Results 101 to 110 of about 154,667 (281)

Diagnosis and management of equine metabolic syndrome

open access: yesEquine Veterinary Education, EarlyView.
Summary Equine metabolic syndrome (EMS) is a prevalent endocrine disorder that increases the risk of hyperinsulinaemia‐associated laminitis (HAL), the most common and clinically significant form of laminitis. The central pathological feature of EMS is insulin dysregulation (ID), which encompasses basal or postprandial hyperinsulinaemia and tissue ...
F. R. Bertin
wiley   +1 more source

A new brain metalloendopeptidase which degrades the Alzheimer ß-amyloid 1-40 peptide producing soluble fragments without neurotoxic effects

open access: yesBrazilian Journal of Medical and Biological Research, 1997
A new metalloendopeptidase was purified to apparent homogeneity from a homogenate of normal human brain using successive steps of chromatography on DEAE-Trisacryl, hydroxylapatite and Sephacryl S-200.
K.M. Carvalho   +3 more
doaj   +1 more source

Genes associated with endopeptidase inhibitor activity up-regulated in ASG.

open access: yes, 2015
Genes associated with endopeptidase inhibitor activity up-regulated in ASG.
Yuqian Wu (549440)   +7 more
core   +1 more source

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

open access: yesThe FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Optimization of Bacillus intermedius glutamyl endopeptidase production by recombinant strain of Bacillus subtilis and localization of glutamyl endopeptidase in Bacillus subtilis cells

open access: yes, 2020
The biosynthesis of glutamyl endopeptidase from Bacillus intermedius 3-19 in recombinant strain of Bacillus subtilis has been investigated. The composition of culture medium, which yielded the maximum glutamyl endopeptidase production by B.
Kostrov S.   +6 more
core  

Specificity comparison of a serine endopeptidase (SH1) and a serine thiol endopeptidase (STH2) purified from human urine

open access: yes, 2004
In this study, we compared the properties of a serine endopeptidase H1 (SH1) and a serine thiol endopeptidase (STH2) purified from human urine by DEAE-cellulose followed by a Bio Gel A(0.5 m) or Sepharose Mercurial chromatographs. These enzymes differ in
Casarini, D. E.   +5 more
core   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

open access: yesThe FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou   +4 more
wiley   +1 more source

POTENT INHIBITION OF ENDOPEPTIDASE 24.16 AND ENDOPEPTIDASE 24.15 BY THE PHOSPHONAMIDE PEPTIDE N-(PHENYLETHYLPHOSPHONYL)-GLY-L-PRO-L-AMINOHEXANOIC ACID

open access: yes, 1992
A phosphonamide peptide, N-(phenylethylphosphonyl)-Gly-L-Pro-L-aminohexanoic acid, previously shown to block Clostridium histolyticum collagenases, was examined as a putative inhibitor of endopeptidase 24.16 and endopeptidase 24.15.
CHECLER, F   +4 more
core  

ポルフィロモナス・ジンジパリスにおける9型分泌機構依存性分泌ペプチダーゼ、リシン特異的セリンエンドペプチダーゼの解析

open access: yes, 2014
Porphyromonas gingivalis, a significant causative agent of adult periodontitis, possesses a novel secretion system called the type IX secretion system (T9SS).
野中, 美那子
core   +1 more source

Interactions between small leucine‐rich proteoglycans and proteases: implications for tissue homeostasis and pathology

open access: yesThe FEBS Journal, EarlyView.
Small leucine‐rich proteoglycans (SLRPs) are key modulators of extracellular matrix structure and signaling. Their proteolytic processing by MMPs (Matrix Metalloproteinases), ADAMTS (disintegrin and metalloprotease with thrombospondin motifs), and serine proteases generates bioactive fragments that regulate collagen remodeling, inflammation, and ...
Maria Konstantaraki   +4 more
wiley   +1 more source

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