Results 111 to 120 of about 40,712 (254)

Three-Dimensional Trilineage Differentiation Conditions for Human Induced Pluripotent Stem Cells

Bioengineering
Human induced pluripotent stem cells (hiPSCs) hold great potential for regenerative medicine. However, optimizing their differentiation into specific lineages within three-dimensional (3D) scaffold-based culture systems that mimic in vivo environments ...
Md Sharifur Rahman, Guangyan Qi, Quan Li, Xuming Liu, Jianfa Bai, Mingshun Chen, Anthony Atala, Xiuzhi Susan Sun   +7 more
doaj   +1 more source

INTRACARDIAC ENDODERMAL HETEROTOPIA [PDF]

Heart, 1962
M, HONEY, M A, AXELRAD
openaire   +2 more sources

The dental plate on bichir pectoral fins: A unique dermal skeletal element bearing individual odontodes with tooth‐like replacement

Journal of Anatomy, Volume 249, Issue 1, Page 127-140, July 2026.
Pectoral fins of bichirs encompass the so‐called dental plates – unique dermal skeletal elements with individual odontodes identical to the oral teeth. Abstract The dermal skeleton appeared early in vertebrate evolution in the form of mineralized skin denticles composed of tooth‐like units—odontodes.
Tomáš Suchánek, Ann Huysseune, Robert Cerny   +2 more
wiley   +1 more source

A molecular pathway leading to endoderm formation in zebrafish

, 1999
Background: Several potentially important regulators of vertebrate endoderm development have been identified, including Activin-related growth factors and their receptors; transcriptional regulators encoded by the genes Mixer, Xsox17, and HNF3β ...
Stainier, Didier Y.R., Didier Y.R. Stainier, Alexander, Jonathan, Jonathan Alexander   +3 more
core   +1 more source

Ethanol Induces Craniofacial Defects in Bmp Mutants Independent of nkx2.3 by Elevating Cranial Neural Crest Cell Apoptosis

Biomedicines
Background: Craniofacial malformations lie at the heart of fetal alcohol spectrum disorders (FASDs). While there is growing evidence for a genetic component in FASDs, little is known of the cellular mechanisms underlying these ethanol-sensitive loci in ...
Hieu D. L. Vo, C. Ben Lovely
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, Volume 16, Issue 6, Page 1102-1114, June 2026.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Endoderm Complexity in the Mouse Gastrula Is Revealed Through the Expression of Spink3

, 2014
Endoderm formation in the mammalian embryo occurs first in the blastocyst, when the primitive endoderm and pluripotent cells resolve into separate lineages, and again during gastrulation, when the definitive endoderm progenitor population emerges from ...
Goh, HN, Rathjen, PD, Rathjen, J, Familari, M   +3 more
core   +1 more source

Tissue‐Stimulator Platform for Electrically Stimulating Pancreatic β‐Cells for Long‐Term Functional Regulation

Advanced Functional Materials, Volume 36, Issue 49, 18 June 2026.
We present a tissue‐stimulator platform for seamless electrode integration with pancreatic tissue, applying uniform electrical stimulation through optimized design with biohybrid 3D printing. Advantageous effects of electrical stimulation on β‐cell function were observed, including enhanced calcium signaling, islet morphology, and maturation.
Jihwan Kim, Uijung Yong, Myungji Kim, Jaewook Kim, Yeonggwon Jo, In Kyong Shim, Song Cheol Kim, Jinah Jang   +7 more
wiley   +1 more source

Regulation of lung endoderm progenitor cell behavior by miR302/367

, 2011
The temporal and spatial control of organ-specific endoderm progenitor development is poorly understood. miRNAs affect cell function by regulating programmatic changes in protein expression levels.
Feiyan Liu, Min Min Lu, Yuzhen Zhang, Laura Hurd, Ying Tian, Edward E. Morrisey, Sridhar Hannenhalli   +6 more
core   +1 more source

ELABELA Targets Mitochondria to Modulate Heart Development

Advanced Science, Volume 13, Issue 33, 15 June 2026.
The role of peptide ELABELA (ELA) in cardiomyocyte apoptosis and congenital heart disease (CHD) is unclear. ELA deficiency caused cardiomyocyte apoptosis and CHD. A novel ELA‐APJ‐AKT‐BCL2/BAX axis in regulating mitochondrial function and contributing to CHD pathogenesis was established.
Jian Wang, Qingjie Wang, Zhikang Xu, Shuang Zhou, Yue Zhou, Junjie Yang, Lingfeng Tong, Zhuo Meng, Mei Yang, Wen Zhao, Tie Yang, Hualin Wang, Jun Zhang, Rubin Tan, Lei Wang, Yuqiang Huang, Bin Zhou, Sun Chen, Bing Zhang, Jinxiang Yuan, Jianyuan Zhao, Alex F. Chen, Kun Sun   +22 more
wiley   +1 more source