Results 51 to 60 of about 4,542,677 (277)

Transcriptomic responses to hypoxia in endometrial and decidual stromal cells [PDF]

Reproduction, 2019
Abstract Human reproductive success depends on a properly decidualized uterine endometrium that allows implantation and the formation of the placenta. At the core of the decidualization process are endometrial stromal fibroblasts (ESF) that differentiate to decidual stromal cells (DSC).
Rytkönen, Kalle T., Heinosalo, Taija, Mahmoudian, Mehrad, Ma, Xinghong, Perheentupa, Antti, Elo, Laura L., Poutanen, Matti, Wagner, Günter P.   +7 more
openaire   +4 more sources

An IGF1-expressing endometrial stromal cell population is associated with human decidualization

BMC Biology, 2022
Background Decidualization refers to the process of transformation of endometrial stromal fibroblast cells into specialized decidual stromal cells that provide a nutritive and immunoprivileged matrix essential for blastocyst implantation and placental ...
Jia-Wei Shi, Zhen-Zhen Lai, Hui-Li Yang, Wen-Jie Zhou, Xiao-Ya Zhao, Feng Xie, Song-Ping Liu, Wei-Dong Chen, Tao Zhang, Jiang-Feng Ye, Xiang-Yu Zhou, Ming-Qing Li   +11 more
doaj   +1 more source

Activated platelets induce hypoxia-inducible factor-1α expression likely through transforming growth factor-β1 in human endometrial stromal cells

Reproductive and Developmental Medicine, 2019
Objective: Endometriosis is a common gynecological disease with an enigmatic pathogenesis. Recent studies suggest that the behavior of normal endometrial stromal cells can dramatically change under hypoxic conditions, which effectively turns them into ...
Qiu-Ming Qi, Sun-Wei Guo, Xi-Shi Liu
doaj   +1 more source

Thrombin-induced chemokine production in endometrial stromal cells [PDF]

Human Reproduction, 2010
In order to investigate the regulation of chemokines [interleukin-8 (IL-8), growth-regulated oncogene (GRO)α, monocyte chemoattractant protein-1 (MCP-1)) induced by thrombin in endometrial stromal cells (ESCs), the effects of thrombin, a protease activated receptor (PAR)-1 antagonist (PPACK), mitogen-activated protein kinase kinase inhibitor (U0126 ...
Yasushi, Kawano, Yuichi, Furukawa, Yukie, Kawano, Kaei, Nasu, Hisashi, Narahara   +4 more
openaire   +2 more sources

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Mesenchymal Differentiation and Organ Distribution of Established Human Stromal Cell Lines in NOD/SCID Mice [PDF]

, 2001
Two human stromal cell lines were established previously from bone marrow-derived primary long-term cultures by immortalization using the SV40 large T antigen and cellular cloning. After irradiation, the fibroblast-like cell lines L87/4 and L88/5 support
Thalmeier, Karin, Moosmann, Sabine, Wiest, Irmgard, Huss, Ralf, Meissner, Petra, Sagebiel, Sabine, Thalmeier, Karin;Meissner, Petra;Moosmann, Sabine;Sagebiel, Sabine;Wiest, Irmgard;Huss, Ralf   +6 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Microfluidic chip-integrated vascularized endometrial complexes: Mitochondrial function and paracrine crosstalk enhance regenerative potential

Bioactive Materials
Endometrial injury is a prevalent gynecological condition that poses a significant threat to fertility and women's health. While the current reported endometrial organoids demonstrate potential in remodeling endometrial functions, they often lack the ...
Yongdong Dai, Fanxuan Zhao, Qiuli Chen, Biya Zeng, Weijia Gu, Yi Zhang, Fangying Sun, Xinyu Wang, Xiang Lin, Na Liu, Yulu Wang, Feng Zhou, Jianhua Yang, Shangjing Xin, Ye Feng, Songying Zhang   +15 more
doaj   +1 more source

MicroRNA-342 Promotes the Malignant-Like Phenotype of Endometrial Stromal Cells via Regulation of Annexin A2

Analytical Cellular Pathology, 2021
The relevance of miRNA- (miR-) 342 to endometriosis has been highlighted, while its function in regulating the malignant-like phenotype of endometrial stromal cells which demonstrate epigenetic abnormalities that alter expression of transcription factors,
Dan Sun, Yiting Wang, Li Wang, Xin Guo
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source