Results 61 to 70 of about 172,372 (215)

Evidence That the Protein Phosphatase Activity of PTEN Contributes to Embryonic Development and Tumor Suppression

Cancer Science, EarlyView.
Mice expressing only mutant PTEN Y138L, a protein which shows normal suppression of cellular AKT yet lacks protein phosphatase activity, die in utero, and heterozygous mice display a range of tumors. This indicates both the lipid and protein phosphatase activities of PTEN work together for normal tumor suppression and embryonic development.
Priyanka Tibarewal, Laura Spinelli, Nisha Kriplani, Helen Wise, Nadege Poncet, Giulia Marzano, Karen E. Anderson, Katarzyna M. Grzes, Zofia Varyova, Mahreen Adil, C. Peter Downes, Phillip T. Hawkins, Len R. Stephens, Kate G. Storey, Doreen A. Cantrell, Bart Vanhaesebroeck, Nicholas R. Leslie   +16 more
wiley   +1 more source

Recurrent endometrial hyperplasia without atypia: how to escape the vicious circle?

, 2023
Today, endometrial hyperplasia (EH) is among the most relevant gynecological entities. Arterial hypertension, diabetes mellitus and obesity, the combination of which is referred to as metabolic syndrome, are the key risk factors of EH.
Irina A. Mullina, Mekan R. Orazov, Evgenii D. Dolgov, Viktor E. Radzinskii, Yuliia S. Artemenko, Marina B. Khamoshina   +5 more
core   +1 more source

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source

Клініко-генеалогічне дослідження хворих на гіперплазію і рак ендометрію Київського регіону

Фактори експериментальної еволюції організмів, 2017
Aim. To determine the informativeness of genealogical and morphological characteristics of patients with endometrial hyperplasia and cancer. Methods.
L. G. Buchynska, N. M. Hlushchenko, I. P. Nesina, N. P. Yurchenko   +3 more
doaj   +1 more source

A Multicellular Coordinated Network Driving Lymphovascular Space Invasion in Endometrioid Endometrial Carcinoma

Cell Proliferation, EarlyView.
Single‐cell and spatial profiling reveal that lymphovascular space invasion in endometrioid endometrial carcinoma is driven by coordinated interactions among metastatic epithelium, fibroblasts, immune cells, and endothelium. This multicellular network promotes matrix remodelling, angiogenesis, and immune evasion, forming a pro‐metastatic niche that ...
Wendi Guo, Tianxiang Liu, Runling Ren, Na Li, Wenwen Zhang, Jingwen Si, Yongjun Piao, Yuanjing Hu   +7 more
wiley   +1 more source

Expression of Cyclin D1 in Hyperplastic and Neoplastic Endometrial Lesions

Journal of Bahria University Medical and Dental College, 2017
Objective: To observe and evaluate the expression of Cyclin D1 in hyperplastic and neoplastic endometrial lesions. Methodology: This .retrospective analytical study was conducted at BMSI, JPMC over a five year period i.e.
Summayya Shawana, Saleha Masood, Zamir Ali Siddiqui   +2 more
doaj  

Atypical endometrial hyperplasia in the conception of tumor progression (literature review)

Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье
Introduction. In recent years there has been an frequency increase of endometrial hyperplasia in the structure of gynecological morbidity. Atypical endometrial hyperplasia represents important clinical relevance in the basis of progression to endometrial
M. M. Damirov, G. P. Titova, A. P. Ierusalimskiy   +2 more
doaj   +1 more source

Endometrial study by Ultrasonography and its correlation with Histopathology in Abnormal uterine bleeding

Asian Journal of Medical Sciences, 2018
Background: Abnormal Uterine Bleeding is defined as any deviation from a normal menstrual pattern. It is one of the common presentation in extremes of ages.
Pravin Shrestha
doaj   +1 more source

Concurrent and future risk of endometrial cancer in women with endometrial hyperplasia: A systematic review and meta-analysis.

PLoS ONE, 2020
BackgroundTo inform treatment decisions in women diagnosed with endometrial hyperplasia, quantification of the potential for concurrent endometrial cancer and the future risk of progression to cancer is required.MethodsWe identified studies up to ...
Michelle T Doherty, Omolara B Sanni, Helen G Coleman, Chris R Cardwell, W Glenn McCluggage, Declan Quinn, James Wylie, Úna C McMenamin   +7 more
doaj   +1 more source

Neuropsychiatric Outcomes Associated With GLP‐1 Receptor Agonist Use in Medicare Beneficiaries With Type 2 Diabetes: Variation by Treatment Pattern and Obesity Status

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Glucagon‐like peptide‐1 (GLP‐1) receptors are expressed in brain regions governing mood, reward and stress, yet the neuropsychiatric effects of GLP‐1 receptor agonist (GLP‐1 RA) therapy remain poorly characterized. We estimated associations between GLP‐1 RA use and neuropsychiatric disorders and variation by obesity status and treatment ...
Seo Hyon Baik, Fitsum Baye, Haotian Xian, Kin Wah Fung, Clement J. McDonald   +4 more
wiley   +1 more source