Results 181 to 190 of about 194,866 (319)

Efficient and Specific PDGFRβ‐Targeting Dual‐Mode T1‐T2 MRI Nanoprobe for Early Diagnosis of Non‐Alcoholic Fatty Liver

open access: yesAdvanced Science, EarlyView.
The Fe3O4/Gd@BSA‐pPB nanoprobe leverages biomimetic mineralization and targets hepatic stellate cells (HSCs) through PDGFRβ, offering superior enrichment in fibrotic regions. This targeted delivery overcomes biological barriers, enhancing both the accuracy and sensitivity of MRI imaging at early disease stages.
Zehua Li   +11 more
wiley   +1 more source

A CLDN18.2‐Targeted Nanoplatform Manipulates Magnetic Hyperthermia Spatiotemporally for Synergistic Immunotherapy in Gastric Cancer

open access: yesAdvanced Science, EarlyView.
CLDN18.2 is a highly selective biomarker exposed in gastric cancer. A CLDN18.2‐specific antibody 1D5 conjugated fluorescence‐magnetic nanoparticle is developed for image‐guided precision theragnostics. Under the assistance of sensitive FMI and deep‐penetrating MPI for tracing and timing the optimal nanoparticle dosage, combining α‐PD1 therapy with ...
Xueying Wang   +14 more
wiley   +1 more source

Dynamic Covalent Michael Acceptors to Penetrate Cells: Thiol‐Mediated Uptake with Tetrel‐Centered Exchange Cascades, Assisted by Halogen‐Bonding Switches

open access: yesAngewandte Chemie, Volume 134, Issue 51, December 19, 2022., 2022
Introduced as the first explicitly tetrel‐centered cascade exchangers, Michael acceptors are shown to enable and inhibit thiol‐mediated uptake, generate distinct patterns in heatmaps to decode uptake circuitry, integrate novel halogen‐bonding switches, deliver proteins to the cytosol, and break, as dimers, records for uptake inhibition related to drug ...
Inga Shybeka   +5 more
wiley   +2 more sources

LIPUS Promotes Calcium Oscillation and Enhances Calcium Dependent Autophagy of Chondrocytes to Alleviate Osteoarthritis

open access: yesAdvanced Science, EarlyView.
A non‐invasive and safe physical therapy, low‐intensity pulsed ultrasound (LIPUS) can alleviate osteoarthritis. This study dynamically “visualizes” the invisible mechanical stimuli of LIPUS on living chondrocytes by fluorescence imaging technology in the form of calcium oscillations, confirming LIPUS maintains cartilage homeostasis by promoting ...
Mengtong Guan   +12 more
wiley   +1 more source

DAPK3 is Essential for DBP‐Induced Autophagy of Mouse Leydig Cells

open access: yesAdvanced Science, EarlyView.
This study has confirmed that death‐associated protein kinase 3 (DAPK3) is essential for dibutyl phthalate (DBP)‐induced autophagy of mouse Leydig cells, and is regulated by both transcription factor specific protein 2 (Sp2) and parkin RBR E3 ubiquitin‐protein ligase (PRKN), and melatonin can alleviate DBP‐induced autophagy of the cells.
Si Yang   +4 more
wiley   +1 more source

Tumor‐Adhesive Chitosan‐Derived Multi‐Immune Agonist Unleashes Strong and Durable Anti‐Cancer Immunity

open access: yesAdvanced Science, EarlyView.
A tumor‐adhesive chitosan‐derived immune agonist TACTIC is developed for strong and durable anti‐tumor immunity. The immune agonist exhibits multi‐targets and modulates both tumor cell immunogenicity and pro‐inflammatory responses in immune cells, thereby potentiating the therapeutic efficacy of clinical radiotherapy.
Huilan He   +8 more
wiley   +1 more source

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