endocannabinoids
Current Drug Abuse Reviewse, 2009Progress in understanding the molecular mechanisms of cannabis action was made after discovery of cannabinoid receptors in the brain and the finding of endogenous metabolites with affinity to them. Activation of cannabinoid receptors on synaptic terminals results in regulation of ion channels, neurotransmitter release and synaptic plasticity ...
openaire +2 more sources
2015
A large body of evidence shows that cannabinoids, in addition to their well-known palliative effects on some cancer-associated symptoms, can reduce tumour growth in animal models of cancer. They do so by modulating key cell signalling pathways involved in the control of cancer cell proliferation and survival.
Guillermo, Velasco +2 more
openaire +2 more sources
A large body of evidence shows that cannabinoids, in addition to their well-known palliative effects on some cancer-associated symptoms, can reduce tumour growth in animal models of cancer. They do so by modulating key cell signalling pathways involved in the control of cancer cell proliferation and survival.
Guillermo, Velasco +2 more
openaire +2 more sources
2013
A safe and effective antiobesity drug is needed to combat the global obesity epidemic. The discovery of cannabinoids from medicinal herbs has revealed the endocannabinoid system (ECS) in animals and humans, which regulates various physiological activities such as feeding, thermogenesis, and body weight (BW).
Guoxun, Chen, Zhen, Pang
openaire +2 more sources
A safe and effective antiobesity drug is needed to combat the global obesity epidemic. The discovery of cannabinoids from medicinal herbs has revealed the endocannabinoid system (ECS) in animals and humans, which regulates various physiological activities such as feeding, thermogenesis, and body weight (BW).
Guoxun, Chen, Zhen, Pang
openaire +2 more sources
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2006
The endocannabinoid system is a complex physiologic system. One of the most important discoveries related to the endocannabinoid system is that cannabinoid‐1 receptors are present throughout the body and that they are linked to obesity and cardiometabolic risk. Adipose tissue was historically thought to be an inert, passive storage vehicle.
openaire +2 more sources
The endocannabinoid system is a complex physiologic system. One of the most important discoveries related to the endocannabinoid system is that cannabinoid‐1 receptors are present throughout the body and that they are linked to obesity and cardiometabolic risk. Adipose tissue was historically thought to be an inert, passive storage vehicle.
openaire +2 more sources
ENDOCANNABINOIDS AND THE NEUROCHEMISTRY OF GLUTTONY
Journal of Neuroendocrinology, 2008SummaryCannabis exerts its actions by mimicking ‘endocannabinoid’ neuromodulators at CB1 receptors in brain and peripheral tissues. The endocannabinoids both stimulate appetite by increasing food craving and enjoyment and promote the deposition of energy as fat in adipose tissues. These findings have raised the possibility of CB1 antagonists as a novel
openaire +2 more sources