Results 1 to 10 of about 82,731 (288)

Comparative Transcriptome Analysis Reveals Expression of Defense Pathways and Specific Protease Inhibitor Genes in Solanum lycopersicum in Response to Feeding by Tuta absoluta [PDF]

Insects
Understanding plant-insect interactions can help control the harm of herbivorous pests. According to transcriptome data, transcripts of Solanum lycopersicum responding to feeding by Tuta absoluta were screened for important endopeptidase inhibitors ...
Yan Zhou, Yongyi Pan, Jia Liu, Wenjia Yang, Guangmao Shen   +4 more
doaj   +2 more sources

Endopeptidase-mediated beta lactam tolerance. [PDF]

PLoS Pathogens, 2015
In many bacteria, inhibition of cell wall synthesis leads to cell death and lysis. The pathways and enzymes that mediate cell lysis after exposure to cell wall-acting antibiotics (e.g.
Tobias Dörr, Brigid M Davis, Matthew K Waldor   +2 more
doaj   +2 more sources

Computer-aided lead optimization: improved small-molecule inhibitor of the zinc endopeptidase of botulinum neurotoxin serotype A. [PDF]

PLoS ONE, 2007
Optimization of a serotype-selective, small-molecule inhibitor of botulinum neurotoxin serotype A (BoNTA) endopeptidase is a formidable challenge because the enzyme-substrate interface is unusually large and the endopeptidase itself is a large, zinc ...
Jing Tang, Jewn Giew Park, Charles B Millard, James J Schmidt, Yuan-Ping Pang   +4 more
doaj   +5 more sources

Endopeptidase-24.5 is not a metallo-endopeptidase [PDF]

Biochemical Journal, 1987
Judith Bond, P. Elaine Butler
openalex   +4 more sources

Alzheimer-associated cerebrospinal fluid fragments of neurogranin are generated by Calpain-1 and prolyl endopeptidase

Molecular Neurodegeneration, 2018
Background Neurogranin (Ng) is a small 7.6 kDa postsynaptic protein that has been detected at elevated concentrations in cerebrospinal fluid (CSF) of patients with Alzheimer’s disease (AD), both as a full-length molecule and as fragments from its C ...
Bruno Becker, Faisal Hayat Nazir, Gunnar Brinkmalm, Elena Camporesi, Hlin Kvartsberg, Erik Portelius, Martina Boström, Marie Kalm, Kina Höglund, Maria Olsson, Henrik Zetterberg, Kaj Blennow   +11 more
doaj   +2 more sources

Isolation of a nanomolar scFv inhibiting the endopeptidase activity of botulinum toxin A, by single-round panning of an immune phage-displayed library of macaque origin

BMC Biotechnology, 2011
Background Botulinum neurotoxin A (BoNT/A), mainly represented by subtype A1, is the most toxic substance known. It causes naturally-occurring food poisoning, and is among the biological agents at the highest risk of being weaponized.
Chahboun Siham, Hust Michael, Liu Yvonne, Pelat Thibaut, Miethe Sebastian, Helmsing Saskia, Jones Russell GA, Sesardic Dorothea, Thullier Philippe   +8 more
doaj   +2 more sources

RNA-activated protein cleavage with a CRISPR-associated endopeptidase

Science, 2022
In prokaryotes, CRISPR-Cas systems provide adaptive immune responses against foreign genetic elements through RNA-guided nuclease activity. Recently, additional genes with non-nuclease functions have been found in genetic association with CRISPR systems,
Jonathan Strecker, F. E. Demircioglu, David Li, Guilhem Faure, M. E. Wilkinson, J. Gootenberg, Omar O. Abudayyeh, H. Nishimasu, Rhiannon K. Macrae, Feng Zhang   +9 more
semanticscholar   +1 more source

Cathepsin B Dipeptidyl Carboxypeptidase and Endopeptidase Activities Demonstrated across a Broad pH Range

Biochemistry, 2022
Cathepsin B is a lysosomal protease that participates in protein degradation. However, cathepsin B is also active under neutral pH conditions of the cytosol, nuclei, and extracellular locations.
Michael C Yoon, V. Hook, A. O’Donoghue
semanticscholar   +1 more source

The Mechanism of Asparagine Endopeptidase in the Progression of Malignant Tumors: A Review

Cells, 2021
Asparagine endopeptidase (AEP), also called legumain, is currently the only known cysteine protease that specifically cleaves peptide bonds in asparaginyl residue in the mammalian genome.
Wenrui Zhang, Yingying Lin
semanticscholar   +1 more source

Functional Analysis of the Endopeptidase and Holin From Planktothrix agardhii Cyanophage PaV-LD

Frontiers in Microbiology, 2022
A cyanophage PaV-LD, previously isolated from harmful filamentous cyanobacterium Planktothrix agardhii, was sequenced, and co-expression of its two ORFs in tandem, ORF123 and ORF124, inhibited growth on the model cyanobacterium Synechocystis sp.
Li-Hui Meng, Li-Hui Meng, Fei Ke, Qi-Ya Zhang, Qi-Ya Zhang, Zhe Zhao   +5 more
doaj   +1 more source