Results 81 to 90 of about 119,873 (307)

Drug-centric hierarchical clustering of diseases.

, 2016
One hundred forty-one diseases from the Trial dataset were clustered using a distance metric based on the drugs adopted by each disease. The Trial manually-created classification included the categories: autoimmune/inflammation (blue-green ...
Raul Rodriguez-Esteban (257885)
core   +1 more source

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

Central Hypothyroidism with Low TSH Compared to Normal TSH Is Associated with More Advanced Pituitary Disease and Less Favorable Metabolic Profile

Background: Central hypothyroidism is characterized by either decreased TSH or, more commonly, normal TSH. This study aims to check whether this biochemical difference related to the severity of the pituitary disease, metabolic processes and general well-
Małgorzata Karbownik-Lewińska, Jan Stępniak, Aleksandra E. Matusiak, Andrzej Lewiński, Krzysztof C. Lewandowski   +4 more
core   +1 more source

Sequential catalytic nanosystem of carbon dots and uricase integrated with polydopamine for therapy of gouty wound ulceration

BMEMat, EarlyView.
Sequential dual‐catalytic treatment of the gout wound ulceration process by CDs‐Uri@PDA. (a) Synthesis steps and morphology of CDs‐Uri@PDA. (b) Sequential treatment process and mechanism of CDs‐Uri@PDA for gout wound ulceration according to (i) uric acid reduction, (ii) antibacterial activity, and (iii) anti‐inflammatory effects.
Yonglan Yang, Yang Yang, Pengpeng Ma, Ruiqi Zhu, Xia Pan, Shaoling Zheng, Bo Chen, Yanli Jin, Youcong Gong, Jie Liu, Tianwang Li, Xu Chen   +11 more
wiley   +1 more source

A novel marker for predicting malignancy in patients with thyroid nodules diagnosed as AUS on initial cytology: thyroid hormone sensitivity

Frontiers in Endocrinology
PurposeThis study aimed to evaluate the predictive value of thyroid hormone sensitivity indices and hematological inflammatory markers, in addition to ultrasonographic features, for malignancy in thyroid nodules initially classified as atypia of ...
Puren Gokbulut, Cagatay Emir Onder, Serife Mehlika Kuskonmaz, Huseyin Yagcı, Cavit Culha, Gonul Koc   +5 more
doaj   +1 more source

Dapagliflozin in Type 2 Diabetes Patients in Routine Internal Medicine and Endocrinology Outpatient Clinical Care; A Retrospective Cohort Study from Turkey

Endocrinology Research and Practice, 2018
Background and Aims: The present study aimed to describe characteristics of patients with type 2 diabetes (T2D) initiated on dapagliflozin in routine outpatient clinical care in Turkey, post-dapagliflozin changes in glycated hemoglobin (HbA1c), body ...
Derun Taner Ertuğrul, Erdal Kan, Çiğdem Bahadır Tura, Hacı Bayram Tuğtekin, Hayati Ayakta, Mehmet Çelebioğlu, Timuçin Demiralp, Onur Utebay, İlhan Yetkin   +8 more
doaj   +1 more source

Glycopolymeric nanoparticles transported by activated platelets protect ischemic myocardium by alleviating PANoptosis through targeting macrophage Dectin‐1

BMEMat, EarlyView.
NP‐SF, designed to target macrophage Dectin‐1 and activated platelets, selectively accumulated in ischemic myocardium, where it was taken up by macrophages after platelet hitchhiking. By inhibiting NLRC5‐related PANoptosis, NP‐SF significantly attenuated pathological damage, and effectively preserved cardiac function in a murine ischemia–reperfusion ...
Guanye Yu, Na Yang, Yan Zhang, Lingxin Peng, Yi Li, Yue Chao, Qinfang Miao, Haikun Qi, Jianhui Zhuang, Weixia Jian, Bingyu Li, Wenhui Peng, Jinghua Chen, Shiyu Gong   +13 more
wiley   +1 more source

Advances in the Identification of Novel Urinary Biomarkers for Diabetic Kidney Disease

Journal of Diabetes Research
Diabetic kidney disease (DKD) is a major microvascular complication of diabetes and remains one of the leading causes of end-stage renal disease, significantly affecting patients' survival rates and quality of life.
Yujie Jin, Yan Ma, Yan Yao, Mengru Wang, Chunchen Ni, Shujuan Shang, Yongxin Cui, Xinyu Wang, Ye Ling, Yumeng Sun, Qirui Pei, Shiqiang Liu, Lizhuo Wang, Jialin Gao   +13 more
doaj   +1 more source

Cognitive performance in chronic postoperative hypoparathyroidism: A cross-sectional study

Northwestern Medical Journal
Objective: To evaluate cognitive performance in patients with chronic postoperative hypoparathyroidism and to investigate its association with biochemical parameters.
Püren Gökbulut, Şerife Ezgi Doğan, Çağatay Emir Önder, Işılay Taşkaldıran, Cavit Çulha, Tülay Omma   +5 more
doaj   +1 more source

PGC-1α and exercise in the control of body weight [PDF]

, 2012
The increasing prevalence of obesity and its comorbidities represents a major threat to human health globally. Pharmacological treatments exist to achieve weight loss, but the subsequent weight maintenance is prone to fail in the long run.
Summermatter, S., Handschin, C., S Summermatter, C Handschin, Summermatter S, Handschin C   +5 more
core   +1 more source