Results 101 to 110 of about 194,866 (319)
Naturally Occurring Genetic Variation Influences the Severity of Drosophila Eye Degeneration Induced by Expression of a Mutant Human Insulin Gene [PDF]
arXiv, 2013 Dominant negative mutations in the insulin gene are the second most common cause of permanent neonatal diabetes. However, variation in severity and penetrance of neonatal diabetes, as in other complex genetic diseases, cannot be accounted for by known disease mutations.
arxiv
Current molecular medicine, 2016 Hypoxia is a major hallmark of the tumor microenvironment that is strictly associated with rapid cancer progression and induction of metastasis. Hypoxia inhibits disulfide bond formation and impairs protein folding in the Endoplasmic Reticulum (ER).
W. Rozpędek +5 more
semanticscholar +1 more source
Recent Advances in Highly Luminescent Carbon Dots
Advanced Functional Materials, EarlyView.Here, a comprehensive summary of the advancements is provided in highly luminescent carbon dots across various luminescence bands since their discovery in 2004. It systematically covers the synthesis, structural characteristics, preparation strategies, and essential purification of these carbon dots, along with their applications in efficient ...
Yupeng Liu +6 more
wiley +1 more source
Location matters: the endoplasmic reticulum and protein trafficking in dendrites
Biological Research, 2011 Neurons are highly polarized, but the trafficking mechanisms that operate in these cells and the topological organization of their secretory organelles are still poorly understood.
Omar A Ramírez +2 more
doaj
Pharmacological targeting of endoplasmic reticulum stress in disease
Nature reviews. Drug discovery, 2021 S. Marciniak, Joseph E. Chambers, D. Ron
semanticscholar +1 more source
Engineering the Future of Restorative Clinical Peripheral Nerve Surgery
Advanced Healthcare Materials, EarlyView.What if damaged nerves could regenerate more effectively? This review unveils cutting‐edge strategies to restore nerve function, from biomaterial scaffolds and bioactive molecules to living engineered tissues. By accelerating axonal regrowth, preserving Schwann cells, and enhancing connectivity, these approaches are reshaping nerve repair—offering new ...
Justin C. Burrell +5 more
wiley +1 more source
Cellular Physiology and Biochemistry, 2016 Background/Aims: Melatonin, which is mainly secreted by the pineal gland and released into blood, has anti-inflammatory properties in acute pancreatitis. Many studies show that melatonin can relieve inflammation in taurocholate-induced acute pancreatitis.
Yina Chen +6 more
doaj +1 more source
Endoplasmic reticulum phosphate transport
Kidney International, 1996 The major role of the liver endoplasmic reticulum phosphate/pyrophosphate transport proteins is the regulation of blood glucose levels. The glucose-6-phosphatase enzyme is an endoplasmic reticulum enzyme system which hydrolyzes glucose-6-phosphate to glucose and phosphate.
openaire +3 more sources
Advanced Healthcare Materials, EarlyView.This study develops itaconate‐based polymer microparticles (IA‐MPs) for macrophage‐targeted intracellular delivery, overcoming the limitations of traditional itaconate administration. IA‐MPs achieve controlled release through phagocytosis, reducing pro‐inflammatory cytokine expression and reprogramming macrophage metabolism toward glycolysis.
Kaitlyn E. Woodworth +10 more
wiley +1 more source
Journal of Lipid Research, 1998 The transport of newly synthesized cholesterol from its site of synthesis, the endoplasmic reticulum, to the plasma membrane was studied in CaCo-2 cells. The appearance of newly synthesized cholesterol on the cell surface was rapid. By 30 min, 50% of the
F. Jeffrey Field +3 more
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