Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery. [PDF]
, 2017 Neurite initiation is the first step in neuronal development and occurs spontaneously in soft tissue environments. Although the mechanisms regulating the morphology of migratory cells on rigid substrates in cell culture are widely known, how soft ...
Chang, Ting-Ya +9 more
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FEBS Open Bio, EarlyView.In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna +4 more
wiley +1 more source
Clathrin-mediated endocytosis cooperates with bulk endocytosis to generate vesicles
iScience, 2022 Summary: Clathrin-mediated endocytosis, the most prominent endocytic mode, is thought to be generated primarily from relatively flat patches of the plasma membrane.
Gianvito Arpino +9 more
doaj
Spatial segregation of BMP/Smad signaling affects osteoblast differentiation in C2C12 cells.
PLoS ONE, 2011 BackgroundBone morphogenetic proteins (BMPs) are involved in a plethora of cellular processes in embryonic development and adult tissue homeostasis.
Eva Heining +4 more
doaj +1 more source
Clathrin- and dynamin-independent endocytosis of FGFR3--implications for signalling. [PDF]
PLoS ONE, 2011 Endocytosis of tyrosine kinase receptors can influence both the duration and the specificity of the signal emitted. We have investigated the mechanisms of internalization of fibroblast growth factor receptor 3 (FGFR3) and compared it to that of FGFR1 ...
Ellen Margrethe Haugsten +6 more
doaj +1 more source
Loss of flotillin expression results in weakened desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes [PDF]
, 2016 Desmosomes are adhesion plaques that mediate cell-cell adhesion in many tissues, including the epidermis, and generate mechanical resistance to tissues. The extracellular domains of desmosomal cadherin proteins, desmogleins and desmocollins, are required
Ali, Jawahir +7 more
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Vacuolar ATPase depletion contributes to dysregulation of endocytosis in bloodstream forms of Trypanosoma brucei [PDF]
, 2020 BACKGROUND Vacuolar H-ATPase (V-ATPase) is a highly conserved protein complex which hydrolyzes ATP and pumps protons to acidify vacuolar vesicles.
Hide, G +4 more
core +2 more sources
Endocytosis, Signaling, and Beyond [PDF]
Cold Spring Harbor Perspectives in Biology, 2014 The endocytic network comprises a vast and intricate system of membrane-delimited cell entry and cargo sorting routes running between biochemically and functionally distinct intracellular compartments. The endocytic network caters to the organization and redistribution of diverse subcellular components, and mediates appropriate shuttling and processing
P.P. Di Fiore, M. von Zastrow
openaire +3 more sources
Matrix: a complex amalgam of structures and functions in tumor microenvironment
FEBS Open Bio, EarlyView.The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Spyros S. Skandalis +3 more
wiley +1 more source
Modulation of sleep by trafficking of lipids through the Drosophila blood-brain barrier
eLife, 2023 Endocytosis through Drosophila glia is a significant determinant of sleep amount and occurs preferentially during sleep in glia of the blood-brain barrier (BBB).
Fu Li, Gregory Artiushin, Amita Sehgal
doaj +1 more source