Results 1 to 10 of about 5,024 (177)

The proteome of the human endolymphatic sac endolymph [PDF]

Scientific Reports, 2021
The endolymphatic sac (ES) is the third part of the inner ear, along with the cochlea and vestibular apparatus. A refined sampling technique was developed to analyse the proteomics of ES endolymph. With a tailored solid phase micro-extraction probe, five
Christine Ölander, Jesper Edvardsson Rasmussen, Per Olof Eriksson, Göran Laurell, Helge Rask-Andersen, Jonas Bergquist   +5 more
doaj   +4 more sources

Investigation Into the Dynamics of the Cupula in the Vestibular Organ of Adult Zebrafish Using Metabolic Glycoengineering. [PDF]

Angew Chem Int Ed Engl
The cupula is a membrane within the vestibular organ that senses rotatory accelerations of the head. Metabolic glycoengineering in combination with bioorthogonal labeling demonstrates that in adult zebrafish – being a model for the human inner ear – this membrane is constantly renewed.
Scherer H, Jüngst A, Schöwe VF, Gronewald AK, Wittmann V.   +4 more
europepmc   +3 more sources

Endolymphatic sac surgery: past and present controversies [PDF]

Frontiers in Neurology
The history of endolymphatic sac surgery is presented. The original concept of passive drainage is challenged as the physiology of the endolymphatic sac is gradually elucidated.
W. P. R. Gibson
doaj   +2 more sources

MRI-based measurement of inner ear fluids reveals increased endolymph volume variability in patients with endolymphatic hydrops and hearing instability [PDF]

Scientific Reports
Lack of proven biomarkers for hearing instability (HI) disorders leads to difficulty and delays in diagnosis. Given the association of HI with endolymphatic hydrops (EH), imaging-based techniques for quantification of endolymph and perilymph may be ...
Julia Telischi, Dillon Strepay, Bing Li, Jennifer Chisholm, Hui Cheng, Carmen Brewer, Li-Yueh Hsu, John Butman, Michael Hoa   +8 more
doaj   +2 more sources

Protein profile of mouse endolymph suggests a role in controlling cochlear homeostasis [PDF]

iScience
Summary: The cochlea contains two extracellular fluids, perilymph and endolymph. Endolymph exhibits high potential of approximately +80 to +110 mV (depending on species), which sensitizes sensory hair cells.
Masatoshi Fukuda, Hiroki Okanishi, Daisuke Ino, Kazuya Ono, Takeru Ota, Eri Wakai, Takashi Sato, Yumi Ohta, Yoshiaki Kikkawa, Hidenori Inohara, Yoshikatsu Kanai, Hiroshi Hibino   +11 more
doaj   +2 more sources

Electrical Control of the Transduction Channels' Gating Force in Mechanosensory Hair Cells. [PDF]

Adv Sci (Weinh)
The inner ear's hair cells rely on mechanosensitive ion channels to convert vibrations of their hair‐bundle into electrical signals. We show that varying the electrical potential (U) across the sensory epithelium modulates a key determinant of mechanosensitivity—the gating force (FG)—by modulating the gating swing (d), ranging from the size of the ...
Joliot A, Stickel L, Martin P.
europepmc   +2 more sources

A minimal ion–chemistry model for predicting benign paroxysmal positional vertigo risk based on endolymphatic calcium and pH [PDF]

Frontiers in Neurology
Benign paroxysmal positional vertigo (BPPV) arises from detachment of otoconia—calcium carbonate (CaCO3) crystals embedded in a protein matrix—whose stability depends on endolymph ionic composition and pH.
Dong-Gyun Han
doaj   +2 more sources

7-Tesla sodium magnetic resonance imaging of the inner ears in unilateral Ménière’s disease and endolymphatic hydrops: an exploratory study [PDF]

BMC Medical Imaging
Background Whilst delayed post-gadolinium MRI has led to a shift in the diagnostic paradigm of Meniere’s Disease (MD), there remains a strong desire to develop a non-contrast enhanced MRI technique to detect and monitor MD.
Steve Connor, Peter Lally, Irumee Pai, Haneefah Brnawi, Philip Touska, Sebastien Ourselin, Joseph V. Hajnal   +6 more
doaj   +3 more sources

Navigating Hereditary Hearing Loss: Pathology of the Inner Ear

Frontiers in Cellular Neuroscience, 2021
Inherited forms of deafness account for a sizable portion of hearing loss among children and adult populations. Many patients with sensorineural deficits have pathological manifestations in the peripheral auditory system, the inner ear.
Teresa Nicolson
doaj   +1 more source

Incidence of Hypothyroidism in Meniere’s Disease [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Meniere’s disease is a disorder of the membranous labyrinth of the inner ear manifesting as vertigo, tinnitus, sensory neural hearing loss and aural fullness of known or unknown origin.
U.P. Santosh, M.S. Sudhakar Rao
doaj   +1 more source