Results 131 to 140 of about 278,078 (149)

Fluorescence Lifetime Multiplexing with Environment‐Sensitive Chemigenetic Probes

ChemBioChem, EarlyView.
The fluorescence lifetimes of coumarin‐pyridinium dyes are sensitive to the environment, with lifetimes decreasing as the polarity of the solvent increases. Herein, it is shown that this trend is preserved in the binding pockets of proteins, enabling multiplexed imaging of three targets in live cells with a single fluorophore, and informing the design ...
Sarah Emmert, Anna Rovira, Pablo Rivera‐Fuentes   +2 more
wiley   +1 more source

CHOP aggravates hepatocyte apoptosis upon endoplasmic reticulum stress by downregulating autophagy. [PDF]

Cell Stress Chaperones
Wu JY, Han B, Yang T, Zheng L, Guo YX, Li JY, Guo XY, Yin HH, Xie RJ.   +8 more
europepmc   +1 more source

Development and Recent Advances in SLIPT‐PM: A Chemogenetic Platform for Manipulating Signaling at the Plasma Membrane

ChemBioChem, Accepted Article.
Upon cell stimulation, mammalian cells activate various signaling proteins and lipids by recruiting their upstream regulators to the inner leaflet of the plasma membrane (PM), which in turn determines their cellular response. Therefore, artificially inducing protein translocation to the PM is an effective strategy for dissecting cell signaling networks
Shuya Ohira, Akinobu Nakamura, Kenta Terai, Shinya Tsukiji   +3 more
wiley   +1 more source

The contribution of the Golgi and the endoplasmic reticulum to calcium and pH homeostasis in Toxoplasma gondii. [PDF]

J Biol Chem
Calixto A, Moen KE, Moreno SNJ.
europepmc   +1 more source

Unveiling New Triazoloquinoxaline‐Based PROTACs Designed for the Selective Degradation of the ncBAF Chromatin Remodeling Subunit BRD9

Chemistry – A European Journal, EarlyView.
We present new BRD9‐targeting degraders featuring a chemical warhead and E3 ligase ligand that distinctly differ from the typical chemical units used for BRD9 degradation. Specifically, we identified two VHL‐based PROTACs (2 and 9) based on a [1,2,4]triazolo[4,3‐a]quinoxaline scaffold that effectively and selectively degrade BRD9 and exhibit ...
Martina Pierri, Guglielmo Bove, Erica Gazzillo, Ester Colarusso, Francesca Scala, Giacomo Pepe, Stefania Terracciano, Maria Giovanna Chini, Nicla Simonelli, Ines Bruno, Angela Nebbioso, Pietro Campiglia, Giuseppe Bifulco, Lucia Altucci, Nunzio Del Gaudio, Gianluigi Lauro   +15 more
wiley   +1 more source

SIGMAR1 screened by a GPCR-related classifier regulates endoplasmic reticulum stress in bladder cancer. [PDF]

J Transl Med
Zhuang J, Wang Y, Wu X, Peng Z, Huang Z, Zhao C, Shen B.   +6 more
europepmc   +1 more source

Improved C5‐Amide Bioisosteres for Human Neuraminidase 1 Inhibitors Based on 2‐Deoxy‐2,3‐Didehydro‐N‐Acetyl Neuraminic Acid

ChemMedChem, EarlyView.
This article describes the development of improved NEU1 inhibitors based on the 2‐deoxy‐2,3‐didehydro‐N‐acetyl neuraminic acid scaffold. A series of candidate inhibitors are designed containing bioisosteres of the C5‐amide group and evaluated for activity against NEU1‐4 enzymes.
Mostafa Radwan, Elisa G. Carvajal, Christopher W. Cairo   +2 more
wiley   +1 more source

The endoplasmic reticulum as an active liquid network. [PDF]

Proc Natl Acad Sci U S A
Scott ZC, Steen SB, Huber G, Westrate LM, Koslover EF.   +4 more
europepmc   +1 more source

Changes in Protein Expression of Renal Drug Transporters and Drug‐Metabolizing Enzymes in Autosomal Dominant Polycystic Kidney Disease Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Autosomal dominant polycystic kidney disease is the most prevalent inherited kidney disease and leads to bilateral kidney enlargement and progressive loss of renal function, often over decades. Comorbidities include hypertension, flank pain, and bacterial infections. The condition often necessitates prolonged multidrug therapy.
Annika C. Tillmann, Dorien J. M. Peters, Amin Rostami‐Hodjegan, Patricia Wilson, Jill Norman, Jill Barber, Zubida M. Al‐Majdoub   +6 more
wiley   +1 more source

Calreticulin-From the Endoplasmic Reticulum to the Plasma Membrane-Adventures of a Wandering Protein. [PDF]

Cancers (Basel)
Okura GC, Bharadwaj AG, Waisman DM.
europepmc   +1 more source