Results 61 to 70 of about 119,873 (307)

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

Evaluation of the reliability and readability of ChatGPT-4 responses regarding hypothyroidism during pregnancy

Scientific Reports
Hypothyroidism is characterized by thyroid hormone deficiency and has adverse effects on both pregnancy and fetal health. Chat Generative Pre-trained Transformer (ChatGPT) is a large language model trained with a very large database from many sources ...
C. E. Onder, G. Koc, P. Gokbulut, I. Taskaldiran, S. M. Kuskonmaz   +4 more
doaj   +1 more source

Gender-Related Factors in Medication Adherence for Metabolic and Cardiovascular Health

, 2023
This review explores the impact of gender on medication adherence in the context of metabolic and cardiovascular diseases. Optimal adherence to medication is crucial for achieving treatment goals and preventing adverse outcomes in chronic diseases.
Tiziana Filardi, Enrico Bleve, Susanna Morano, Vittorio Venditti   +3 more
core   +1 more source

A Novel Reactive Oxygen Species‐Responsive Bone‐Targeted Nanoplatform Based on Cloperastine Attenuates Ovariectomy‐Induced Bone Loss by Inhibiting Osteoclast Oxidative Phosphorylation

Advanced Science, EarlyView.
Cloperastine suppresses osteoclastogenesis by inhibiting PGC1β‐mediated oxidative phosphorylation. Its incorporation into a ROS‐responsive, Asp8‐modified nanoplatform enhances skeletal accumulation. The resulting Clo/Asp8‐PMK‐MCs combine cloperastine‐mediated antiresorptive activity with carrier‐mediated osteogenic activity to attenuate OVX‐induced ...
Haibo Liang, Yong Xiao, Jiangtao Luo, Xiao Yang, Yayun Yang, Qihang Wu, Chenxin Yu, Zhihao Zhou, Xiaoqing Si, Jiansen Miao, Yiting Tu, Qichen Lu, Boreng Qian, Xiangyang Wang, Jiake Xu, Changcan Shi, Haiming Jin   +16 more
wiley   +1 more source

Assessment of adequacy of vitamin D supplementation during pregnancy

Annals of Agricultural and Environmental Medicine, 2014
Introduction. Deficiency of vitamin D in pregnancy leads to higher incidences of preeclampsia, gestational diabetes, preterm birth, bacterial vaginosis, and also affects the health of the infants.
Elżbieta Skowrońska-Jóźwiak, Zbigniew Adamczewski, Agnieszka Tyszkiewicz, Kinga Krawczyk-Rusiecka, Krzysztof Lewandowski, Andrzej Lewiński   +5 more
doaj  

Effects of orlistat on APRI and FIB-4 scores in patients with obesity: a retrospective observational study

BMC Endocrine Disorders
Objective Metabolic dysfunction–associated steatotic liver disease (MASLD) is closely associated with obesity and diabetes mellitus (DM). Early identification of patients at risk of liver fibrosis is important for clinical management; however, liver ...
Halil Durantas, Ogulcan Boz, Ceren Karacalik Unver, Neslihan Koray Fedai, Basak Cakal, Sema Hepsen, Erman Cakal   +6 more
doaj   +1 more source

Integrative Management of Metabolic Syndrome in Youth Prescribed Second-Generation Antipsychotics

, 2020
Weight gain and metabolic syndrome are common side effects of second-generation antipsychotics and carry significant health consequences both in childhood and into adulthood.
Jessie Rice, Ujjwal Ramtekkar
core   +1 more source

Thrifty metabolic programming in rats is induced by both maternal undernutrition and postnatal leptin treatment, but masked in the presence of both: implications for models of developmental programming. [PDF]

, 2014
BACKGROUND Maternal undernutrition leads to an increased risk of metabolic disorders in offspring including obesity and insulin resistance, thought to be due to a programmed thrifty phenotype which is inappropriate for a subsequent richer nutritional ...
Stewart Gilmour, Morris, Tiffany J., Vickers, Mark H., Nabeel A Affara, Gilmour, Stewart, Benjamin M Skinner, Sargent, Carole A., Mark H Vickers, Peter D Gluckman, Affara, Nabeel A., Ellis, Peter J.I., Skinner, Benjamin M., Peter JI Ellis, Tiffany J Morris, Carole A Sargent, Gluckman, Peter D.   +15 more
core   +2 more sources

Hepatocyte CBX2 Safeguards Hepatic Lipid Homeostasis by Elevating Ca2+‐CaMKK2‐AMPK Signaling to Counter MASLD

Advanced Science, EarlyView.
In hepatocytes, CBX2 promotes H3K4me3 enrichment at the Orai1 promoter to enhance Orai1 transcriptional activation, thereby increasing intracellular Ca2+ levels. The elevated Ca2+ activates the CaMKK2‐AMPK signaling cascade, resulting in ACC phosphorylation and downstream metabolic regulation. This cascade suppresses de novo lipogenesis (Fasn, Acc, Scd‐
Xiang Wei, Li Lin, Xiuyun Wang, Hui Du, Menglong Zhang, Kechao Tang, Han Gao, Xinrui Xie, Jingya Gao, Xu Wang, Zhenglin Wang, Siwei Huang, Lei Zhang, Fang Gu, Gong‐Hong Wei, Yinliang Qi, Wei Chen, Yongsheng Chang, Huabing Zhang   +18 more
wiley   +1 more source

Metastatic Papillary Thyroid Carcinoma Masked by Diffuse Parenchymal Calcification

Endocrinology Research and Practice, 2014
A patient with papillary thyroid carcinoma most commonly presents with a thyroid nodule or cervical lymphadenopathy. The ultrasonographic features of malign nodules are well known by the clinicians.
Melia Karaköse, Oya Topaloğlu, Taner Demirci, Müyesser Sayki Arslan, Mustafa Özbek, Mustafa Şahin, Tuncay Delibaşı   +6 more
doaj   +1 more source