Results 61 to 70 of about 158,921 (215)

Differences between mitotically old and young endometrial tumors

The Journal of Pathology, EarlyView.
Abstract Human tumors likely differ in their mitotic ages, reflecting how many divisions elapse between the final tumor progenitor cell and surgical removal. We used a rapidly fluctuating CpG (fCpG) methylation clock to infer relative endometrial adenocarcinomas (EAC) mitotic ages.
Kellie Kim, Darryl Shibata
wiley   +1 more source

ALDH1 expression predicts progression of premalignant lesions to cancer in Type I endometrial carcinomas

Scientific Reports, 2021
In type 1 endometrial cancer, unopposed estrogen stimulation is thought to lead to endometrial hyperplasia which precedes malignant progression. Recent data from our group and others suggest that ALDH activity mediates stemness in endometrial cancer, but
Vei Mah, Yahya Elshimali, Alison Chu, Neda A. Moatamed, Jamar P. Uzzell, Jessica Tsui, Stephen Schettler, Hania Shakeri, Madhuri Wadehra   +8 more
doaj   +1 more source

Advent of NK3R Antagonists for the Treatment of Menopausal Hot Flushes: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT The menopause transition is marked by symptoms predominantly attributed to declining oestrogen levels. Approximately 80% of women experience associated symptoms, and 25% experience severe symptoms. The commonest are vasomotor symptoms (VMS), collectively referring to hot flushes and/or night sweats.
Aaran H. Patel, Aureliane Pierret, Edouard G. Mills, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

Telomeres and telomerase in endometrial cancer and hyperplasia

Introduction The study aimed to measure telomeres length (TL) and telomerase expression in normal endometrium and endometrial hyperplasia and cancer. Material and methods Total RNA and DNA were isolated from endometrium samples of 117 patients.
Anna Pańczyszyn, Karolina Włodarczyk, Ewa Boniewska-Bernacka, Iwona Wertel, Anna Goc   +4 more
core   +1 more source

Risk of Cancer With Hormone Replacement Therapy: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Hormone replacement therapy (HRT) remains the cornerstone of menopausal symptom management, effectively alleviating vasomotor symptoms and genitourinary syndrome, whilst mitigating long‐term risks such as osteoporosis. However, despite an increasing body of evidence on the relative safety of HRT, earlier studies that demonstrated an increased ...
Gabriella Yongue, Zachary Nash, Vikram Talaulikar, Shibani Nicum   +3 more
wiley   +1 more source

Basophils in Immunity: Activation Pathways, Roles in Allergy and AllergoOncology and Application of the Basophil Activation Test

Allergy, EarlyView.
ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan, Sofia Vlasova, Alicia Chenoweth, Debra H. Josephs, Heather J. Bax, Sophia N. Karagiannis   +5 more
wiley   +1 more source

Atypical endometrial hyperplasia in the conception of tumor progression (literature review)

Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье
Introduction. In recent years there has been an frequency increase of endometrial hyperplasia in the structure of gynecological morbidity. Atypical endometrial hyperplasia represents important clinical relevance in the basis of progression to endometrial
M. M. Damirov, G. P. Titova, A. P. Ierusalimskiy   +2 more
doaj   +1 more source

Клініко-генеалогічне дослідження хворих на гіперплазію і рак ендометрію Київського регіону

Фактори експериментальної еволюції організмів, 2017
Aim. To determine the informativeness of genealogical and morphological characteristics of patients with endometrial hyperplasia and cancer. Methods.
L. G. Buchynska, N. M. Hlushchenko, I. P. Nesina, N. P. Yurchenko   +3 more
doaj   +1 more source

Evidence That the Protein Phosphatase Activity of PTEN Contributes to Embryonic Development and Tumor Suppression

Cancer Science, EarlyView.
Mice expressing only mutant PTEN Y138L, a protein which shows normal suppression of cellular AKT yet lacks protein phosphatase activity, die in utero, and heterozygous mice display a range of tumors. This indicates both the lipid and protein phosphatase activities of PTEN work together for normal tumor suppression and embryonic development.
Priyanka Tibarewal, Laura Spinelli, Nisha Kriplani, Helen Wise, Nadege Poncet, Giulia Marzano, Karen E. Anderson, Katarzyna M. Grzes, Zofia Varyova, Mahreen Adil, C. Peter Downes, Phillip T. Hawkins, Len R. Stephens, Kate G. Storey, Doreen A. Cantrell, Bart Vanhaesebroeck, Nicholas R. Leslie   +16 more
wiley   +1 more source

Expression of Cyclin D1 in Hyperplastic and Neoplastic Endometrial Lesions

Journal of Bahria University Medical and Dental College, 2017
Objective: To observe and evaluate the expression of Cyclin D1 in hyperplastic and neoplastic endometrial lesions. Methodology: This .retrospective analytical study was conducted at BMSI, JPMC over a five year period i.e.
Summayya Shawana, Saleha Masood, Zamir Ali Siddiqui   +2 more
doaj