The FEBS Journal, EarlyView.Basement membrane (BM) homeostasis relies on a balance between integrity, controlled remodelling and pathological degradation. Increased protease expression beneath the BM, along with reduced levels of endogenous protease inhibitors, drives the transition from a continuous, protective barrier to a discontinuous interface.
Clara Legendre +2 more
wiley +1 more source
A Targeted Therapeutic Rescues Botulinum Toxin-A Poisoned Neurons
, 2008 Botulinum neurotoxin (BoNT), a Category A biothreat agent, is the most potent poison known to mankind. Currently no antidote is available to rescue poisoned synapses.
Radharaman Ray +6 more
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Cloning, isolation, and characterization of mammalian legumain, an asparaginyl endopeptidase
, 1997 Legumain is a cysteine endopeptidase that shows strict specificity for hydrolysis of asparaginyl bonds. The enzyme belongs to peptidase family C13, and is thus unrelated to the better known cysteine peptidases of the papain family, C1 (Rawlings, N.
Hewitt, Eric +8 more
core +1 more source
Malaria mosquito antimicrobial defence requires immunity and detoxification gene regulation by Lola
Insect Molecular Biology, EarlyView.Malaria mosquito antimicrobial defence requires upregulation of lola. Attenuation of lola in the midgut of Anopheles albimanus mosquitoes inhibits the upregulation of immunity genes induced by challenge. Putative target genes of the Lola transcription factor were revealed by lola attenuation, including Cecropin‐C, Draper, PPAF2, Clip‐domain serine ...
Heidi Espadas‐Álvarez +1 more
wiley +1 more source
Ocular Manifestations of Infectious Salmon Anaemia Virus Infection in Atlantic Salmon (Salmo salar)
Journal of Fish Diseases, EarlyView.ABSTRACT Eyes are essential sensory organs needed by teleost Atlantic salmon for high visual acuity and survival in both the wild and in aquaculture settings. In this work, we assessed the ocular manifestations of Infectious Salmon Anaemia Virus (ISAV) infection in Atlantic salmon by a cohabitation‐mediated infection assay and histological and ...
Emily Mahon +12 more
wiley +1 more source
Novel M23 peptidases Pgp4, Pgp5, and Pgp6 contribute to helical cell shape in Campylobacter jejuni
Frontiers in MicrobiologyThe helical morphology of Campylobacter jejuni is maintained by its peptidoglycan (PG) layer and influences its success as a pathogen. Periplasmic PG hydrolases that cleave the PG glycan backbone and peptide sidechains (such as carboxypeptidases and ...
Chang Sheng-Huei Lin +6 more
doaj +1 more source
Optimized medium for the efficient production of bacillus intermedium glutamyl endopeptidase by the recombinant bacillus subtilis [PDF]
, 2000 A nutrient medium was elaborated for the efficient production of glutamyl endopeptidase by the recombinant Bacillus subtilis strain AJ73 bearing the Bacillus intermedius 3-19 glutamyl endopeptidase gene within a multicopy plasmid.
Balaban N. +4 more
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Use of an Asparaginyl Endopeptidase for Chemo-enzymatic Peptide and Protein Labeling
, 2020 Transpeptidases are ideal biocatalysts for site-specific peptide and protein labeling, whereas reactions that target N-terminus cysteine with commercially available reagents have become common practice.
Simon, Tang +5 more
core +1 more source
Nanoparticles in Periodontology and Implant Dentistry: From Mechanisms to Clinical Applications
Journal of Periodontal Research, EarlyView.Nanotechnology holds significant promise in improving dental care, yet there is a need for more reliable clinical studies to validate its effectiveness and safety. ABSTRACT Recent advances in nanotechnology are reshaping the landscape of periodontology and implant dentistry, particularly through the application of nanoparticles (NPs).
Chun Xu +4 more
wiley +1 more source
Purification and Characterisation of Endopeptidase Produced by Lactococcus Lactis Subsp. Lactis RI 11 [PDF]
, 2001 In the this study, 10 isolates of Lactic Acid Bacteria (LAB) were isolated from ikan rebus (steam fish) purchased from a local market, was characterised by phenotypical and biochemical characteristics.
Woo, Kwan Kit
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