Biochemical characterization and X-ray structural and mutagenic analyses of the putative autolysin CdCwlT33800 catalytic domain from Clostridioides difficile [PDF]
Applied and Environmental MicrobiologyClostridioides difficile is a major pathogen of pseudomembranous colitis, and new antimicrobial agents are needed for its treatment. Autolysins are peptidoglycan-degrading enzymes that generally reorganize the cell wall during cell division but kill ...
Hiroshi Sekiya +3 more
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Contribution of UbrA, a ubiquitin ligase essential for Arg/N-degron pathway, to peptidase gene expression in Aspergillus oryzae [PDF]
Applied and Environmental MicrobiologyThe degradation of intracellular proteins by N-degron pathways depends on their N-terminal amino acids. In budding yeast, the Arg/N-degron pathway controls the expression of dipeptide/tripeptide transporter gene by degrading a transcriptional repressor ...
Waka Muromachi +4 more
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Comparative Transcriptome Analysis Reveals Expression of Defense Pathways and Specific Protease Inhibitor Genes in Solanum lycopersicum in Response to Feeding by Tuta absoluta [PDF]
InsectsUnderstanding plant-insect interactions can help control the harm of herbivorous pests. According to transcriptome data, transcripts of Solanum lycopersicum responding to feeding by Tuta absoluta were screened for important endopeptidase inhibitors ...
Yan Zhou +4 more
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Discovery and biochemical characterization of the D-aspartyl endopeptidase activity of the serine protease LACTB. [PDF]
J Biol ChemIto G, Utsunomiya-Tate N.
europepmc +2 more sources
Molecules, 2021 The Angiotensin-I-converting enzyme (ACE) is a peptidase with a significant role in the regulation of blood pressure. Within this work, a systematic review on the enzymatic preparation of Angiotensin-I-Converting Enzyme inhibitory (ACEi) peptides is ...
Azis Boing Sitanggang +5 more
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Functional Analysis of the Endopeptidase and Holin From Planktothrix agardhii Cyanophage PaV-LD
Frontiers in Microbiology, 2022 A cyanophage PaV-LD, previously isolated from harmful filamentous cyanobacterium Planktothrix agardhii, was sequenced, and co-expression of its two ORFs in tandem, ORF123 and ORF124, inhibited growth on the model cyanobacterium Synechocystis sp.
Li-Hui Meng +5 more
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Animal Models and Experimental Medicine, 2023 β‐Amyloid (Aβ) is a specific pathological hallmark of Alzheimer's disease (AD). Because of its neurotoxicity, AD patients exhibit multiple brain dysfunctions.
Haolin Zhang +5 more
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Frontiers in Nutrition, 2023 This study investigated the hydrolysis effect of the endopeptidase from wheat malt on the soybean meal proteins. The results indicated that the endopeptidase broke the peptide bonds of soybean meal proteins and converted the alcohol- and alkali-soluble ...
Jingxiao Fan +3 more
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mBio, 2021 During evolution, enzymes can undergo shifts in preferred substrates or in catalytic activities. An intriguing question is how enzyme function changes following horizontal gene transfer, especially for bacterial genes that have moved to animal genomes ...
Thomas E. Smith +5 more
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Evaluation of Enkephalin-Degrading Enzymes in Sperm from Heroin-Addicted Men [PDF]
International Journal of Fertility and Sterility, 2020 Background The aim of this study was to investigate two enkephalin-degrading enzymes, aminopeptidase N (APN/ CD13) and endopeptidase (NEP/CD10), gene and protein expression levels in sperm samples of fertile and heroin- addicted men, and the ...
Samira Rezaei-Mojaz +9 more
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