Results 131 to 140 of about 194,866 (319)
Phases, morphologies, and transitions in a membrane model for the endoplasmic reticulum [PDF]
arXivWe introduce a novel model, comprising self-avoiding surfaces and incorporating edges and tubules, that is designed to characterize the structural morphologies and transitions observed within the endoplasmic reticulum (ER). By employing discretized models, we model smooth membranes with triangulated surfaces, and we utilize numerical variational ...
arxiv
The role of endoplasmic reticulum stress in human pathology.
Annual Review of Pathology, 2015 Numerous genetic and environmental insults impede the ability of cells to properly fold and posttranslationally modify secretory and transmembrane proteins in the endoplasmic reticulum (ER), leading to a buildup of misfolded proteins in this organelle--a
Scott A Oakes, F. Papa
semanticscholar +1 more source
Advanced Science, EarlyView.A GRP78 nanobody‐directed immunotoxin suppresses cancer progression and metastasis by enhancing antitumor immunity via STING pathway activation, offering a pan‐cancer‐targeted approach and immunotherapy combination strategy. Abstract The lack of targetable antigens poses a significant challenge in developing effective cancer‐targeted therapies.
Huifang Wang +16 more
wiley +1 more source
Cell Reports, 2019 Summary: Calcium homeostasis in the lumen of the endoplasmic reticulum is required for correct processing and trafficking of transmembrane proteins, and defects in protein trafficking can impinge on cell signaling pathways. We show here that mutations in
Annabelle Suisse, Jessica E. Treisman
doaj
ON THE RELATIONSHIP OF LIVER GLUCOSE-6-PHOSPHATASE TO THE PROLIFERATION OF ENDOPLASMIC RETICULUM IN PHENOBARBITAL INDUCTION [PDF]
, 1966 Sten Orrenius, Jan L. E. Ericsson
openalex +1 more source
Endoplasmic Reticulum Stress in Metabolic Disorders
Cells, 2018 Metabolic disorders have become among the most serious threats to human health, leading to severe chronic diseases such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease, as well as cardiovascular diseases.
Rose Ghemrawi +2 more
semanticscholar +1 more source
Advanced Science, EarlyView.RNF112, an E3 ubiquitin ligase, is markedly reduced in bladder cancer (BLCA). It curbs BLCA cell proliferation, migration, and lipid production primarily by enhancing ubiquitin‐dependent degradation of c‐Myc. This degradation inhibits c‐Myc's role in upregulating ACLY, a crucial enzyme for lipid synthesis, highlighting RNF112's potential as a ...
Kangping Xiong +13 more
wiley +1 more source
Active unidirectional network flow generates a packet molecular transport in cells [PDF]
arXiv, 2018 Internet, social media, neuronal or blood vessel are organized in complex networks. These networks are characterized by several quantities such as the underlying graph connectivity (topology), how they grow in time, scaling laws or by the mean time a random search can cover a network and also by shortest path between two nodes.
arxiv
PHYSICOCHEMICAL DIFFERENCES BETWEEN FRAGMENTS OF PLASMA MEMBRANE AND ENDOPLASMIC RETICULUM [PDF]
, 1966 Donald F. Hoelzl Wallach +2 more
openalex +1 more source
Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies
Advanced Science, EarlyView.Metastasis is the leading cause of death in patients with lung cancer. Nanomedicine can be used to prepare efficient drug delivery systems owing to their advantages and plays an important role in the synergistic antimetastasis of lung cancer. This comprehensive review summarizes the emerging nanostrategies against lung cancer metastasis based on the ...
Fan Xu +7 more
wiley +1 more source