Preferential Membrane Remodeling on Curved Biointerfaces Induced by Conjugated Oligoelectrolyte
Advanced Materials Interfaces, EarlyView.This study explores how membrane shape influences the interaction of conjugated oligoelectrolytes (COEs) with lipid bilayers. Using a curved biointerface composed of nanobar arrays and supported lipid bilayers, it is revealed that COE intercalation preferentially remodels curved regions, forming distinct structures. These findings highlight the role of
Xinwen Miao +7 more
wiley +1 more source
MAM-mediated mitophagy and endoplasmic reticulum stress: the hidden regulators of ischemic stroke
Frontiers in Cellular NeuroscienceIschemic stroke (IS) is the predominant subtype of stroke and a leading contributor to global mortality. The mitochondrial-associated endoplasmic reticulum membrane (MAM) is a specialized region that facilitates communication between the endoplasmic ...
Ziyi Jia +8 more
doaj +1 more source
Observation of Multiphoton-induced Fluorescence from Nano Graphene Oxide and Its Applications in In vitro and In vivo Bioimaging [PDF]
arXiv, 2012 In the present paper, we observed both two-photon and three-photon induced distinct photoluminescence from GO nanoparticles under fs laser excitation. Conjugated with PEG molecules, GO nanoparticles exhibited high chemical stability, and could effectively label HeLa cells.
arxiv
A guide to understanding endoplasmic reticulum stress in metabolic disorders
Molecular Metabolism, 2021 Imke L. Lemmer +3 more
semanticscholar +1 more source
Inhalable Hsa‐miR‐30a‐3p Liposomes Attenuate Pulmonary Fibrosis
Advanced Science, EarlyView.The study explores inhalable hsa‐miR‐30a‐3p‐loaded liposomes as a treatment for bleomycin‐induced pulmonary fibrosis in mice. Hsa‐miR‐30a‐3p is electroporated into liposomes and formulated into a dry powder for inhalation. Delivered via dry powder inhalation, it improves pulmonary function, promotes myofibroblast de‐differentiation by targeting CNPY2 ...
Shuo Liu +14 more
wiley +1 more source
Functional Polarization of Liver Macrophages by Glyco Gold Nanoparticles
Advanced Science, EarlyView.Macrophages play a critical role in several pathophysiological diseases by being involved in the activation of adaptive and innate immune responses. The repolarization of macrophages using gold nanoparticles functionalized with glycans for a more selective targeting toward a restorative phenotype leads to an amelioration of the events.
Jennifer Fernandez Alarcon +25 more
wiley +1 more source
Penfluridol induces endoplasmic reticulum stress leading to autophagy in pancreatic cancer
Tumor Biology, 2017 Pancreatic cancer is one of the most aggressive and difficult to treat cancers. Experimental and clinical evidence suggests that high basal state autophagy in pancreatic tumors could induce resistance to chemotherapy.
Alok Ranjan +4 more
doaj +1 more source
ENZYME-STRUCTURE RELATIONSHIPS IN THE ENDOPLASMIC RETICULUM OF RAT LIVER [PDF]
, 1962 Lars Ernster +2 more
openalex +1 more source
Contacts between the endoplasmic reticulum and other membranes in neurons
Proceedings of the National Academy of Sciences of the United States of America, 2017 Significance The cytoplasm of eukaryotic cells is compartmentalized by intracellular membranes that define subcellular organelles. One of these organelles, the endoplasmic reticulum, forms a continuous network of tubules and cisternae that extends ...
Matthias Haberl, Mark Ellisman
semanticscholar +1 more source
Advanced Science, EarlyView.Traditional Chinese Medicine (TCM), while holistic and historically esteemed, faces challenges in “miracle cures” due to slow onset, long cycles, and difficulty controlling quality. This study obtains the active ingredients, glabridin (GLA) and puerarin (PUE), from Ge‐Gen Decoction (GGD), developing a safe and effective drug delivery system, GLA‐PUE ...
Jianhong Qi +7 more
wiley +1 more source