Results 101 to 110 of about 83,074 (351)

Redirecting the Peptide Cleavage Causes Protease Inactivation

Angewandte Chemie International Edition, Accepted Article.
Cysteine and serine proteases cleave peptides through covalent catalysis by generating a transient adduct with the N‐terminal part of the substrate after releasing its C‐terminal part. We demonstrate the unique redirection of this event leading to strong enzyme inactivation.
Michael Gütschow, Christian Breuer, Jim Küppers, Anna-Christina Schulz-Fincke, Anna Heilos, Carina Lemke, Petra Spiwokowá, Janina Schmitz, Laura Cremer, Marta Frigolé-Vivas, Michael Lülsdorff, Matthias D. Mertens, Filip Wichterle, Miloš Apeltauer, Martin Horn, Erik Gilberg, Norbert Furtmann, Jürgen Bajorath, Ulrike Bartz, Bernd Engels, Michael Mareš   +20 more
wiley   +1 more source

Seprase: An overview of an important matrix serine protease [PDF]

, 2008
Seprase or Fibroblast Activation Protein (FAP) is an integral membrane serine peptidase, which has been shown to have gelatinase activity. Seprase has a dual function in tumour progression.
Abbott, Abbott, Abbott, Acharya, Adams, Adams, Aertgeerts, Aimes, Alcolado, Aoyama, Ariga, Artym, Bangert, Barrett, Bauvois, Bermpohl, Birney, Bissell, Brendan F. O'Connor, Brown, Busek, Chen, Chen, Chen, Chen, Cheng, Cheng, Christiansen, Collins, Corpet, De Wever, Del Rosso, Dolznig, Dvorak, Edosada, Edosada, Fassnacht, Fidler, Fink, Flentke, Fulop, Garcia-Horsman, Garin-Chesa, Gerner, Ghersi, Ghersi, Ghersi, Gilmore, Goldstein, Goldstein, Goodman, Gorrell, Guex, Hofheinz, Huang, Huber, Huber, Ibrahim, Iwasa, Jin, Kelly, Kelly, Kelly, Kelly, Kloft, Koyama, Lee, Lee, Lee, Lee, Lee, Levy, Levy, Levy, Loeffler, Mathew, Mersmann, Milner, Monsky, Mori, Mueller, Nicholas, Niedermeyer, Niedermeyer, Niedermeyer, Oertel, Okada, Okada, Ollis, Pamela O'Brien, Park, Pineiro-Sanchez, Ramirez-Montagut, Rennex, Rettig, Rettig, Rettig, Rettig, Rosenblum, Samel, Scanlan, Schechter, Scott, Scott, Sieweke, Skubitz, Stremenova, Sun, Tahtis, Tran, Wang, Wang, Welt, Welt, Wesley, Zhang   +115 more
core   +1 more source

Evaluation of NaTto Red Yeast Rice on Regulating Blood Lipid (ENTRY) Study: A Multicenter, Double‐Placebo, Double‐Blinded, Randomized Controlled Trial in Chinese Adults

Chronic Diseases and Translational Medicine, EarlyView.
Study flow chart of the ENTRY study. ABSTRACT Background Statins are the first line of treatment for dyslipidemia, but their side effects often reduce medication compliance. Natto and red yeast rice are natural ingredients with lipid‐lowering effects.
Shufeng Chen, Fangchao Liu, Jinyue Li, Fengchao Liang, Jianxin Li, Jie Cao, Donghua Liu, Keyong Huang, Hongfan Li, Xiangfeng Lu, Jianfeng Huang, Dongfeng Gu   +11 more
wiley   +1 more source

Deferasirox Derivatives as Inhibitors of Kallikrein‐Related Peptidases Associated to Neurodegenerative Diseases

ChemMedChem, EarlyView.
Dysregulated proteolysis mediated by kallikrein‐related peptidases (KLKs) and iron overload are involved in the progression of neurodegenerative diseases. Deferasirox, an clinically‐approved iron chelator, and its newly synthesized derivatives have been identified as inhibitors of major central nervous system KLKs with low cytotoxicity and effective ...
Rilès Boumali, Elodie David, Nancy Chaaya, Morane Lucas, Sabrina Aït Amiri, Valérie Lefort, Anthony Nina‐Diogo, Michèle Salmain, Isabelle Petropoulos, Vincent Corcé, Chahrazade El Amri, Candice Botuha   +11 more
wiley   +1 more source

Amino acid composition of enzymatically hydrolysed potato protein preparations

Czech Journal of Food Sciences, 2014
We determine the effects of the technology of obtaining potato protein preparation and of different variants of enzymatic hydrolysis on the chemical and amino acid compositions of the hydrolysates obtained.
Anna Pęksa, Joanna MiedziankA
doaj   +1 more source

Crystal structure of the human PRPK–TPRKB complex

Communications Biology, 2021
Jian Li and Xinli Ma et al. present a 2.53 Å crystal structure of a complex consisting of the human p53-related protein kinase (PRPK), TP53RK-binding protein, and adenylyl-imidodiphosphate.
Jian Li, Xinli Ma, Surajit Banerjee, Hanyong Chen, Weiya Ma, Ann M. Bode, Zigang Dong   +6 more
doaj   +1 more source

Family C1 cysteine proteases: Biological diversity or redundancy? [PDF]

, 2003
Recent progress in the identification and partial characterization of novel genes encoding cysteine proteases of the papain family has considerably increased our knowledge of this family of enzymes.
Brömme D., Coulombe R., Musil D., Navab R., Tepel C.   +4 more
core   +1 more source

Ruthenium Nanozyme@Magnesium silicate nanosheets encapsuled in microneedle patches promote repair of radiation‐induced skin defects by remodeling pathological environment

Interdisciplinary Medicine, EarlyView.
In this work, we introduce a novel composite microneedle (MN) patch that integrates ruthenium‐loaded magnesium silicate nanosheets (MSR) as a multifaceted therapeutic platform with oxidative stress mitigation, ROS generation inhibition and cellular signaling pathways restoration for treating RISD.
Zhongyi Sun, Haibo Liu, Mengting Yin, Ningning Cheng, Wencheng Liu, Kangkang Zhao, Hua Zeng, Xuming Chen, Zijie Wang, Xuhui Zhou, Xinyu Zhao, Feng Chen   +11 more
wiley   +1 more source

Cell morphology maintenance in Bacillus subtilis through balanced peptidoglycan synthesis and hydrolysis

Scientific Reports, 2020
The peptidoglycan layer is responsible for maintaining bacterial cell shape and permitting cell division. Cell wall growth is facilitated by peptidoglycan synthases and hydrolases and is potentially modulated by components of the central carbon ...
Jad Sassine, Joana Sousa, Michael Lalk, Richard A. Daniel, Waldemar Vollmer   +4 more
doaj   +1 more source

Pharmaceutically modified subtilisins withstand acidic conditions and effectively degrade gluten in vivo [PDF]

, 2019
Detoxification of gluten immunogenic epitopes is a promising strategy for the treatment of celiac disease. Our previous studies have shown that these epitopes can be degraded in vitro by subtilisin enzymes derived from Rothia mucilaginosa, a natural ...
Darwish, Ghassan, Helmerhorst, Eva J., Oppenheim, Frank G., Schuppan, Detlef, Wei, Guoxian   +4 more
core   +1 more source