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piRNA Defense Against Endogenous Retroviruses [PDF]
VirusesInfection by retroviruses and the mobilization of transposable elements cause DNA damage that can be catastrophic for a cell. If the cell survives, the mutations generated by retrotransposition may confer a selective advantage, although, more commonly ...
Milky Abajorga +2 more
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How Active Are Porcine Endogenous Retroviruses (PERVs)? [PDF]
Viruses, 2016 Porcine endogenous retroviruses (PERVs) represent a risk factor if porcine cells, tissues, or organs were to be transplanted into human recipients to alleviate the shortage of human transplants; a procedure called xenotransplantation.
Joachim Denner
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Reactivated endogenous retroviruses promote protein aggregate spreading
Nature Communications, 2023 Prion-like spreading of protein misfolding is a characteristic of neurodegenerative diseases, but the exact mechanisms of intercellular protein aggregate dissemination remain unresolved.
Shu Liu +7 more
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Nature Communications, 2023 The contribution of transposable elements and endogenous retroviruses to renal fibroinflammation is currently unknown. Here, the authors comprehensively profile the expression of transposable elements and endogenous retroviruses (ERVs) in kidneys of ...
Poonam Dhillon +9 more
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Diversity and evolutionary history of endogenous retroviruses in the genome of Manis pentadactyla [PDF]
Microbiology SpectrumEndogenous retroviruses (ERVs), remnants of ancient viral infections integrated into host genomes, serve as invaluable molecular fossils for studying viral evolution.
Tiancheng Zhang +4 more
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Human Endogenous Retroviruses and Diseases [PDF]
MedCommHuman endogenous retroviruses (HERVs), remnants of ancient retroviral infections, comprise nearly 8% of the human genome and play dual roles in physiological regulation and disease pathogenesis.
Can Chen +9 more
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Endogenous Retroviruses as Modulators of Innate Immunity
Pathogens, 2023 Endogenous retroviruses (ERVs), or LTR retrotransposons, are a class of transposable elements that are highly represented in mammalian genomes. Human ERVs (HERVs) make up roughly 8.3% of the genome and over the course of evolution, HERV elements ...
Eric Russ, Sergey Iordanskiy
doaj +2 more sources
Porcine Endogenous Retroviruses and Xenotransplantation, 2021
Viruses, 2021 Porcine endogenous retroviruses (PERVs) are integrated in the genome of all pigs, and some of them are able to infect human cells. Therefore, PERVs pose a risk for xenotransplantation, the transplantation of pig cells, tissues, or organ to humans in ...
Joachim Denner
doaj +2 more sources
Human Endogenous Retroviruses in Neurodegenerative Diseases [PDF]
Genes (Basel)Human endogenous retroviruses (HERVs) are DNA transposable elements that have integrated into the human genome via an ancestral germline infection. The potential importance of HERVs is underscored by the fact that they comprise approximately 8% of the ...
Adler G, Le K, Fu Y, Kim W.
europepmc +2 more sources
Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses [PDF]
Nature Medicine, 2018 Mesenchymal tumor subpopulations secrete pro-tumorigenic cytokines and promote treatment resistance1-4. This phenomenon has been implicated in chemorefractory small cell lung cancer and resistance to targeted therapies5-8, but remains incompletely ...
Israel Cañadas +2 more
exaly +3 more sources