Results 131 to 140 of about 34,911 (258)

Modulating the Gut‐Microbiota‐Brain Axis in Alzheimer's Disease: Therapeutic Potential of Nutritional and Metabolic Factors

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
This review systematically examines the role of gut microbiota modulation in Alzheimer's disease, focusing on how microbial metabolites and dietary nutrients influence cognitive function and AD pathology, as well as the neuroprotective effects through the gut‐brain axis.
Binyue Xu, Xuhuan Li, Shangling Dong, Zheyuan Zhang, Dong Jin, Guoping Li, Jiesheng Wang   +6 more
wiley   +1 more source

Cancer cell‐selective ectopic expression of CD20 as an antigen enables rituximab repurposing for solid tumour immunotherapy

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
A recombinant AAV delivered tumour gene therapy. NF‐κB drives tumour‐selective antigen (e.g., CD20) expression. Ectopic CD20 enables rituximab repurposing to solid tumours. ADCC, ADCP, and CDC contribute to the antitumour activity. Abstract Background Despite the clinical success of cancer immunotherapies, their efficacy is often compromised by antigen‐
Ziyan Kong, Yile Wang, Yunqi Zhao, Lu Wang, Zhimin Fan, Yongqian Shu, Jinke Wang   +6 more
wiley   +1 more source

Triple Threat: Elucidating Evolution Under Antibiotic, Metal, and Phage Pressure in Escherichia coli

Ecology and Evolution, Volume 16, Issue 9, September 2026.
Antibiotic resistance threatens treatment of bacterial infections, increasing research into alternative therapies, in particular whether new resistances will arise to these novel treatments. We evolved bacteria under phage, antibiotic, and heavy metal exposure.
Lindsey W. McGee, Noah K. Radtke, Gretchen S. Taylor, Joseph L. Graves Jr., Liesl Jeffers‐Francis   +4 more
wiley   +1 more source

Characterization of endopeptidases from the midgut of Morimus funereus (Coleoptera: Cerambycidae) larvae

, 2014
— Application of specific chromogenic substrates, use of class-specific inhibitors, and zymogram analysis enabled us to identify several peptidase classes in extracts of the midgut of Morimus funereus larvae. Zymogram analysis with gelatin as a peptidase
Nataša Božić, Vera Nenadović, Biljana Dojnov, Jelisaveta Ivanović, Ra Milovanović, Z. Vujčić   +5 more
core  

Bioactive Peptides From the Cucurbitaceae Family: From Identification and Health‐Promoting Functions to Industrial Utilization

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
From fruit to function: Cucurbitaceae‐derived peptide production, bioactive potential screening and industrial applications. ABSTRACT Cucurbitaceae is a major plant family within the kingdom Plantae, encompassing popular food crops such as zucchini, squash, pumpkins, and melons.
Himani R. Kekiri Obada Gamage, Mahya Bahmani, Utpal Bose, Mekhala Vithana, Michelle L. Colgrave, Angéla Juhász   +5 more
wiley   +1 more source

Fibroblast Activation Protein Expression Differs Between Inflamed and Fibrostenotic Inflammatory Bowel Disease

JCC Plus, Volume 1, Issue 5, September 2026.
This study demonstrates that fibroblast activation protein expression is elevated in inflamed and fibrostenotic inflammatory bowel disease, with highest levels in fibrostenotic Crohn's disease. Cellular fibroblast activation protein predominates in inflamed tissues and localises to α‐SMA−PDPN−CD90+ stromal cells. ABSTRACT Background Intestinal fibrosis
Dalia A. Lartey, Bram W. van Os, Bo Jun Ke, Kelly van Wijnbergen, Gert de Hertogh, Luuk J. A. C. Hawinkels, Gianluca Matteoli, Jie Su, Christianne J. Buskens, Jarmilla D. W. van der Bilt, Geert R. A. M. D'Haens, Joep Grootjans, Manon E. Wildenberg, Marieke C. Barnhoorn, Mark Löwenberg   +14 more
wiley   +1 more source

Antibacterial potential of five phages in controlling Enterococcus faecalis and Enterococcus faecium. [PDF]

Virol J
Tuomala H, Nylund T, Mustonen M, Flod A, Kiljunen S.   +4 more
europepmc   +1 more source

Amino acid residues modulating the activities of staphylococcal glutamyl endopeptidases. [PDF]

The glutamyl endopeptidase family of enzymes from staphylococci has been shown to be important virulence determinants of pathogenic family members, such as Staphylococcus aureus. Previous studies have identified the N-terminus and residues from positions
Baba, Tomomi T, Nemoto, Takayuki K, Ohara-Nemoto, Yuko, Kobayakawa, Takeshi, Ono, Toshio, Kimura, Shigenobu, Shimoyama, Yu, Okawara, Hisami   +7 more
core  

New plant endopeptidases with potential application in cheesemaking

Results are given on the milk clotting properties and casein hydrolytic behaviour of partially purified extracts of four new cysteine plant endopeptidases: balansain, hieronymain, asclepain f, and philibertain g.
Caffini, N., Pardo, M., Bruno, M., Sequeiros, C., Natalucci, C., Trejo, S., López, L.   +6 more
core   +1 more source

Plasma Proteomic Profiling Identifies Candidate Biomarkers for Pancreatic Ductal Adenocarcinoma

Journal of Clinical Laboratory Analysis, Volume 40, Issue 17, September 2026.
Using DIA‐based plasma proteomics followed by ELISA validation, we identified eight circulating proteins that were significantly elevated in patients with pancreatic ductal adenocarcinoma. These proteins reflect key tumor‐associated biological processes, including exocrine dysfunction and immune remodeling, and may serve as candidates for future multi ...
Lelang Xiang, Yi Jin, Ran Hu, Yuhang He, Yong Zhang, Ang Li   +5 more
wiley   +1 more source