Results 111 to 120 of about 271,919 (259)

Endometrial Epithelial Lactate Deficiency Drives CD8+ T‐Cells Dysregulation in Unexplained Recurrent Implantation Failure

Advanced Science, Volume 13, Issue 26, 8 May 2026.
Unexplained recurrent implantation failure (RIF) represents a significant clinical challenge. Our results demonstrate that reduced lactate production in the RIF endometrium impairs the suppression of cytotoxic CD8+ T‑cells, allowing their proliferation and thereby disrupting the local immune balance essential for successful embryo implantation.
Yuanlin He, Kang Ke, Qingxia Meng, Yichun Guan, Jichun Tan, Hong Lv, Boxian Huang, Chan Tian, Qinyan Zou, Mingxing An, Yao Gao, Jingjing Chen, Xiaoyu Wei, Xi Wang, Hongxia Ma, Yuan Lin, Feiyang Diao, Yayun Gu, Zhibin Hu   +18 more
wiley   +1 more source

Loss of CDYL Results in Suppression of CTNNB1 and Decreased Endometrial Receptivity

Frontiers in Cell and Developmental Biology, 2020
Impaired endometrial receptivity is one of the major causes of recurrent implantation failure (RIF), although the underlying molecular mechanism has not been fully elucidated.
Xiaowei Zhou, Bufang Xu, Dan Zhang, Xiaoping Jiang, Hsun-Ming Chang, Peter C. K. Leung, Xiaoyu Xia, Xiaoyu Xia, Aijun Zhang, Aijun Zhang   +9 more
doaj   +1 more source

Female infertility: which role for obesity? [PDF]

, 2019
Obesity is associated with infertility in women through multiple and complex mechanisms. Briefly, the adipose tissue through the production of many factors, such as leptin, free fatty acids (FFA), and cytokines may affect both ovarian and endometrium ...
Colao, Annamaria, Gambineri, Alessandra, Laudisio, Daniela, Marocco, Chiara, Radellini, Stefano, Savastano, Silvia   +5 more
core   +1 more source

CNC–PNIPAM Drug Delivery System Improves Endometrial Receptivity via Natural Killer Cell Immune Tolerance in Endometriosis

Advanced NanoBiomed Research, Volume 6, Issue 5, May 2026.
An injectable CNC–PNIPAM hydrogel is developed for intrauterine co‐delivery of levonorgestrel and botropase. This platform reprograms uterine natural killer cells toward an immune–tolerant phenotype and enhances endometrial receptivity marker expression. The results demonstrate a promising strategy to counteract endometriosis–associated infertility and
Zhou Liang, Yingjie Wang, Chenyu Bai, Pengfei Li, Xin He, Meng Ma, Xiaoying Luo, Yi Song, Yao Li, Yun Wang   +9 more
wiley   +1 more source

Human endometrial CD98 is essential for blastocyst adhesion.

PLoS ONE, 2010
BackgroundUnderstanding the molecular basis of embryonic implantation is of great clinical and biological relevance. Little is currently known about the adhesion receptors that determine endometrial receptivity for embryonic implantation in humans ...
Francisco Domínguez, Carlos Simón, Alicia Quiñonero, Miguel Ángel Ramírez, Elena González-Muñoz, Hans Burghardt, Ana Cervero, Sebastián Martínez, Antonio Pellicer, Manuel Palacín, Francisco Sánchez-Madrid, María Yáñez-Mó   +11 more
doaj   +1 more source

Successful implantation after reducing matrix metalloproteinase activity in the uterine cavity [PDF]

, 2013
BACKGROUND: Recently, the concept of recurrent implantation failure (RIF) in assisted reproductive technology has been enlarged. Chronic uterine inflammation is a known cause of implantation failure and is associated with high matrix metalloproteinase ...
Mitsutoshi Yamada, Noboru Inagaki, Noriko Yoshii, Osamu Inoue, Rei Machiya, Takeshi Hosaka, Toshio Hamatani, Yasunori Yoshimura, Yasushi Odawara   +8 more
core   +1 more source

Investigating the Association Between Serum 25‐Hydroxyvitamin D (25(OH)D) and Body Mass Index (BMI) With In Vitro Fertilization (IVF) Outcomes Among Iranian Women: A Case‐Control Study

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Infertility affects approximately 18.3% of couples in Iran, and in vitro fertilization (IVF) remains a widely used treatment. Vitamin D deficiency and elevated body mass index (BMI) have been linked to poorer reproductive outcomes in some populations, but region‐specific evidence among Iranian women is limited.
Atefeh Asgari, Reza Mohammadi, Mohaddeseh Kalhori, Salman Khazaei, Azita Tiznobaik   +4 more
wiley   +1 more source

The Effect of Autologous Platelet Rich Plasma on Endometrial Receptivity: A Narrative Review

Medicina
Background and Objectives: Autologous platelet-rich plasma (PRP) transfusions are a relatively new treatment method used in different fields of medicine, including the field of reproductive medicine. One of the applications of these concentrated platelet
Milan Stefanović, Predrag Vukomanović, Ranko Kutlesic, Milan Trenkić, Vanja Dimitrov, Aleksa Stefanović, Vladimir Cvetanović   +6 more
doaj   +1 more source

Unveiling the Bidirectional Relationship on the Effect of Gut Microbiota and Female Infertility: A Narrative Review

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Dysbiosis is the substitution of the normal gut flora with a dysfunctional array of organisms that influences the outcome of multiple inflammatory pathways, contributing to systemic inflammation and various disease states. It has historically been understudied, with outcomes that may directly or indirectly cause pathologies.
Srijanjali Balagoni, D. Grace Evelyne, Aswathy Mathews, Rohit Rao Dugyala, Medhansh Biradar, Vodela Deekshith, Anika Goel, Amogh Verma   +7 more
wiley   +1 more source

Exploring the factors influencing the endometrial implantation window in IVF/ICSI cycles: serum AMH is correlated with endometrial receptivity

Middle East Fertility Society Journal
Objectives To Exploring the factors influencing the endometrial implantation window in IVF/ICSI cycles. Methods This study included a total of 191 women who undergone IVF/ICSI for infertility at our hospital from 2021 to 2024 and had undergone ...
Xusheng Zhao, Chunyan Ji, Lingling Liu, Yue Zhao, Wei Wang   +4 more
doaj   +1 more source