Results 91 to 100 of about 154,667 (281)
Scientific Reports, 2020 The peptidoglycan layer is responsible for maintaining bacterial cell shape and permitting cell division. Cell wall growth is facilitated by peptidoglycan synthases and hydrolases and is potentially modulated by components of the central carbon ...
Jad Sassine +4 more
doaj +1 more source
Endopeptidase-24.5 is not a metallo-endopeptidase [PDF]
Biochemical Journal, 1987 J S, Bond, P E, Butler
openaire +2 more sources
The loops facing the active site of prolyl oligopeptidase are crucial components in substrate gating and specificity [PDF]
, 2013 Prolyl oligopeptidase (POP) has emerged as a drug target for neurological diseases. A flexible loop structure comprising loop A (res. 189–209) and loop B (res. 577–608) at the domain interface is implicated in substrate entry to the active site.
Juliano, Luiz +10 more
core +1 more source
Mammalian Osteoderm Ultrastructure in the Armored Acomys Spiny Mouse Tail
Small, EarlyView.The ultrastructure of armored platelets – termed osteoderms – in the tail skin of Acomys cahirinus spiny mice is characterized using 2D and 3D microscopy methods. The imbricated structure is composed of calcium phosphate biomineral and has select structural elements that are bone‐like and tooth‐like in nature.
Joseph Deering +2 more
wiley +1 more source
Characterization of Legumain Degradome Confirms Narrow Cleavage Specificity
Acta Chimica Slovenica, 2019 Legumain or asparagine endopeptidase is a unique cysteine endopeptidase with a distinctive specificity for the hydrolysis of peptide bonds after asparagine and to a lesser extent after aspartate.
Robert Vidmar +4 more
doaj +1 more source
Birnavirus VP4 Processing Endopeptidase
, 2013 The third edition of the Handbook of Proteolytic Enzymes aims to be a comprehensive reference work for the enzymes that cleave proteins and peptides, and contains over 800 chapters. Each chapter is organized into sections describing the name and history,
Delmas, Bernard
core +1 more source
Broadening the View: Substance P and Its Metabolism in Pruritus‐Related Diseases
The Journal of Dermatology, EarlyView.ABSTRACT Chronic pruritus is a debilitating symptom accompanying numerous inflammatory skin diseases and remains a major therapeutic challenge. Neurogenic inflammation plays a central role in its pathogenesis, with the tachykinin substance P acting as a key mediator at the interface of the nervous system, immune cells, and cutaneous tissues.
Thomas Walter, Bjoern B. Burckhardt
wiley +1 more source
Neutral Endopeptidase Activity is Increased in the Skin of Subjects with Diabetic Ulcers
, 2002 Cutaneous sensory nerves mediate inflammation and wound healing by releasing neuropeptides, such as substance P, which stimulates pro-inflammatory responses by keratinocytes, fibroblasts, and endothelial cells.
Antezana, Marcos A. +8 more
core +1 more source
Identification of drug repurposing candidates for the treatment of polycystic kidney disease
British Journal of Pharmacology, EarlyView.Background and Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end‐stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective treatments. Experimental Approach We identified birinapant, bardoxolone methyl and salicylic acid as repurposing candidates for ADPKD and
Alina Meyer +9 more
wiley +1 more source
The expression of Bacillus intermedius glutamyl endopeptidase gene in Bacillus subtilis recombinant strains [PDF]
, 2007 The gene encoding for B. intermedius glutamyl endopeptidase (gseBi) has previously been cloned and its nucleotide sequence analyzed. In this study, the expression of this gene was explored in protease-deficient strain B.
Shagimardanova E. +8 more
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