Results 91 to 100 of about 8,598 (217)
Safety Studies of Pneumococcal Endolysins Cpl-1 and Pal [PDF]
Viruses, 2018 Bacteriophage-derived endolysins have gained increasing attention as potent antimicrobial agents and numerous publications document the in vivo efficacy of these enzymes in various rodent models. However, little has been documented about their safety and toxicity profiles.
Marek Harhala +15 more
openaire +3 more sources
Dysbiosis in the Pathogenesis of Atopic Dermatitis
The Journal of Dermatology, Volume 53, Issue 3, Page 388-398, March 2026.ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by epidermal barrier dysfunction and immune dysregulation. Recent research highlights cutaneous dysbiosis as a critical factor in its pathogenesis. In this review, we summarize the interplay between the skin microbiota and host immunity, contrasting the homeostatic ...
Hiroki Okamoto, Yuumi Nakamura
wiley +1 more source
Microbial Biotechnology, Volume 19, Issue 3, March 2026.Major reproductive‐tract microbiome endotypes and their clinical associations. L. crispatus dominance supports acidification and immune tolerance conducive to implantation. L. iners dominance represents an unstable state linked to bacterial vaginosis and reduced implantation.
Limiao Li +9 more
wiley +1 more source
Bacteriophage φEf11 ORF28 Endolysin, a Multifunctional Lytic Enzyme with Properties Distinct from All Other Identified Enterococcus faecalis Phage Endolysins [PDF]
Applied and Environmental Microbiology, 2019 The emergence of multidrug-resistant pathogenic microorganisms has brought increasing attention to the urgent need for the development of alternative antimicrobial strategies. One such alternative to conventional antibiotics employs lytic enzymes (endolysins) that are produced by bacteriophages in the course of lytic infection.
Hongming Zhang +5 more
openaire +2 more sources
The Iraqi Journal of Medical Sciences, 2018 Background: Persistent infection with multidrug resistant Pseudomonas aeruginosa (P. aeruginosa) represents a real problem for health care providers.
Mohammed Ali +2 more
doaj +1 more source
Fish and Fisheries, Volume 27, Issue 2, Page 300-312, March 2026.Bacteriophage therapy is characterised by numerous advantages, facilitating its diverse aquaculture application and efficacy as an antibiotic alternative mitigating the spread of antimicrobial‐resistant pathogens. Contributing to the modern reappraisal of the aquaculture application of bacteriophage therapy, challenges impeding its widespread ...
Louise James +4 more
wiley +1 more source
Expanding Horizons in Phage Therapy: Addressing Antibiotic Resistance in Aquaculture
Aquaculture, Fish and Fisheries, Volume 6, Issue 1, February 2026.ABSTRACT Aquaculture has emerged as a cornerstone of global food security, yet its rapid intensification has precipitated widespread bacterial disease outbreaks and escalating antimicrobial resistance (AMR). This review critically examines the limitations of conventional antibiotic use in aquaculture, highlighting regulatory inconsistencies ...
Anisah Azhar +3 more
wiley +1 more source
Characterization of PlyPl23, an endolysin from a Paenibacillus larvae bacteriophage [PDF]
, 2014 EMBO Conference on Viruses of Microbes III: Structure and Function - from Molecules to Communities (Programme and Abstract Book)Bees pollination presents a great impact in a wide range of terrestrial ecosystems.
Azeredo, Joana +4 more
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Advanced Healthcare Materials, Volume 15, Issue 2, 14 January 2026.Thiolated hyaluronic acid (HAMS) synthesized and characterized by NMR, solubility, thiol content, and pKa, is degraded by Staphylococcal hyaluronate lyase but not by mammalian hyaluronidase. Coating polyphosphate–M23 phage endolysin nanoparticles (M23‐PP) with HAMS confers Staphylococcus aureus responsiveness.
Mariana Blanco Massani +11 more
wiley +1 more source
Antibacterial activity on opportunistic Pseudomonas aeruginosa pathogen by a novel Salmonella phage endolysin [PDF]
, 2011 The Gram-negative pathogen Pseudomonas aeruginosa can cause severe infections of burn wound or cystic fibrosis on patients. Bacteriophage endolysin based strategy can offer a new alternative antimicrobial therapy.
Azeredo, Joana +5 more
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