Results 191 to 200 of about 2,670,563 (294)

The role of UPR-related long noncoding RNAs in development of endocrine resistance in breast cancer. [PDF]

Int J Cancer
Liu W, Gupta S, Gupta S.
europepmc   +1 more source

CDK4/6 Inhibitors-Overcoming Endocrine Resistance Is the Standard in Patients with Hormone Receptor-Positive Breast Cancer. [PDF]

Cancers (Basel), 2023
Nabieva N, Fasching PA.
europepmc   +1 more source

Large‐scale Whole‐Exome Sequencing Defines the Protein‐Coding Architecture of Retinal Structure, Visual Function, and Major Blinding Diseases

Advanced Science, EarlyView.
Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li, Yijun Ge, Jingxiao Du, Liu Yang, Bangsheng Wu, Chenyue Hang, Mengxi Shen, Yimin Mao, Ting Zhang, Qiyu Bo, Tianyuan Zhao, Yutian Jiao, Yazhi Wang, Shunxiang Gao, Jieqiong Chen, Junran Sun, Tong Li, Huixun Jia, Yang Dou, Wei Cheng, Xiaoling Wan, Jintai Yu, Xiaodong Sun, Bai Lu   +23 more
wiley   +1 more source

Assessing endocrine resistance: monitoring circulating ESR1 mutations in Irosustat-treated ER positive breast cancer. [PDF]

Breast Cancer Res Treat
Page K, Martinson LJ, Hastings RK, Acheampong E, Wadsley MK, Allsopp RC, Luo JL, Coombes RC, Shaw JA, Palmieri C.   +9 more
europepmc   +1 more source

RRM2 and CDC6 are novel effectors of XBP1-mediated endocrine resistance and predictive markers of tamoxifen sensitivity. [PDF]

BMC Cancer, 2023
Barua D, Sultana A, Islam MN, Cox F, Gupta A, Gupta S.   +5 more
europepmc   +1 more source

Ubiquitination of ACSL4 by Parkin Suppresses Ferroptosis and Rescues Glucocorticoid‐Induced Bone Loss

Advanced Science, EarlyView.
GCs reduce Parkin, leading to ACSL4 accumulation and PUFA‐phospholipid‐driven ferroptosis in BMSCs, which impairs osteogenesis and promotes adipogenesis, causing GIOP. Parkin restoration (via OE‐Parkin or Parkin‐LNP@DSS6) ubiquitinates and degrades ACSL4, inhibiting ferroptosis, rescuing bone formation, and rescues GIOP bone loss.
Li‐jiang Han, Jian‐sen Miao, Yi‐feng Shi, Yi‐ting Tu, Yu‐zhe Lin, Lin‐Jie Chen, Bing‐hao Lin, Hua‐lin Li, Xuan‐qi Zheng, Hong‐qiang Wu, Hai‐xiao Liu, Lei Yang, Ai‐min Wu, Zhen Lin, Jian Xiao, Gang Zheng, Chen Jin   +16 more
wiley   +1 more source

Estrogen receptor alpha dynamics and plasticity during endocrine resistance. [PDF]

Biol Direct
Sivasailam A, Kumar KS, Jayaprasad AG, Jancy SV, Harikumar A, Unnikrishnan PS, Sivakumar KC, Tiffee PJJ, Halikar AM, Nithin SS, Pillai PR, Tiwari SK, Sanjeev VS, Surabhi AV, Santhoshkumar TR.   +14 more
europepmc   +1 more source

Hypoxia and ERα Transcriptional Crosstalk Is Associated with Endocrine Resistance in Breast Cancer. [PDF]

Cancers (Basel), 2022
Jehanno C, Le Goff P, Habauzit D, Le Page Y, Lecomte S, Lecluze E, Percevault F, Avner S, Métivier R, Michel D, Flouriot G.   +10 more
europepmc   +1 more source

An Artificially Selected Cytokinin‐Pathway Transcription Factor Balances Soybean Yield and Pathogen Resistance

Advanced Science, EarlyView.
A cytokinin pathway transcription factor, RR2b, was artificially selected during soybean domestication and improvement based on its differential transcriptional activity, which correlates with ATT repeat polymorphisms in its promoter. RR2b balances yield and defense by fine‐tuning its expression level and offers a promising target for decoupling trade ...
Qun Ma, Yaqing Chen, Yiwen Gao, Xueting Hu, Qun Yang, Yucheng Liu, Peiyong Xin, Jijun Yan, Jinfang Chu, Lei Li, Zhixi Tian, Bo Ren   +11 more
wiley   +1 more source

SIZ1‐Mediated SUMOylation of LBD29 Recruits ARF7 to Fine‐Tune Auxin Signaling in Lateral Root Development

Advanced Science, EarlyView.
Our findings establish SUMOylation as a key post‐translational control layer in auxin signaling. We show that SIZ1‐mediated SUMOylation of LBD29 promotes its association with ARF7, stabilizing a transcriptional hub that governs lateral root development.
Jiaxuan Sui, Qianlan Yin, Yiying Chen, Liping Zhang, Xiuyuan Yu, Qianqian Yu, Zhaojun Ding, Xiangpei Kong   +7 more
wiley   +1 more source