Results 91 to 100 of about 2,670,563 (294)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Endocrine Phosphate Resistance

, 2016
Calcium and phosphate homeostasis in healthy individuals and in Teutschlaender's disease caused by endocrine phosphate resistance.
Johannes Wolfgang Christian Dietrich (3192570)
core   +1 more source

Genomic hallmarks of endocrine therapy resistance in ER/PR+HER2- breast tumours

Communications Biology
ER/PR+HER2- breast tumours are the most predominant subtype of breast cancer worldwide, including India. Unlike TNBCs, these tumours can be treated with anti-estrogens or aromatase inhibitors.
Arnab Ghosh, Rohan Chaubal, Chitrarpita Das, Pallavi Parab, Subrata Das, Arindam Maitra, Partha P. Majumder, Sudeep Gupta, Nidhan K. Biswas   +8 more
doaj   +1 more source

In Silico Design of Dual Estrogen Receptor and Hsp90 Inhibitors for ER-Positive Breast Cancer Through a Mixed Ligand/Structure-Based Approach

Molecules
Breast cancer remains one of the most prevalent and lethal malignancies in women, particularly the estrogen receptor-positive (ER+) subtype, which accounts for approximately 70% of cases.
Gabriele La Monica, Federica Alamia, Alessia Bono, Francesco Mingoia, Annamaria Martorana, Antonino Lauria   +5 more
doaj   +1 more source

Cardiovascular complications in insulin resistance and endocrine diseases

Endocrine Journal, 2023
Cerebrovascular diseases, such as stroke and cardiovascular disease, are one of the leading causes of death in Japan. Type 2 diabetes is the most common form of diabetes and an important risk factor for these diseases. Among various pathological conditions associated with type 2 diabetes, insulin resistance has already been reported to be an important ...
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Interaction of GPER-1 with the endocrine signaling axis in breast cancer

Frontiers in Endocrinology
G Protein-Coupled Estrogen Receptor 1 (GPER-1) is a membrane estrogen receptor that has emerged as a key player in breast cancer development and progression.
Luis Molina Calistro, Yennyfer Arancibia, Marcela Alejandra Olivera, Sigrid Domke, Rodrigo Flavio Torres   +4 more
doaj   +1 more source

Editorial: Resistance to Endocrine Therapies in Cancer [PDF]

Frontiers in Endocrinology, 2020
Ranganathan P., Chakrabarty A., Hiscox S., Limaye A. M., Vella V.   +4 more
openaire   +4 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Blockade of AP-1 potentiates endocrine therapy and overcomes resistance [PDF]

, 2016
UnlabelledThe transcription factor AP-1 is downstream of growth factor (GF) receptors (GFRs) and stress-related kinases, both of which are implicated in breast cancer endocrine resistance.
Schiff, Rachel, MIGLIACCIO, ILENIA, Fu, Xiaoyong, Wang, Tao, Healy, Nuala, Osborne, C Kent, MALORNI, LUCA, GIULIANO, MARIO, Mazumdar, Abhijit, Brown, Powel H, Hilsenbeck, Susan G., DE ANGELIS, CARMINE, Jeselsohn, Rinath, Kent Osborne, C., Massarweh, Suleiman, Creighton, Chad J, Lupien, Mathieu, Trivedi, Meghana V, Brown, Myles, DE PLACIDO, SABINO, Creighton, Chad J., Gutierrez, Carolina, Hilsenbeck, Susan G, Trivedi, Meghana V., Brown, Powel H.   +24 more
core   +1 more source