Results 41 to 50 of about 5,024 (177)

Jervell and Lange‐Nielsen Syndrome Related Clinical Genetics and Experimental Models

Pediatric Discovery, EarlyView.
ABSTRACT Jervell and Lange‐Nielsen syndrome (JLNS) is defined by electrocardiographic QT prolongation and sensorineural hearing loss, caused by homozygous or compound heterozygous variants in KCNQ1 and/or KCNE1. KCNQ1 encodes the alpha subunit Kv7.1 of the ion channels accountable for slow delayed rectifier potassium currents (IKs), whereas KCNE1 ...
Yafei Zhou, Christopher L.‐H. Huang, Ying Yang, Yanmin Zhang   +3 more
wiley   +1 more source

Progress On Sensorineural Hearing Loss: Mechanisms and Therapies

Sensory Neuroscience, EarlyView.
ABSTRACT Hearing loss is the most common disabling disease among humans, which adversely affects human health. Sensorineural hearing loss (SNHL) accounting for approximately 63% of all hearing loss cases. SNHL may be classified into age‐related hearing loss (ARHL), drug‐induced hearing loss (DIHL), noise‐induced hearing loss (NIHL), and sudden ...
Yuan Zhang, Shen Li, Yangfan Zhou, Duopin Li, Junru Ding, Ruifeng Qiao, Yutian Chen, Fanglei Ye, Le Wang, Peipei Li   +9 more
wiley   +1 more source

Study the biomechanical performance of the membranous semicircular canal based on bionic models

Heliyon, 2022
A BA (bionic ampulla) was designed and fabricated using an SMPF (Symmetric electrodes Metal core PVDF Fiber) sensor, which could imitate the sensory hair cells to sense the deformation of the cupula of the BA. Based on the BA, a bionic semicircular canal
Yixiang Bian, Shien Lu, Zhi Wang, Yongbin Qin, Jialing Li, Guangming Guo, Junjie Gong, Yani Jiang   +7 more
doaj   +1 more source

Disrupted Vestibular Nuclei Neuron Development in a Chick Model for Congenital Vestibular Disorders

Developmental Neurobiology, Volume 86, Issue 3, July 2026.
ABSTRACT Children with syndromic, congenital vestibular disorders (CVDs) form a sac‐like inner ear with missing or truncated semicircular canals and experience delayed motor development with lifelong challenges to maintain posture and balance. How the abnormal inner ear affects downstream central vestibular neural circuitry has not been investigated ...
Elizabeth B. Bogin, Rossella Conti, Kathleen Gallagher, Kaya Oguz, Anastas Popratiloff, Kenna D. Peusner   +5 more
wiley   +1 more source

Intraspecific variation of cochlear morphology in bowhead and beluga whales

The Anatomical Record, Volume 309, Issue 6, Page 1514-1529, June 2026.
Abstract The bony labyrinth of the petrosal bone, a distinctive feature of mammal skulls, is often identified in micro‐computed tomography imaging to infer species' physiological and ecological traits. When done as part of a comparative study, one individual specimen is normally considered representative of a species, and intraspecific variation is ...
John Peacock, J. G. M. Thewissen
wiley   +1 more source

The effectiveness of microsurgery for Meniere's disease

Сучасні медичні технології, 2021
Meniere's disease is a noninflammatory disease, manifested by episodes of dizziness, nystagmus reaction, vegetative disorders, static disturbances, hearing loss, tinnitus.
A. D. Gusakov, V. V. Skorobogatyi, A. A. Gusakova, D. N. Kokorkin, P. P. Shevluk, N. A. Kolyada   +5 more
doaj   +1 more source

β-trace protein (prostaglandin D synthase) - a stable and reliable protein in perilymph

GMS German Medical Science, 2005
Objective: Beta-trace protein (β-TP) has been analysed in human cerebrospinal fluid (CSF) and other body fluids. Beta-trace protein is a very sensitive and specific clinical marker and can confirm reliably the presence of CSF in patients with a suspected
Nekic, Marko, Bamborschke, Stephan, Michel, Olaf, Bachmann, Gregor   +3 more
doaj  

Critical role of SDF-1/CXCR4 signaling pathway in stem cell homing in the deafened rat cochlea after acoustic trauma

Neural Regeneration Research, 2018
Previous animal studies have shown that stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor-4 (CXCR4) signaling pathway plays an important role in the targeted migration of bone marrow-derived mesenchymal stem cells (BMSCs) to the injured area ...
Ali Asghar Peyvandi, Navid Ahmady Roozbahany, Hassan Peyvandi, Hojjat-Allah Abbaszadeh, Niloofar Majdinasab, Mohammad Faridan, Somayeh Niknazar   +6 more
doaj   +1 more source

Low Endolymph Calcium Concentrations in deafwaddler2J Mice Suggest that PMCA2 Contributes to Endolymph Calcium Maintenance [PDF]

Journal of the Association for Research in Otolaryngology, 2004
In vertebrates, transduction of sound into an electrochemical signal is carried out by hair cells that rely on calcium to perform specialized functions. The apical surfaces of hair cells are surrounded by endolymphatic fluid containing calcium at concentrations that must be maintained by active transport. The mechanism of this transport is unknown, but
J David, Wood, Sara J, Muchinsky, Adelaida G, Filoteo, John T, Penniston, Bruce L, Tempel   +4 more
openaire   +2 more sources

Variants encoding a restricted carboxy-terminal domain of SLC12A2 cause hereditary hearing loss in humans.

PLoS Genetics, 2020
Hereditary hearing loss is challenging to diagnose because of the heterogeneity of the causative genes. Further, some genes involved in hereditary hearing loss have yet to be identified.
Hideki Mutai, Koichiro Wasano, Yukihide Momozawa, Yoichiro Kamatani, Fuyuki Miya, Sawako Masuda, Noriko Morimoto, Kiyomitsu Nara, Satoe Takahashi, Tatsuhiko Tsunoda, Kazuaki Homma, Michiaki Kubo, Tatsuo Matsunaga   +12 more
doaj   +1 more source