A new metabolic path in type 3 rickets
The FEBS Journal, EarlyView.Rickets, a bone disorder, was historically categorised into either nutritional (vitamin D deficiency) or genetic forms involving loss‐of‐function mutations in mineral metabolism. Recently, a new mechanism, type 3 rickets, was discovered to be caused by a gain‐of‐function mutation in CYP3A4 (Ile301Thr).
Toshiya Senda, Yoshihisa Hirota
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Purification and biochemical characterization of a vacuolar serine endopeptidase induced by glucose starvation in maize roots [PDF]
, 1996 Franck JAMES +4 more
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A genomic approach to the study of Tribolium castaneum genetics, development & evolution [PDF]
, 2004 During the last decade, Tribolium castaneum has become the insect of choice for comparative genetics and developmental studies outside of drosophilids. Until recently, most molecular studies have focused on the comparative analysis of early development ...
Savard, Joël
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Genomic Analysis of Inbreeding Depression on Productive Traits in Rubia Galega Beef Cattle Breed
Journal of Animal Breeding and Genetics, EarlyView.ABSTRACT In autochthonous livestock breeds with small populations, such as the Rubia Galega from Galicia (Spain), mating between relatives is common and can lead to inbreeding depression. Genomic inbreeding coefficients were estimated for 4984 animals using ~63,000 SNPs to assess inbreeding depression in four key traits: age at first calving (AFC) with
N. Mejuto‐Vázquez +6 more
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Bacillus subtilis CwlP of the SP-β Prophage Has Two Novel Peptidoglycan Hydrolase Domains, Muramidase and Cross-linkage Digesting dd-Endopeptidase [PDF]
, 2010 I Putu Sudiarta +2 more
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Journal of Internal Medicine, EarlyView.Abstract The etiology of Alzheimer's disease (AD) remains under active debate. In this perspective, we explore the hypothesis that a primarily infection‐caused chronic dysregulation and weakening of human innate immunity via the underexpression, degradation, and inactivation of innate immune proteins necessary for direct antimicrobial effects and ...
Annelise E. Barron +3 more
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Asparagine Endopeptidase (δ Secretase), an Enzyme Implicated in Alzheimer’s Disease Pathology, Is an Inhibitor of Axon Regeneration in Peripheral Nerves [PDF]
, 2020 Arthur W. English +4 more
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Controlling the Precision-Recall Tradeoff in Differential Dependency Network Analysis [PDF]
, 2013 Graphical models have gained a lot of attention recently as a tool for learning and representing dependencies among variables in multivariate data.
Clark, Vincent P. +4 more
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Journal of Periodontal Research, EarlyView.This graphical abstract illustrates the role of matrix metalloproteinases (MMPs) across the pathogenesis, diagnosis, and therapeutics of periodontal and peri‐implant diseases. Microbial and host stimuli trigger MMP activation leading to extracellular matrix breakdown, point‐of‐care aMMP‐8 detection aids diagnosis, and adjunctive or AI‐assisted ...
Timo Sorsa +5 more
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Inhibition of asparagine endopeptidase (AEP) effectively treats sporadic Alzheimer’s disease in mice [PDF]
, 2023 Zhengjiang Qian +7 more
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