Results 141 to 150 of about 154,667 (281)

STRUCTURAL REQUIREMENTS of BIOACTIVE PEPTIDES for INTERACTION WITH ENDOPEPTIDASE-22.19

, 1994
A series of biologically active peptides and related compounds (opioid peptides, neurotensin, and bradykinin) were used as substrates or competitive inhibitors to study the structural requirements for peptide interaction with endopeptidase 22.19.
Ribeiro, MJF, Ferro, E. S., Suzuki, K., Toffoletto, O., Sasaki, Y., Gomes, M. D., Juliano, L., Camargo, ACM, Fernandes, B. L.   +8 more
core   +1 more source

Placental mitochondrial metabolic adaptation maintains cellular energy balance in pregnancy complicated by gestational hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Placental mitochondrial adaptation to gestational hypoxia. Hypoxic pregnancy in sheep increases placental insulin like growth factor 2 (IGF2) signalling (1), which is associated with a shift in capacity away from β‐oxidation (2) and complex I‐mediated respiration (3), while maintaining total oxidative phosphorylation capacity (4).
Wen Tong, Beth J. Allison, Kirsty L. Brain, Olga V. Patey, Youguo Niu, Kimberley J. Botting, Sage G. Ford, Tess A. Garrud, Peter F. B. Wooding, Qiang Lyu, Lin Zhang, Jin Ma, Alice P. Sowton, Katie A. O'Brien, Tereza Cindrova‐Davies, Hong Wa Yung, Graham J. Burton, Andrew J. Murray, Dino A. Giussani   +18 more
wiley   +1 more source

Effects of endopeptidase inhibitors on rSeCP.

, 2015
* PMSF, phenylmethylsulfonyl fluoride; AEBSF, 4-(2-Aminoethyl) benzenesulfonyl fluoride; EDTA, ethylenediaminetet-raacetate; E-64, L-trans-epoxysuccinyl-leucylamide (4-guanidino) butane.
Xin Qi (177590), Xi Zhang (83736), Jing Cui (28824), Ruo Dan Liu (340776), Zi Fang Zhang (750088), Peng Jiang (16544), Li Na Liu (707222), Zhong Quan Wang (340774)   +7 more
core   +1 more source

Genomic Analysis of Inbreeding Depression on Productive Traits in Rubia Galega Beef Cattle Breed

Journal of Animal Breeding and Genetics, Volume 143, Issue 4, Page 508-523, July 2026.
ABSTRACT In autochthonous livestock breeds with small populations, such as the Rubia Galega from Galicia (Spain), mating between relatives is common and can lead to inbreeding depression. Genomic inbreeding coefficients were estimated for 4984 animals using ~63,000 SNPs to assess inbreeding depression in four key traits: age at first calving (AFC) with
N. Mejuto‐Vázquez, C. Hervás‐Rivero, R. Rodríguez‐Bermúdez, D. López‐Carbonell, M. Hermida, P. Martínez, L. Varona   +6 more
wiley   +1 more source

A stage‐dependent seed defense response to explain efficient seed transmission of Xanthomonas citri pv. fuscans to common bean

Plant, Cell &Environment, Volume 49, Issue 7, Page 3500-3517, July 2026.
Abstract Although seed represents an important means of plant pathogen dispersion, the seed–pathogen dialogue remains largely unexplored. A multiomic approach was performed at different seed developmental stages of common bean (Phaseolus vulgaris L.) during asymptomatic colonization by Xanthomonas citri pv.
Armelle Darrasse, Łukasz Paweł Tarkowski, Martial Briand, David Lalanne, Nicolas W. G. Chen, Matthieu Barret, Jerome Verdier   +6 more
wiley   +1 more source

from the Faculty of Medicine 1331

, 2007
Karlsson, K., 2004, Substance P Endopeptidase; Purification and Characterization of Enzyme Activity and Evaluation of its Function during Stressful Condition, Acta Universitatis Upsaliensis, Comprehensive Summaries of Uppsala Dissertations from the ...
Substance P Endopeptidase, Purification And Characterizataion, Krister Karlsson   +2 more
core  

Racemisation of Amino Acids: From Synthetic Challenge to Biological Significance

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Racemisation, once considered an undesirable synthetic side reaction, also occurs naturally in amino acids and influences biological processes. Evidence links stereochemical conversion to ageing, protein turnover, and cellular development. This review examines mechanisms, control strategies in synthesis, applications and implications in physiology ...
Othman Al Musaimi
wiley   +1 more source

Optimized medium for the efficient production of bacillus intermedium glutamyl endopeptidase by the recombinant bacillus subtilis

, 2020
A nutrient medium was elaborated for the efficient production of glutamyl endopeptidase by the recombinant Bacillus subtilis strain AJ73 bearing the Bacillus intermedius 3-19 glutamyl endopeptidase gene within a multicopy plasmid.
Balaban N., Gabdrakhmanova L., Shakirov E., Sharipova M., Rudenskaya G.   +4 more
core  

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, Volume 13, Issue 33, 15 June 2026.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

A liver metalloendopeptidase which degrades the circulating hypotensive peptide hormones bradykinin and atrial natriuretic peptide

Brazilian Journal of Medical and Biological Research, 1999
A new metalloendopeptidase was purified to apparent homogeneity from a homogenate of normal human liver using successive steps of chromatography on DEAE-cellulose, hydroxyapatite and Sephacryl S-200.
Carvalho K.M., Nava R.A., França M.S.F., Medeiros M.A.S., Camarão G.C., Juliano L.   +5 more
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