Results 41 to 50 of about 9,267 (204)

Tmc1 point mutation affects Ca2+ sensitivity and block by dihydrostreptomycin of the mechanoelectrical transducer current of mouse outer hair cells [PDF]

, 2016
The transduction of sound into electrical signals depends on mechanically sensitive ion channels in the stereociliary bundle. The molecular composition of this mechanoelectrical transducer (MET) channel is not yet known.
Corns, Laura F, Johnson, Stuart L, Kros, Corne J, Marcotti, Walter   +3 more
core   +3 more sources

Optimizing the vertebrate vestibular semicircular canal: could we balance any better? [PDF]

, 2004
The fluid-filled semicircular canals (SCCs) of the vestibular system are used by all vertebrates to sense angular rotation. Despite masses spanning seven decades, all mammalian SCCs are nearly the same size.
A. A. Gray, A. J. Hudspeth, A. J. Hudspeth, A. W. Gummer, C. M. Oman, D. A. Baylor, D. E. Hillman, D. E. Parker, G. M. Jones, I. S. Curthoys, J. H. Ten Kate, J. M. Goldberg, L. D. Landau, M. J. Dai, M. King, R. D. Rabbitt, R. L. Lewis, S. Masetto, S. Vogel, S. Vogel, T. A. McMahon, T. Hoshino, W. C. Van Buskirk   +22 more
core   +2 more sources

Perilymphatic fistula with characteristic findings of the inner ear by contrast-enhanced magnetic resonance imaging: a case report

Frontiers in Neurology, 2023
A perilymphatic fistula (PLF) presents with abnormal traffic in the otic capsule, causing cochlear and vestibular symptoms. However, the mechanisms underlying symptom recurrence remain controversial. Herein, we report the case of a 27-year-old female who
Yusuke Ito, Toru Seo, Yoshiyuki Sasano, Fumihiro Mochizuki, Fumihiro Mochizuki, Izumi Koizuka   +5 more
doaj   +1 more source

A hypothetical proposal for association between migraine and Meniere's disease. [PDF]

, 2020
Meniere's disease (MD) is a chronic condition affecting the inner ear whose precise etiology is currently unknown. We propose the hypothesis that MD is a migraine-related phenomenon which may have implications for future treatment options for both ...
Abouzari, Mehdi, Djalilian, Hamid R, Lin, Harrison W, Sarna, Brooke   +3 more
core  

Single-cell RNA-sequencing of stria vascularis cells in the adult Slc26a4 -/- mouse

BMC Medical Genomics, 2023
Background The primary pathological alterations of Pendred syndrome are endolymphatic pH acidification and luminal enlargement of the inner ear. However, the molecular contributions of specific cell types remain poorly characterized.
Jin-Young Koh, Corentin Affortit, Paul T. Ranum, Cody West, William D. Walls, Hidekane Yoshimura, Jian Q. Shao, Brian Mostaert, Richard J.H. Smith   +8 more
doaj   +1 more source

The blood labyrinthine barrier in the human normal and Meniere's disease macula utricle. [PDF]

, 2017
The ultrastructural organization of the blood labyrinthine barrier (BLB) was investigated in the human vestibular endorgan, the utricular macula, using postmortem specimens from individuals with documented normal auditory and vestibular function and ...
Ishiyama, Akira, Ishiyama, Gail, Ishiyama, Paul, Lopez, Ivan A, Vinters, Harry V   +4 more
core   +2 more sources

Investigation Into the Dynamics of the Cupula in the Vestibular Organ of Adult Zebrafish Using Metabolic Glycoengineering

Angewandte Chemie International Edition, EarlyView.
The cupula is a membrane within the vestibular organ that senses rotatory accelerations of the head. Metabolic glycoengineering in combination with bioorthogonal labeling demonstrates that in adult zebrafish – being a model for the human inner ear – this membrane is constantly renewed.
Hans Scherer, Andrea Jüngst, Verena F. Schöwe, Anne‐Katrin Gronewald, Valentin Wittmann   +4 more
wiley   +1 more source

Clinic manifestations in granulomatosis with polyangiitis [PDF]

, 2016
Granulomatosis with polyangiitis (GPA), formerly Wegener's granulomatosis (WG), is an uncommon immunologically mediated systemic small-vessel vasculitis that is pathologically characterised by an inflammatory reaction pattern (necrosis, granulomatous ...
De Vincentiis, Marco, De Virgilio, Armando, Fusconi, Massimo, Gallo, Andrea, Greco, Antonio, Macri, Gian Franco, Marinelli, Caterina, Zambetti, Giampietro   +7 more
core   +1 more source

A perspective from the Mesozoic: Evolutionary changes of the mammalian skull and their influence on feeding efficiency and high‐frequency hearing

The Anatomical Record, EarlyView.
Abstract The complex evolutionary history behind modern mammalian chewing performance and hearing function is a result of several changes in the entire skeletomuscular system of the skull and lower jaw. Lately, exciting multifunctional 3D analytical methods and kinematic simulations of feeding functions in both modern and fossil mammals and their ...
Julia A. Schultz
wiley   +1 more source

Chaotic Dynamics Enhance the Sensitivity of Inner Ear Hair Cells [PDF]

, 2019
Hair cells of the auditory and vestibular systems are capable of detecting sounds that induce sub-nanometer vibrations of the hair bundle, below the stochastic noise levels of the surrounding fluid.
Bozovic, Dolores, Faber, Justin
core   +1 more source