The proteome of the human endolymphatic sac endolymph [PDF]
Scientific Reports, 2021 The endolymphatic sac (ES) is the third part of the inner ear, along with the cochlea and vestibular apparatus. A refined sampling technique was developed to analyse the proteomics of ES endolymph. With a tailored solid phase micro-extraction probe, five
Christine Ölander +5 more
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Endolymphatic sac surgery: past and present controversies [PDF]
Frontiers in NeurologyThe history of endolymphatic sac surgery is presented. The original concept of passive drainage is challenged as the physiology of the endolymphatic sac is gradually elucidated.
W. P. R. Gibson
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MRI-based measurement of inner ear fluids reveals increased endolymph volume variability in patients with endolymphatic hydrops and hearing instability [PDF]
Scientific ReportsLack of proven biomarkers for hearing instability (HI) disorders leads to difficulty and delays in diagnosis. Given the association of HI with endolymphatic hydrops (EH), imaging-based techniques for quantification of endolymph and perilymph may be ...
Julia Telischi +8 more
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Protein profile of mouse endolymph suggests a role in controlling cochlear homeostasis [PDF]
iScienceSummary: The cochlea contains two extracellular fluids, perilymph and endolymph. Endolymph exhibits high potential of approximately +80 to +110 mV (depending on species), which sensitizes sensory hair cells.
Masatoshi Fukuda +11 more
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A minimal ion–chemistry model for predicting benign paroxysmal positional vertigo risk based on endolymphatic calcium and pH [PDF]
Frontiers in NeurologyBenign paroxysmal positional vertigo (BPPV) arises from detachment of otoconia—calcium carbonate (CaCO3) crystals embedded in a protein matrix—whose stability depends on endolymph ionic composition and pH.
Dong-Gyun Han
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7-Tesla sodium magnetic resonance imaging of the inner ears in unilateral Ménière’s disease and endolymphatic hydrops: an exploratory study [PDF]
BMC Medical ImagingBackground Whilst delayed post-gadolinium MRI has led to a shift in the diagnostic paradigm of Meniere’s Disease (MD), there remains a strong desire to develop a non-contrast enhanced MRI technique to detect and monitor MD.
Steve Connor +6 more
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Complete omission of exon 21 from Slc12a2 transcripts in mice results in hearing loss [PDF]
Scientific ReportsHereditary hearing loss is highly heterogeneous. SLC12A2 is linked to autosomal dominant nonsyndromic hearing loss, DFNA78, with all the pathogenic variants affecting the exon 21.
Hideki Mutai +8 more
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Navigating Hereditary Hearing Loss: Pathology of the Inner Ear
Frontiers in Cellular Neuroscience, 2021 Inherited forms of deafness account for a sizable portion of hearing loss among children and adult populations. Many patients with sensorineural deficits have pathological manifestations in the peripheral auditory system, the inner ear.
Teresa Nicolson
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Incidence of Hypothyroidism in Meniere’s Disease [PDF]
Journal of Clinical and Diagnostic Research, 2016 Introduction: Meniere’s disease is a disorder of the membranous labyrinth of the inner ear manifesting as vertigo, tinnitus, sensory neural hearing loss and aural fullness of known or unknown origin.
U.P. Santosh, M.S. Sudhakar Rao
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Volume quantification of endolymphatic hydrops in patients with vestibular schwannoma
NeuroImage: Clinical, 2021 Objective: The origin of vestibular symptoms in patients with vestibular schwannoma (VS) is uncertain. We used intratympanic gadolinium-enhanced magnetic resonance imaging (MRI) to confirm the labyrinthine lesions in patients with VS and to explore the ...
Jingjing Wang +8 more
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