Results 91 to 100 of about 4,149 (194)

Potential for Bacteriophage Endolysins to Supplement or Replace Antibiotics in Food Production and Clinical Care [PDF]

, 2018
There is growing concern about the emergence of bacterial strains showing resistance to all classes of antibiotics commonly used in human medicine. Despite the broad range of available antibiotics, bacterial resistance has been identified for every ...
Michael Love, Bhandari, D., Michael J. Love, Renwick C. J. Dobson, Renwick Dobson, Love, M., Dobson, R.C.J., Dinesh Bhandari, Craig Billington, Billington, C.   +9 more
core   +1 more source

The Unique Capability of Endolysin to Tackle Antibiotic Resistance: Cracking the Barrier

Journal of Xenobiotics
The lack of new antibacterial medicines and the rapid rise in bacterial resistance to antibiotics pose a major threat to individuals and healthcare systems.
Abdus Sabur, Angkan Khan, B. Borphukan, Abdur Razzak, M. Salimullah, Muslima Khatun   +5 more
doaj   +1 more source

Phages of Listeria offer novel tools for diagnostics and biocontrol

Frontiers in Microbiology, 2014
Historically, bacteriophages infecting their hosts have perhaps been best known and even notorious for being a nuisance in dairy-fermentation processes.
Martin J Loessner, Steven eHagens
doaj   +1 more source

From endolysins to Artilysin®s: novel enzyme-based approaches to kill drug-resistant bacteria

, 2016
One of the last untapped reservoirs in nature for the identification of new anti-microbials is bacteriophages, the natural killers of bacteria. Lytic bacteriophages encode peptidoglycan (PG) lytic enzymes able to degrade the PG layer in different steps ...
Rodríguez-Rubio, Lorena, Briers, Yves, Lavigne, Rob, Gerstmans, Hans   +3 more
core   +1 more source

Endolysins and Their Potential in Combating Bacterial Multidrug Resistance

Frontiers in Bioscience-Elite
Since the discovery of penicillin in 1928, more than a thousand antibiotics have been introduced into medical practice. Initially, the introduction of antibiotics revolutionized the treatment of infectious diseases. However, as antibiotics have been used
Olga I. Guliy, Olga A. Karavaeva
doaj   +1 more source

Functional and structural in silico characterization of endolysins encoded by the novel lytic coliphage ASEC2201 isolated from a wastewater treatment plant

Cleaner Water
Background: The increasing prevalence of multidrug-resistant (MDR) Escherichia coli in environmental and clinical settings necessitates alternative antibacterial strategies beyond conventional antibiotics.
Sudhaker Padmesh, Humaira Saeed, Aditi Singh, Manodeep Sen   +3 more
doaj   +1 more source

Domain organization of mycobacteriophage endolysins.

, 2012
Each of the mycobacteriophage endolysins is designated according to the presence (+) or absence (−) of each of three domain types: an N-terminal domain (N1, N2, N3, N4, N5, M23), a central catalytic domain (Ami-2A, Ami-2B, GH19, GH25, or TG), and a C ...
Graham F. Hatfull (174881), Kimberly M. Payne (174876)   +1 more
core   +1 more source

Endolysins for precision antimicrobial therapy and rapid bacterial detection: translational challenges and future directions

Frontiers in Pharmacology
Antimicrobial resistance (AMR) represents a major global health challenge, necessitating the development of alternative therapeutic and diagnostic strategies.
Fazal Mehmood Khan, Mohammed Zourob
doaj   +1 more source

CRISPR-Cas9 engineered Saccharomyces cerevisiae for endolysin delivery to combat Listeria monocytogenes

Applied Microbiology and Biotechnology
Listeriosis is an infection caused by the consumption of food contaminated with Listeria monocytogenes. It leads to febrile gastroenteritis, central nervous system infections, and even death in risk populations.
David Sáez Moreno, Joana Cunha, Luís Daniel Rodrigues de Melo, Kenya Tanaka, Takahiro Bamba, Tomosiha Hasunuma, Joana Azeredo, Lucília Domingues   +7 more
doaj   +1 more source

Breaking barriers : expansion of the use of endolysins as novel antibacterials against Gram-negative bacteria

, 2015
The emergence and spread of antibiotic-resistant bacteria drives the search for novel classes of antibiotics to replenish our armamentarium against bacterial infections.
Briers, Yves, Lavigne, Rob
core   +1 more source